Acquired Bartter syndrome following gentamicin therapy

Singh, Jagjeet; Patel, Munna Lal; Gupta, Kavya; Pandey, Sushil; Dinkar, Anju

doi:10.4103/0971-4065.177206

Cited by 10 publications

(5 citation statements)

References 7 publications

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“…In fact, complete inhibition of transport in the TAL can cause a Bartter‐like syndrome, which, besides hypomagnesemia, is a constellation of renal sodium loss, hypokalemia, hypocalcemia, and low‐normal blood pressure. 34 , 35 …”

Section: Drugs Associated With Hypomagnesemiamentioning

confidence: 99%

“…Stimulation of this receptor inhibits tubular transport by this segment as well as the paracellular transport of Mg. In fact, complete inhibition of transport in the TAL can cause a Bartter‐like syndrome, which, besides hypomagnesemia, is a constellation of renal sodium loss, hypokalemia, hypocalcemia, and low‐normal blood pressure 34,35 …”

Section: Drugs Associated With Hypomagnesemiamentioning

confidence: 99%

“…In fact, complete inhibition of transport in the TAL can cause a Bartter-like syndrome, which, besides hypomagnesemia, is a constellation of renal sodium loss, hypokalemia, hypocalcemia, and low-normal blood pressure. 34,35 The renal toxicity of amphotericin B usually occurs more distally in the kidney, namely in the DCT. Although the general characteristics of amphotericin B nephrotoxicity are known (increased tubular permeability, necrosis, arterial vasoconstriction), it remains unclear how this drug can specifically perturb renal Mg transport in this nephron segment.…”

Section: Antibioticsmentioning

confidence: 99%

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An overview of diagnosis and management of drug‐induced hypomagnesemia

Liamis

Hoorn

Florentin

et al. 2021

Pharmacology Res & Perspec

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Hypomagnesemia is usually defined as a serum magnesium (Mg) level below 0.65 mmol/L (1.3 mEq/L; 1.5 mg/dl). 1 Serum Mg exists in three forms: (1) free or ionized Mg, the physiologically active form that accounts for 55%-70% of total serum Mg; (2) Mg complexed to anions, including bicarbonates, sulfates, phosphates, and citrates (5%-15%) and (3) Mg bound to serum proteins (primarily albumin), constituting the remaining approximately 30%. 2 Similarly to hypocalcemia, hypoalbuminemia is also related to spurious hypomagnesemia. 3 Consequently, in hypoalbuminemic states (serum albumin <4 g/dl) corrected serum Mg should be calculated using the formula: corrected Mg (mmol/L) = measured Mg(mmol/L) + 0.005 × (40 − albumin g/L). 4 Correction of Mg for albumin levels is rarely performed in clinical practice, a strategy that should probably change.The incidence of hypomagnesemia varies considerably from merely 2% among individuals in the community up to as high as 65% in patients hospitalized in intensive care units. 5,6 Discrepancies in the reported incidences of hypomagnesemia are attributed to the fact that serum Mg is not routinely measured and that this ion is

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Section: Drugs Associated With Hypomagnesemiamentioning

confidence: 99%

Section: Drugs Associated With Hypomagnesemiamentioning

confidence: 99%

Section: Antibioticsmentioning

confidence: 99%

See 1 more Smart Citation

An overview of diagnosis and management of drug‐induced hypomagnesemia

Liamis

Hoorn

Florentin

et al. 2021

Pharmacology Res & Perspec

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“…The literature search process is summarized in Figure 1 . For the final analysis, we evaluated 46 reports [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ] published between 1961 and 2020 in English (N = 45) and Spanish (N = 1). They had been reported from the following countries: United States of America (N = 12), India (N = 8), United Kingdom (N = 7), Turkey (N = 4), Ireland (N = 3), Greece, Israel, Taiwan (N = 2), Australia, Belgium, Canada, Croatia, Paraguay, and Spain (N = 1).…”

