Acoustofluidic stick-and-play micropump built on foil for single-cell trapping

Lin, Yang; Gao, Yuan; Wu, Mengren; Zhou, Renke; Chung, Daayun; Caraveo, Gabriela; Xu, Jie

doi:10.1039/c9lc00484j

Cited by 26 publications

(15 citation statements)

References 73 publications

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“…Very recently, a new type of acoustofluidic flexible micropump has been fabricated and reported by Lin et al [158]. Figure 7c,d illustrate the schematic of this micropump.…”

Section: Effect Of Flexibility On Pumpingmentioning

confidence: 99%

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

et al. 2019

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Miniaturization has been the driving force of scientific and technological advances over recent decades. Recently, flexibility has gained significant interest, particularly in miniaturization approaches for biomedical devices, wearable sensing technologies, and drug delivery. Flexible microfluidics is an emerging area that impacts upon a range of research areas including chemistry, electronics, biology, and medicine. Various materials with flexibility and stretchability have been used in flexible microfluidics. Flexible microchannels allow for strong fluid-structure interactions. Thus, they behave in a different way from rigid microchannels with fluid passing through them. This unique behaviour introduces new characteristics that can be deployed in microfluidic applications and functions such as valving, pumping, mixing, and separation. To date, a specialised review of flexible microfluidics that considers both the fundamentals and applications is missing in the literature. This review aims to provide a comprehensive summary including: (i) Materials used for fabrication of flexible microfluidics, (ii) basics and roles of flexibility on microfluidic functions, (iii) applications of flexible microfluidics in wearable electronics and biology, and (iv) future perspectives of flexible microfluidics. The review provides researchers and engineers with an extensive and updated understanding of the principles and applications of flexible microfluidics.

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“…Very recently, a new type of acoustofluidic flexible micropump has been fabricated and reported by Lin et al [158]. Figure 7c,d illustrate the schematic of this micropump.…”

Section: Effect Of Flexibility On Pumpingmentioning

confidence: 99%

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

et al. 2019

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“…The majority of microfluidic devices heavily rely on an external off-chip accessory or equipment (such as pumps and outlet systems) to maintain the operation condition, which has become a roadblock for their practical and commercial POC application. − To simplify the configuration and strengthen the practicability of the i ez Card, a single piece of Kimwipes (a kind of very commonly used laboratory tissue, Figure S6) was employed as the on-chip pump-free microchannel (Figure A,B). With the inherent capillary action of paper, the human serum is able to automatically transport along the Kimwipes.…”

Section: Results and Discussionmentioning

confidence: 99%

A Bendable Biofuel Cell-Based Fully Integrated Biomedical Nanodevice for Point-of-Care Diagnosis of Scurvy

et al. 2020

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Fully integrated nanodevices that allow the complete functional implementation without an external accessory or equipment are deemed to be one of the most ideal and ultimate goals for modern nanodevice design and construction. In this work, we demonstrate the first example of a bendable biofuel cell (BFC)-based fully integrated biomedical nanodevice with simple, palm-sized, easy-to-carry, pump-free, cost-saving, and easy-to-use features for the point-of-care (POC) diagnosis of scurvy from a single drop of untreated human serum (down to 0.2 μL) by integrating a bendable and disposable vitamin C/air microfluidic BFC (micro-BFC) (named iezCard) for self-powered vitamin C biosensing with a custom mini digital LED voltmeter (named iezBox) for signal processing and transmission, along with a ″built-in″ biocomputing BUFFER gate for intelligent diagnosis. Under the simplicity- and practicability-oriented idea, a cost-effective strategy (e.g., biomass-derived hierarchical micro–mesoporous carbon aerogels, screen-printed technique, a single piece of Kimwipes paper, LED display, and universal components) was implemented for nanodevice design rather than any top-end or pricey method (e.g., photolithography/electron-beam evaporation, peristaltic pump, wireless system, and 3D printing technique), which enormously reduces the cost of feedstock down to ∼USD 2.55 per integrated kit including a disposal iezCard (∼USD 0.08 per test) and a reusable iezBox (∼USD 2.47 for large-scale tests). These distinctive and attractive features allow such a fully integrated biomedical nanodevice to fully satisfy the basic requirements for POC diagnosis of scurvy from a single drop of raw human serum and make it particularly appropriate for resource-poor settings, where there is a lack of medical facilities, funds, and qualified personnel.

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“…In recent years, acoustically excited bubbles have attracted more and more interest due to their great potential for manipulating objects and fluids in microfluidic applications, which is typically excited by BAWs with relatively low frequencies (kHz) [ 48 , 49 , 50 , 51 ]. As mentioned in the theory section, when a bubble is actuated by acoustic waves, the objects near the bubble will experience both secondary radiation force and drag force.…”

Section: Baw-based Separationmentioning

confidence: 99%

Acoustic Microfluidic Separation Techniques and Bioapplications: A Review

Gao

Lin

et al. 2020

Micromachines

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Microfluidic separation technology has garnered significant attention over the past decade where particles are being separated at a micro/nanoscale in a rapid, low-cost, and simple manner. Amongst a myriad of separation technologies that have emerged thus far, acoustic microfluidic separation techniques are extremely apt to applications involving biological samples attributed to various advantages, including high controllability, biocompatibility, and non-invasive, label-free features. With that being said, downsides such as low throughput and dependence on external equipment still impede successful commercialization from laboratory-based prototypes. Here, we present a comprehensive review of recent advances in acoustic microfluidic separation techniques, along with exemplary applications. Specifically, an inclusive overview of fundamental theory and background is presented, then two sets of mechanisms underlying acoustic separation, bulk acoustic wave and surface acoustic wave, are introduced and discussed. Upon these summaries, we present a variety of applications based on acoustic separation. The primary focus is given to those associated with biological samples such as blood cells, cancer cells, proteins, bacteria, viruses, and DNA/RNA. Finally, we highlight the benefits and challenges behind burgeoning developments in the field and discuss the future perspectives and an outlook towards robust, integrated, and commercialized devices based on acoustic microfluidic separation.

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Acoustofluidic stick-and-play micropump built on foil for single-cell trapping

Abstract: Stick-and-play acoustic micropump and cell traps are built on a plastic film by printing microstructures using two-photon polymerization.

Cited by 26 publications

References 73 publications

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

A Bendable Biofuel Cell-Based Fully Integrated Biomedical Nanodevice for Point-of-Care Diagnosis of Scurvy

Acoustic Microfluidic Separation Techniques and Bioapplications: A Review

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