Acquired bilateral melanosis of the neck in perimenopausal women

Park, J.-Y.; Kim, Y.C.; Lee, Eun‐So; Park, K.-C.; Kang, Hyun-Woo

doi:10.1111/j.1365-2133.2011.10735.x

Cited by 16 publications

(21 citation statements)

References 13 publications

(14 reference statements)

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“…The vacuolar change of basal layer without spongiosis accompanying dermal melanin deposition, implies the possibility of similar underlying pathomechanism as seen in pigmented contact dermatitis (PCD), also known as Riehl’s melanosis (14). PCD is a rare variant of non-eczematous contact dermatitis, which is believed to be caused by repetitive contacts with very small amounts of allergens, such as washing powder, fragrance or cosmetics (1516).…”

Section: Discussionmentioning

confidence: 99%

Acquired Bilateral Dyspigmentation on Face and Neck: Clinically Appropriate Approaches

et al. 2016

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Facial dyspigmentation in Asian women often poses diagnostic and therapeutic challenges. Recently, a distinctive bilateral hyperpigmentation of face and neck has occasionally been observed. This study was performed to investigate the clinico-pathological features of this dyspigmentation as well as proper treatment approaches. We retrospectively investigated the medical records including photographs, routine laboratory tests, histopathologic studies of both lesional and peri-lesional normal skin and patch test of thirty-one patients presented acquired bizarre hyperpigmentation on face and neck. The mean age of patients was 52.3 years and the mean duration of dyspigmentation was 24.2 months. In histologic evaluations of lesional skin, a significantly increased liquefactive degeneration of basal layer, pigmentary incontinence and lymphocytic infiltration were noted, whereas epidermal melanin or solar elastosis showed no statistical differences. Among 19 patients managed with a step-by-step approach, seven improved with using only topical anti-inflammatory agents and moisturizer, and 12 patients gained clinical benefit after laser therapy without clinical aggravation. Both clinical and histopathologic findings of the cases suggest a distinctive acquired hyperpigmentary disorder related with subclinical inflammation. Proper step-by-step evaluation and management of underlying subclinical inflammation would provide clinical benefit.

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Section: Discussionmentioning

confidence: 99%

Acquired Bilateral Dyspigmentation on Face and Neck: Clinically Appropriate Approaches

et al. 2016

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“…In a study of 14 Korean women with acquired bilateral melanosis of the neck consistent with Riehl's melanosis, Park et al . have noted that although some cases showed positive photopatch tests, they were of doubtful relevance . Various treatments, individually as well as in combinations, have been attempted with variable success in Riehl's melanosis …”

Section: Riehl's Melanosismentioning

confidence: 99%

A global consensus statement on ashy dermatosis, erythema dyschromicum perstans, lichen planus pigmentosus, idiopathic eruptive macular pigmentation, and Riehl's melanosis

et al. 2018

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Ashy dermatosis (AD), lichen planus pigmentosus (LPP), erythema dyschromicum perstans (EDP), and idiopathic eruptive macular pigmentation are several acquired macular hyperpigmentation disorders of uncertain etiology described in literature. Most of the published studies on these disorders are not exactly comparable, as there are no clear definitions and different regions in the world describe similar conditions under different names. A consensus on the terminology of various morphologies of acquired macular pigmentation of uncertain etiology was a long-felt need. Several meetings of pigmentary disorders experts were held to address this problem. A consensus was reached after several meetings and collation of e-mailed questionnaire responses and e-mail communications among the authors of publications on the above conditions. This was achieved by a global consensus forum on AD, LPP, and EDP, established after the 22nd International Pigment Cell Conference held in Singapore in 2014. Thirty-nine experts representing 18 countries participated in the deliberations. The main focus of the deliberations was terminology of the conditions; as such, we present here the consensus statement of the forum and briefly review the available literature on the subject. We have not attempted to discuss treatment modalities in detail.

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“…Natural killer group 2D positive (NKG2D+) cells such as NK, NKT, and CD8+ T cells and NKG2D activating ligands from the MHC I-related chain A family also have a key role in pathogenesis 2 . CD4+/ CD25+ T-cells are also involved 3,4 . Most therapies of AA target the autoimmune reaction, but a new therapy modality is being needed because of limitations and complications of previous therapies 5 .…”

Section: Conflicts Of Interestmentioning

confidence: 99%

“…On the other hand, follicular keratotic plugs and perifollicular halo were observed only in one and 3 of 9 patients, respectively, at a lower rate than in the face. The major histopathologic features of Riehl's melanosis are vacuolar degeneration of the basal layer and pigment incontinence of the dermis 4 . These pathological features correspond with grey dots/granules on the dermoscopic images that represent melanophages in the dermis 5 .…”

mentioning

confidence: 99%

Differences among Dermoscopic Findings in Riehl's Melanosis of the Cheek and Neck

et al. 2019

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Acquired bilateral melanosis of the neck in perimenopausal women

Cited by 16 publications

References 13 publications

Acquired Bilateral Dyspigmentation on Face and Neck: Clinically Appropriate Approaches

Acquired Bilateral Dyspigmentation on Face and Neck: Clinically Appropriate Approaches

A global consensus statement on ashy dermatosis, erythema dyschromicum perstans, lichen planus pigmentosus, idiopathic eruptive macular pigmentation, and Riehl's melanosis

Differences among Dermoscopic Findings in Riehl's Melanosis of the Cheek and Neck

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