Acquired Antibiotic Resistance in Escherichia coli Exposed to Simulated Microgravity: Possible Role of Other Space Stressors and Adaptive Responses

Mortazavi, S.M.J.

doi:10.1128/mbio.00165-19

Cited by 7 publications

(9 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We thank Dr. Mortazavi for pointing out the role of radiation as an important factor under microgravity conditions (1) while referring to our paper (2). We agree with Dr. Mortazavi that radiation is an important component when it comes to assessment of bacterial response to the space environment.…”

Section: Replymentioning

confidence: 99%

Reply to Mortazavi, “Acquired Antibiotic Resistance in Escherichia coli Exposed to Simulated Microgravity: Possible Role of Other Space Stressors and Adaptive Responses”

Tirumalai

Fox

2019

mBio

View full text Add to dashboard Cite

Section: Replymentioning

confidence: 99%

Reply to Mortazavi, “Acquired Antibiotic Resistance in Escherichia coli Exposed to Simulated Microgravity: Possible Role of Other Space Stressors and Adaptive Responses”

Tirumalai

Fox

2019

mBio

View full text Add to dashboard Cite

“…Some microorganisms have demonstrated persistent resident populations in microgravity, surviving successive space flights ( Aunins Thomas et al, 2018 ; Singh et al, 2018 ; More et al, 2019 ; Mortazavi, 2019 ). These include those indicated as a biosafety level 2 microorganism: Acinetobacter baumannii , Haemophilus influenzae , Klebsiella pneumoniae , Salmonella enterica , Shigella sonnei , Staphylococcus aureus , Yersinia frederiksenii , and Aspergillus lentulus ( Aunins Thomas et al, 2018 ).…”

Section: Microbiological and Viral Behaviour And Pharmacological Resi...mentioning

confidence: 99%

Skin microbiome considerations for long haul space flights

Caswell¹,

Eshelby²

2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Dysbiosis of the human skin microbiome has long been associated with changes to the pH of the skin, dermal immune function and chronic skin conditions. Dermatological issues have been noted as the most prevalent medical presentation in the microgravity environment of space. The change in gravitational forces has been implicated in human immuno-suppression, also impacted by changes in the gastrointestinal-skin axis and its impact on Vitamin D metabolism, altered microbial gene expression in resident flora (leading changes in biofilm formation) and increased virulence factors in potential pathogens. There are also other stressors to the skin microbiome unique to space travel, including increased exposure to radiation, prolonged periods of dry washing technique, air quality and changes in microbe replication and growth parameters. Optimal microbiome health leads to enhanced skin barrier manufacture and maintenance, along with improved skin immune function and healing. In a microgravity environment expected to be experienced during long space flights, disruptions to the skin microbiome, coupled with increased virulence of pathological viruses and bacteria has implications for holistic skin health, astronaut cognitive function and mental health, and is coupled with slowed rates of wound healing. Scenario management for holistic skin health and restoration of microbiome homeostasis on long space flights require consideration.

show abstract

“…Furthermore, microgravity is just one factor during spaceflight that has been shown to increase antibiotic resistance [ 54 ]. The bacterial adaptive response, which is the exposure to a sub-lethal stressor which induces resistance to a lethal level of the same or different stressor [ 55 ], can also be triggered by ionising [ 56 ] and non-ionising radiation [ 57 ] found as part of the cosmic radiation [ 54 ]. Radiation may cause changes to antibiotic efflux pumps and sensitivity to chemicals [ 56 ].…”

Section: Prokaryotic Responses To Microgravitymentioning

confidence: 99%

“…Microgravity has a severe impact on the immune system both as a whole and on its individual components and will be discussed in the following sections. Additionally, microgravity and other space stressors such as radiation, sleep deprivation, isolation and microbial contamination have been shown to suppress immune function [ 54 ]. This review will summarise how the natural defence against pathogens is affected and how the crosstalk between immune cells and bacterial pathogens is also altered by the microgravity stressor.…”

Section: Prokaryotic Responses To Microgravitymentioning

confidence: 99%

Immunity in Space: Prokaryote Adaptations and Immune Response in Microgravity

Green

Aylott

Williams

et al. 2021

Life

View full text Add to dashboard Cite

Immune dysfunction has long been reported by medical professionals regarding astronauts suffering from opportunistic infections both during their time in space and a short period afterwards once back on Earth. Various species of prokaryotes onboard these space missions or cultured in a microgravity analogue exhibit increased virulence, enhanced formation of biofilms, and in some cases develop specific resistance for specific antibiotics. This poses a substantial health hazard to the astronauts confined in constant proximity to any present bacterial pathogens on long space missions with a finite number of resources including antibiotics. Furthermore, some bacteria cultured in microgravity develop phenotypes not seen in Earth gravity conditions, providing novel insights into bacterial evolution and avenues for research. Immune dysfunction caused by exposure to microgravity may increase the chance of bacterial infection. Immune cell stimulation, toll-like receptors and pathogen-associated molecular patterns can all be altered in microgravity and affect immunological crosstalk and response. Production of interleukins and other cytokines can also be altered leading to immune dysfunction when responding to bacterial infection. Stem cell differentiation and immune cell activation and proliferation can also be impaired and altered by the microgravity environment once more adding to immune dysfunction in microgravity. This review elaborates on and contextualises these findings relating to how bacteria can adapt to microgravity and how the immune system subsequently responds to infection.

show abstract

Acquired Antibiotic Resistance in Escherichia coli Exposed to Simulated Microgravity: Possible Role of Other Space Stressors and Adaptive Responses

Cited by 7 publications

References 6 publications

Reply to Mortazavi, “Acquired Antibiotic Resistance in Escherichia coli Exposed to Simulated Microgravity: Possible Role of Other Space Stressors and Adaptive Responses”

Reply to Mortazavi, “Acquired Antibiotic Resistance in Escherichia coli Exposed to Simulated Microgravity: Possible Role of Other Space Stressors and Adaptive Responses”

Skin microbiome considerations for long haul space flights

Immunity in Space: Prokaryote Adaptations and Immune Response in Microgravity

Contact Info

Product

Resources

About