Acousto-mechanical behaviour of ex-vivo skin: Nonlinear and viscoelastic properties

Ghorbel-Feki, Halima; Masood, Ali; Caliez, Michaël; Gratton, Michel; Pittet, Jean Christophe; Lints, Martin; Santos, Serge Dos

doi:10.1016/j.crme.2018.12.005

Cited by 10 publications

(2 citation statements)

References 30 publications

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“…It is well known that highly non‐linear J‐shaped stress–strain behavior of human skin is attributed to its microstructural constituents. [ 48 ] Sliding and rearrangement of collagen and elastin fibers allow the skin to deform while maintaining its integrity and preventing damage. Elastin fibers contribute to the extensibility and reversible recoil to the skin, which allows it to withstand repeated mechanical deformations without suffering irreversible plastic damage at low loads.…”

Section: Resultsmentioning

confidence: 99%

A Skin‐Inspired Substrate with Spaghetti‐Like Multi‐Nanofiber Network of Stiff and Elastic Components for Stretchable Electronics

Hanif

Bag

Zabeeb

et al. 2020

Adv Funct Materials

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Mimicking the skin's non‐linear self‐limiting mechanical characteristics is of great interest. Skin is soft at low strain but becomes stiff at high strain and thereby can protect human tissues and organs from high mechanical loads. Herein, the design of a skin‐inspired substrate is reported based on a spaghetti‐like multi‐nanofiber network (SMNN) of elastic polyurethane (PU) nanofibers (NFs) sandwiched between stiff poly(vinyldenefluoride‐co‐trifluoroethylene) (P(VDF‐TrFE)) NFs layers embedded in polydimethylsiloxane elastomer. The elastic moduli of the stretchable skin‐inspired substrate can be tuned in a range that matches well with the mechanical properties of skins by adjusting the loading ratios of the two NFs. Confocal imaging under stretching indicates that PU NFs help maintain the stretchability while adding stiff P(VDF‐TrFE) NFs to control the self‐limiting characteristics. Interestingly, the Au layer on the substrate indicates a negligible change in the resistance under cyclic (up to 7000 cycles at 35% strain) and dynamic stretching (up to 35% strain), which indicates the effective absorption of stress by the SMNN. A stretchable chemoresistive gas sensor on the skin‐inspired substrate also demonstrates a reasonable stability in NO2 sensing response under strain up to 30%. The skin‐inspired substrate with SMNN provides a step toward ultrathin stretchable electronics.

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Section: Resultsmentioning

confidence: 99%

A Skin‐Inspired Substrate with Spaghetti‐Like Multi‐Nanofiber Network of Stiff and Elastic Components for Stretchable Electronics

Hanif

Bag

Zabeeb

et al. 2020

Adv Funct Materials

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show abstract

“…The modulus of longitudinal elasticity (Young's modulus) and transverse elasticity (Shear's modulus) defines the relationship between stress and strain in the skin. The modulus characterizes skin resistance to elastic elongation 22 …”

Section: Discussionmentioning

confidence: 99%

Non‐invasive evaluation of elasticity of skin with the processing of ultrasound images during ultraviolet radiation: An animal photoaging model

Estaji

Mokhtari‐Dizaji

Movahedin

et al. 2020

Photoderm Photoimm Photomed

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Objective The aim of this study was to provide a non‐invasive imaging method to evaluate the physical and mechanical parameters as a novelty method during skin photoaging. Methods In order to evaluate the process of skin damage, 25 mice (C57BL6) were exposed to UVB radiation (0.03 mW/cm2), 5 times a week for 5 weeks. The thickness of the epidermal and dermal layers was measured weekly from the ultrasound images (40 MHz). The elastic parameters of the skin were estimated from the processing of the sequential ultrasound images with the motion detection algorithm during the injury generation process. Results The thickening, Young modulus, and shear modulus of the dermal and epidermal layers during the UVB damage process significantly increased during the 5‐week study period (P < .05). In addition, the percentage of changes in the thickness of the epidermal layer (0.22 ± 0.01 mm in day 0 to 0.37 ± 0.02 mm in day 35) and dermal layer (0.57 ± 0.05 mm in day 0 to 0.90 ± 0.08 mm in day 35) increased by 68% and 57%, respectively. Furthermore, Young modulus (154.41 ± 8.8 kPa) was 11 times more than that of non‐irradiated skin (14.90 ± 2.2 kPa) and the shear modulus (2.33 ± 0.04 kPa) was 2.2 times more than non‐irradiated skin (1.06 ± 0.04 kPa). Conclusion With processing the sequential ultrasound images and extracting the thickening, the elasticity of the skin layers can detect skin lesions by UVB radiation.

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Advanced Ground Truth Multimodal Imaging Using Time Reversal (TR) Based Nonlinear Elastic Wave Spectroscopy (NEWS): Medical Imaging Trends Versus Non-destructive Testing Applications

Santos

2020

Applied and Numerical Harmonic Analysis

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Acousto-mechanical behaviour of ex-vivo skin: Nonlinear and viscoelastic properties

Cited by 10 publications

References 30 publications

A Skin‐Inspired Substrate with Spaghetti‐Like Multi‐Nanofiber Network of Stiff and Elastic Components for Stretchable Electronics

A Skin‐Inspired Substrate with Spaghetti‐Like Multi‐Nanofiber Network of Stiff and Elastic Components for Stretchable Electronics

Non‐invasive evaluation of elasticity of skin with the processing of ultrasound images during ultraviolet radiation: An animal photoaging model

Advanced Ground Truth Multimodal Imaging Using Time Reversal (TR) Based Nonlinear Elastic Wave Spectroscopy (NEWS): Medical Imaging Trends Versus Non-destructive Testing Applications

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