Acquired angioedema in juvenile systemic lupus erythematosus: case-based review

Tekin, Zahide Ekici; Yener, Gülçin Otar; Yüksel, Selçuk

doi:10.1007/s00296-018-4088-z

Cited by 10 publications

(11 citation statements)

References 16 publications

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“…He demonstrated that the diagnosis of SLE and AE was concomitantly established for eight patients. 10 Seventeen patients were with low complement levels, five patients presented with glomerulonephritis, and three patients developed neuropsychiatric lupus. 10 Intriguingly, SLE patients found to have either low C1-INH 22 levels or high C1-INH autoantibodies 23 did not necessarily develop clinical AE.…”

Section: Discussionmentioning

confidence: 99%

“…Cacoub et al 9 described a "third type" of C1-INH-AAE in clinically quiescent SLE patients with transit low C1-INH antigenic and functional levels and hypocomplementemia, both of which normalized with resolution of AE after immunosuppressive therapy. Tekin et al 10 recently summarized 18 AAE cases associated with SLE. He demonstrated that the diagnosis of SLE and AE was concomitantly established for eight patients.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 and C1-INH-AAE. [7][8][9][10] Nonetheless, epidemiological studies of the two immune system-related conditions are lacking. Therefore, in this crosssectional study, we aimed to investigate the odds of developing AE in SLE populations compared to non-SLE populations in hospital settings in the US using a nationwide database.…”

mentioning

confidence: 99%

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Systemic Lupus Erythematosus and Angioedema: A Cross-Sectional Study From the National Inpatient Sample

Luo¹,

Fan²,

Jiang³

et al. 2019

Arch Rheumatol

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Objectives: This cross-sectional study aims to investigate the odds of developing angioedema (AE) in systemic lupus erythematosus (SLE) populations compared to non-SLE populations in hospital settings in the United States using a nationwide database. Materials and methods: We used the data from the National Inpatient Sample for the years 2012 to 2014. We constructed two models for multivariate logistic regression analysis. Model 1 was designed to adjust demographic information, while model 2 included each factor in model 1 and additionally accounted for AE-related comorbidities. Results: A total of 90,485 hospitalizations with an AE diagnosis were identified for the years 2012 to 2014, among which 1,505 hospitalizations had both SLE and AE. Compared to those without SLE, AE patients with SLE were younger and included more females. In AE hospitalizations, SLE was associated with higher odds of AE-related comorbidities including atopic disorder, leukocytoclastic vasculitis, eosinophilia, and infections. SLE was associated with higher odds of AE both as all inpatient diagnosis and as principal diagnosis (unadjusted odds ratio [OR] 3.24, 95% confidence interval [CI] 2.87-3.63, p<0.001, model 1 adjusted OR 2.54, 95% CI 2.26-2.86, p<0.001, model 2 adjusted OR 1.71, 95% CI 1.51-1.93, p<0.001). Conclusion: Our study demonstrates that SLE is associated with higher odds of having AE, including severe AE as the principal reason for inpatient admission. SLE is possibly an independent risk factor for AE.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Systemic Lupus Erythematosus and Angioedema: A Cross-Sectional Study From the National Inpatient Sample

Luo¹,

Fan²,

Jiang³

et al. 2019

Arch Rheumatol

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“…Patients presenting with angioedema crisis in the context of a disease such as SLE have improved with the administration of methylprednisolone pulses in 3 consecutive days in addition to maintenance therapy for the underlying disease [97].…”

Section: Acquired Angioedemamentioning

confidence: 99%

Phenocopies: Mimics of Inborn Errors of Immunity

Alonso-Bello¹,

Espinosa‐Padilla²,

Temix-Delfin³

et al. 2020

OALib

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A phenocopy is defined as a clinical non-inherited phenotype in an individual, with environmental induction, which is identical to the genetically determined phenotype of another. Until February 2017, the IUIS (International Union of Immunological Societies) reported in its classification 354 innate immunity errors and a final group (classification table IX) with conditions that are not part of the innate alterations and are called phenocopies. These are classified into two types, the associated with somatic mutations and those associated with auto-antibodies. The phenotypes that occur by any of the mechanisms mentioned are complex and varied. It is necessary to know the clinical manifestations of the pathologies classified in this group to enrich the possible differential diagnoses in individuals with suspected immunodeficiency.

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“…10 Angioedema can be a life-threatening condition for 15-33% SLE patients. 11 There shall be systematic and comprehensive handling management to reduce the ratio of mortality and morbidity in SLE emergency cases. However, in Indonesia, there are no guidelines or journals that explain about its treatment.…”

Section: Introductionmentioning

confidence: 99%

Angioedema in Systemic Lupus Erythematosus (SLE) in Emergency Setting: A Case Report

Mochtar

Alfaray

Irawaty³

et al. 2020

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Systemic Lupus Erythematosus (SLE) is an autoimmune disease that causes chronic inflammation with its characteristics of the autoantibody formation, attacks nuclear antigen. This disease may damage multisystem organs, its diagnoses, are barely implemented in the Emergency Department. However, cases of angioedema on SLE patient are quite uncommon not only in Indonesia but also globally. This article report an interesting case of 20 years old woman who came to the Emergency Department of Siti Khodijah Sepanjang Hospital with a swollen lips for three days. Both complaint and examination led to the diagnosis of SLE. However, because the incidence rate of angioedema on SLE is low, doctors tend to unconsider the appropriate diagnosis management and administration on this breathing problem caused by SLE.

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Acquired angioedema in juvenile systemic lupus erythematosus: case-based review

Cited by 10 publications

References 16 publications

Systemic Lupus Erythematosus and Angioedema: A Cross-Sectional Study From the National Inpatient Sample

Systemic Lupus Erythematosus and Angioedema: A Cross-Sectional Study From the National Inpatient Sample

Phenocopies: Mimics of Inborn Errors of Immunity

Angioedema in Systemic Lupus Erythematosus (SLE) in Emergency Setting: A Case Report

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