Acoustic Studies of Molecular Interactions of Prasugrel-HCl Drug with Methanol at Various Temperatures

Abstract

Prasugrel hydrochloride drug is a Piperazine derivative which is used to prevent blood clotting. Molecular Interactions of Prasugrel hydrochloride with methanol liquid have been investigated using experimental and computational techniques. The drug has been added in specific quantities to 99% pure Methanol liquid to obtain certain molarity mixture solutions ranging from 0.025 M to 0.2 M. The density, viscosity and ultrasonic velocity of the mixture solutions have been experimentally measured using standard techniques. From these values various parameters, such as Adiabatic Compressibility, Free Volume, Rao's constant, Relative Association, have been derived which show qualitatively the strength of intermolecular interactions between solute and solvent. Such studies have been done at various temperatures ranging from 303 K to 318 K. It has been found that at low temperatures and low concentrations, there is a strong interaction between the solute and the solvent. It is due to H-bonding between solvent and solute molecules. At higher temperatures and low concentrations the interaction is relatively weak. But, at elevated temperatures and high concentrations, the strength of molecular interaction again increases.