Section: Resultsmentioning

confidence: 99%

Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review

et al. 2021

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Aminoglycoside or colistin therapy may alter the renal tubular function without decreasing the glomerular filtration rate. This association has never been extensively investigated. We conducted a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. Databases searched included United States National Library of Medicine, Excerpta Medica, and Web of Science. For the final analysis, we evaluated 46 reports, published after 1960, describing 82 cases. A total of 286 electrolyte and acid-base disorders were reported. Hypomagnesemia, hypokalemia, and hypocalcemia were reported in more than three quarter of cases. Further disorders were, in decreasing order of frequency, metabolic alkalosis, hyponatremia, hypophosphatemia, hypouricemia, hypernatremia, and metabolic acidosis. Six electrolyte and acid-base disorders were reported in seven cases, five in 12 cases, four in 16 cases, three in 31 cases, two in 11 cases, and one in five cases. Laboratory features consistent with a loop of Henle/distal tubular dysfunction were noted in 56 (68%), with a proximal tubular dysfunction in three (3.7%), and with a mixed dysfunction in five (6.1%) cases. The laboratory abnormality was unclassified in the remaining 18 (22%) cases. Treatment with aminoglycosides or colistin may trigger a proximal tubular or, more frequently, a loop of Henle/distal tubular dysfunction.

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“…В механизмах развития гипомагниемии при назначении аминогликозидов отмечают стимулирование чувствительных к кальцию рецепторов, расположенных на базолатеральной мембране эпителиоцитов проксимальных канальцев и восходящем колене петли Генле. Вследствие стимуляции рецепторов в этих сегментах ингибируется канальцевый транспорт и параклеточный транспорт магния, снижается реабсорбция ионов магния (а также калия, кальция, натрия и хлора), повышается транспорт в дистальные канальцы и усиливается экскреция электролитов [33]. Гипомагниемию нередко отмечают и после прекращения терапии аминогликозидами.…”

Section: тиазидные диуретикиunclassified

Гомеостаз Магния И Лекарственно-Индуцированная Гипомагниемия

Трисветова¹

2022

Кардиология В Беларуси

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Магний относится к жизненно важным макроэлементам, участвующим во многих биологических и физиологических процессах в организме человека. Поскольку магний является внутриклеточным элементом - 99% общего магния находится в клетках, в большинстве случаев при исследовании сыворотки крови дефицит магния не диагностируют. Предположения о наличии недостатка магния в организме должны возникать на основании знаний о соматических заболеваниях, сопровождающихся снижением абсорбции или повышением экскреции элемента, с учетом возраста, пола, некоторых физиологических состояний (беременность, лактация), особенностях физической активности и диетического режима пациента. Дефицит магния проявляется многими клиническими симптомами, маскирующимися признаками известных соматических заболеваний человека, усугубляя их течение. Причинами дефицита магния являются стрессовые состояния и значительные физические нагрузки, беременность и лактация у женщин, хронические и острые заболевания внутренних органов, снижение содержания иона в воде и пище в связи с преобладанием в рационе современного человека рафинированных переработанных продуктов питания с низким содержанием магния. Применение более 50 препаратов сопровождается снижением уровня магния в организме. Для предотвращения дефицита магния необходимо определять его уровень в тканях и восполнять концентрацию иона препаратами магния. Оротовая соль магния - Магнерот - относится к эффективным и безопасным средствам для профилактики и лечения дефицита магния. Magnesium is one of the vital macronutrients involved in many biological and physiological processes in the human body. Since magnesium is an intracellular element - 99% of total magnesium is in cells, in most cases, when examining blood serum, magnesium deficiency is not diagnosed. Assumptions about the presence of a lack of magnesium in the body should arise on the basis of knowledge about somatic diseases, accompanied by a decrease in absorption or an increase in excretion of the element, taking into account age, sex, some physiological conditions (pregnancy, lactation), the characteristics of physical activity and the patient’s diet. Magnesium deficiency is manifested by many clinical symptoms, masking manifestations of known human somatic diseases, aggravating their course. The reasons for magnesium deficiency are stressful conditions and significant physical activity, pregnancy and lactation in women, chronic and acute diseases of internal organs, a decrease in the ion content in water and food due to the prevalence of refined processed foods with a low magnesium content in the diet of a modern person. The use of more than 50 drugs is accompanied by a decrease in the level of magnesium in the body. To prevent magnesium deficiency, it is necessary to control its level in tissues and replenish the concentration of the ion with magnesium preparations. Orotovaya magnesium salt - Magnerot, refers to an effective means for the prevention and treatment of magnesium deficiency.

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Acquired Bartter syndrome following gentamicin therapy

Cited by 10 publications

References 7 publications

An overview of diagnosis and management of drug‐induced hypomagnesemia

An overview of diagnosis and management of drug‐induced hypomagnesemia

Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review

Гомеостаз Магния И Лекарственно-Индуцированная Гипомагниемия

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