Acoustic waves and the study of biochemical macromolecules and cells at the sensor–liquid interface

Čavić, Biljana A.; Thompson, Michael; Hayward, Gordon L.

doi:10.1039/a903236c

Cited by 149 publications

(26 citation statements)

References 140 publications

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“…From White, 1997. surface acoustic wave sensors, cantilevers, and quartz crystal microbalances that are useful for characterizing fluid viscosity and density, and detecting the presence of monolayers due to binding or growth, biopolymers or biomolecules, or even entire cells and tissue. A comprehensive review of the area requires an entirely separate effort, and in light of the reviews by Grate et al (1993), Marx (2003), and Lucklum and Hauptmann (2006), the other areas of sensor development for microfluidics, using optics, for example, as reported by Monat et al (2007), not to mention the work by McHale et al (2003) on Love wave and shear-horizontal wave sensors, the review of work on biosensors by Länge et al (2008) and biomolecular binding in acoustic sensing by Cavić et al (1999), the article by Ellis et al (2003) on predicting the effects of slip at the interface, and even the use of tailored electrode configurations such as the ones reported by Kondoh et al (2007), we focus upon actuation in lieu of sensing in most of what follows, because the recent developments in the application of acoustics at the microscale and beyond appear to principally be on actuation.…”

Section: Background a Acousticsmentioning

confidence: 99%

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

2011

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This article reviews acoustic microfluidics: the use of acoustic fields, principally ultrasonics, for application in microfluidics. Although acoustics is a classical field, its promising, and indeed perplexing, capabilities in powerfully manipulating both fluids and particles within those fluids on the microscale to nanoscale has revived interest in it. The bewildering state of the literature and ample jargon from decades of research is reorganized and presented in the context of models derived from first principles. This hopefully will make the area accessible for researchers with experience in materials science, fluid mechanics, or dynamics. The abundance of interesting phenomena arising from nonlinear interactions in ultrasound that easily appear at these small scales is considered, especially in surface acoustic wave devices that are simple to fabricate with planar lithography techniques common in microfluidics, along with the many applications in microfluidics and nanofluidics that appear through the literature.

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Section: Background a Acousticsmentioning

confidence: 99%

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

2011

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“…[2][3][4] The use of acoustic sensors is being extended to biological applications, 5,6 which often involve the detection of high molecular weight solutes such as proteins or DNA. The work described here was intended to characterize the response of the acoustic waveguide device with respect to increasing solute molecular weight, looking at the case in which the solute is not adsorbed to the device surface.…”

Section: Introductionmentioning

confidence: 99%

Acoustic determination of polymer molecular weights and rotation times

Melzak

Martin

Newton

et al. 2002

J Polym Sci B Polym Phys

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An acoustic waveguide device was shown to be sensitive to the molecular weight of poly(ethylene glycol) in solution over a molecular weight range determined by the operating frequency of the device. The acoustic device used generates a shear wave with displacement in the plane of the device surface and normal to the direction of propagation. Liquid over the device exhibits viscous coupling to the oscillating surface, affecting propagation of the acoustic wave. The propagation loss was shown to be directly proportional to the weight percentage of the solute. For a given weight percent of polymer in solution, the loss increased with increasing molecular weight until a maximum loss value was reached; this may be due to the fact that rotational times for polymer molecules increase with molecular weight until they reach a point at which the rotation is limited by the oscillation time on the device surface. The molecular weight at which the maximum loss value was attained was 10,000 g/mol for a device operating at 104 MHz and 3350 g/mol for a device operating at 331 MHz, implying a rotational time of 1 ns for each 2200 increase in molecular weight.

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“…These types of transducer rely on piezoelectric materials and convert a mechanical signal, namely a change in mass, into a shift of resonant frequency. Two excellent reviews of biosensing with acoustic resonators can be found, one dealing mainly with QCM [7], the second article [8] additionally covers SAW sensors. Both articles also present the reader with an introduction into the functional principles of mass-sensitive sensing and give a short summary of the theoretical background.…”

Section: Introductionmentioning

confidence: 99%