ACP Broadsheet No. 145: July 1995. Investigation of patients with autoimmune haemolytic anaemia and provision of blood for transfusion.

Sokol, Robert J.; Booker, D J; Stamps, R

doi:10.1136/jcp.48.7.602

Cited by 27 publications

(22 citation statements)

References 29 publications

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“…Usually, crossmatchcompatible RBCs cannot be found and "least incompatible" units will be transfused [5,14,15,16,17,20]. Unfortunately, the benefit of transfusion is only temporary since transfused RBCs will be destroyed at the same accelerated rate as the patient's own RBCs.…”

Section: Discussionmentioning

confidence: 99%

Intensive plasma exchange for severe autoimmune hemolytic anemia in a four-month-old infant

et al. 1999

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Section: Discussionmentioning

confidence: 99%

Intensive plasma exchange for severe autoimmune hemolytic anemia in a four-month-old infant

et al. 1999

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“…The records of the immunohematology department at the Trent Center were searched for patients with immune hemolysis occurring after transplantation. Three patients illustrating different immune mechanisms and complexities were chosen for detailed clinical and serologic study 2,3 …”

Section: Methodsmentioning

confidence: 99%

Posttransplant immune‐mediated hemolysis

et al. 2002

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“…In practical terms, therefore, the assay had no upper limit. The lower limit for IgG, correspond ing approximately to 26 molecules per red cell, was shown in other background studies to be well below the level at which the standard agglutination test becomes positive, namely approximately 150 molecules per cell in normal clinical practice [11] or approximately 60 molecules per cell using capillary methods [12].…”

Section: Discussionmentioning

confidence: 99%

A Quantitative ELISA for Measuring Red Cell-Bound Immunoglobulins

Hazlehurst

Hudson

Sokol³

1996

Acta Haematol

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An ELISA was developed for quantitating red-cell-bound IgG and IgA and its feasibility assessed on 50 blood donations and 32 clinical specimens with raised cell-bound IgG. Test and quality control samples and immunoglobulin standards (in red-cell lysate buffer) were assayed together. Calibration curves were derived from the standards, test values being read off and related to cell count. The working range was around 5-70 ng/ml, the upper limit being indefinitely extendable by dilution with lysate buffer. Ranges of results (and medians) in molecules per red cell were < 26-240 (40) for IgG and < 29-94 ( < 29) for IgA in the donations with 240-62,700 (1,200) for IgG and < 29-4,500 (73) for IgA in the clinical specimens. The method which can be adapted for any cell-bound immunoprotein should be particularly valuable in investigating autoimmune haemolysis.

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ACP Broadsheet No. 145: July 1995. Investigation of patients with autoimmune haemolytic anaemia and provision of blood for transfusion.

Cited by 27 publications

References 29 publications

Intensive plasma exchange for severe autoimmune hemolytic anemia in a four-month-old infant

Intensive plasma exchange for severe autoimmune hemolytic anemia in a four-month-old infant

Posttransplant immune‐mediated hemolysis

A Quantitative ELISA for Measuring Red Cell-Bound Immunoglobulins

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