Acoustical and categorical tasks differently modulate activations of human auditory cortex to vowels

Harinen, Kirsi; Rinne, Teemu

doi:10.1016/j.bandl.2014.09.006

Cited by 3 publications

(10 citation statements)

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“…Second, in our previous studies increasing task difficulty (as indicated by decreasing task performance) in pitch ( Rinne et al, 2009 ) and location ( Rinne et al, 2012 ) discrimination tasks was not associated with strong activation modulations. Together, these results strongly suggest that the present activation differences between discrimination and 2-back tasks are due to specific requirements of these tasks and not due task difficulty as such (see also, Harinen and Rinne, 2014 ; Rinne et al, 2014 ).…”

Section: Discussionsupporting

confidence: 61%

“…Our previous studies have shown that activations in AC depend on the task so that activations in areas of anterior STG are enhanced during discrimination but not during n-back memory task, whereas activations in posterior STG and IPL are enhanced during n-back but not during discrimination. This anterior–posterior distinction is detected quite similarly when analogous discrimination and n-back tasks are performed on pitch-varying sounds ( Rinne et al, 2009 ), location-varying sounds ( Rinne et al, 2012 , 2014 ), or vowels ( Harinen and Rinne, 2014 ). Thus, it is evident that the main features of these activation patterns are due to characteristics and requirements of the discrimination and n-back tasks and not due to stimulus-dependent processing of pitch, location, or vowel information as such.…”

Section: Introductionmentioning

confidence: 84%

“…These results provide further evidence that IPL activations cannot be explained by sensitivity to location but that its activations depend strongly on the requirements of the task. (For a more detailed discussion on the functional significance of task-dependent activations during discrimination and n-back tasks see, Rinne et al, 2009 , 2012 , 2014 ; Harinen and Rinne, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

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Processing of pitch and location in human auditory cortex during visual and auditory tasks

2015

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The relationship between stimulus-dependent and task-dependent activations in human auditory cortex (AC) during pitch and location processing is not well understood. In the present functional magnetic resonance imaging study, we investigated the processing of task-irrelevant and task-relevant pitch and location during discrimination, n-back, and visual tasks. We tested three hypotheses: (1) According to prevailing auditory models, stimulus-dependent processing of pitch and location should be associated with enhanced activations in distinct areas of the anterior and posterior superior temporal gyrus (STG), respectively. (2) Based on our previous studies, task-dependent activation patterns during discrimination and n-back tasks should be similar when these tasks are performed on sounds varying in pitch or location. (3) Previous studies in humans and animals suggest that pitch and location tasks should enhance activations especially in those areas that also show activation enhancements associated with stimulus-dependent pitch and location processing, respectively. Consistent with our hypotheses, we found stimulus-dependent sensitivity to pitch and location in anterolateral STG and anterior planum temporale (PT), respectively, in line with the view that these features are processed in separate parallel pathways. Further, task-dependent activations during discrimination and n-back tasks were associated with enhanced activations in anterior/posterior STG and posterior STG/inferior parietal lobule (IPL) irrespective of stimulus features. However, direct comparisons between pitch and location tasks performed on identical sounds revealed no significant activation differences. These results suggest that activations during pitch and location tasks are not strongly affected by enhanced stimulus-dependent activations to pitch or location. We also found that activations in PT were strongly modulated by task requirements and that areas in the inferior parietal lobule (IPL) showed task-dependent activation modulations, but no systematic activations to pitch or location. Based on these results, we argue that activations during pitch and location tasks cannot be explained by enhanced stimulus-specific processing alone, but rather that activations in human AC depend in a complex manner on the requirements of the task at hand.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

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Processing of pitch and location in human auditory cortex during visual and auditory tasks

2015

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“…In addition, we detected inferior parietal lobe (IPL) perfusion to be linked to negative FTD. The IPL was previously suggested in the categorical representation of verbal information, obtained in the auditory system (e.g., the STG) . However, the specific role of the IPL for FTD dimensions has to be further evaluated.…”

Section: Discussionmentioning

confidence: 99%

Resting state perfusion in the language network is linked to formal thought disorder and poor functional outcome in schizophrenia

Stegmayer

Stettler

Strik

et al. 2017

Acta Psychiatr Scand

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ObjectiveFormal thought disorder (FTD) is a core symptom in schizophrenia. Here, we focus on resting state cerebral blood flow (rCBF) linked to dimensions of FTD.MethodsWe included 47 schizophrenia spectrum patients and 30 age‐ and gender‐matched healthy controls. We assessed FTD with the assessment of thought, language, and communication (TLC) and imaging on a 3T MRI scanner. Within patients, we tested the association of FTD dimensions and in a subgroup (n = 27) the association of functional outcome after 6 months with whole brain rCBF.ResultsNegative FTD was most prominently associated with perfusion within the superior temporal gyrus, while positive FTD was associated with perfusion within the supplementary motor area, and inferior frontal gyrus. Perfusion within the left supramarginal gyrus was associated with social functioning after 6 months.ConclusionsDistinguishable associations of rCBF with FTD dimensions point to distinct underlying pathophysiology. The location of aberrant perfusion patterns suggests that negative FTD might reflect defective access to semantic memory while positive FTD likely reflects defective suppression of irrelevant information during increased speech production. Finally, the neural correlates of thought block were also predictive of poor functional outcome. Thus, functional outcome and distinct FTD dimensions may share some pathophysiology.

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“…Attention-engaging auditory tasks, in general, are associated with enhanced activation in wide regions of auditory cortex (AC) along STG (Alho et al, 2014;Hall et al, 2000;Petkov et al, 2004;Rinne, 2010;Rinne et al, 2017;Rinne et al, 2005;Woods and Alain, 2009). Further, regions in anterior-middle STG show higher activation during (acoustical) discrimination than during (categorical) n-back memory tasks performed on identical stimuli, whereas during n-back tasks activation is higher in IPL Harinen and Rinne, 2014;Häkkinen et al, 2015;Rinne et al, 2009;Rinne et al, 2012). Such attention-and task-related modulations could easily interact with the effects associated with sensory-motor integration seen in homologous regions in posterior STG and IPL.…”

Section: Introductionmentioning

confidence: 94%

Interaction of the effects associated with auditory-motor integration and attention-engaging listening tasks

Wikman

Rinne

2019

Neuropsychologia

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Acoustical and categorical tasks differently modulate activations of human auditory cortex to vowels

Cited by 3 publications

References 35 publications

Processing of pitch and location in human auditory cortex during visual and auditory tasks

Processing of pitch and location in human auditory cortex during visual and auditory tasks

Resting state perfusion in the language network is linked to formal thought disorder and poor functional outcome in schizophrenia

Interaction of the effects associated with auditory-motor integration and attention-engaging listening tasks

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