Acoustic streaming enabled moderate swimming exercise reduces neurodegeneration in
            <i>C. elegans</i>

Bhadra, Joyita; Sridhar, Nakul; Fajrial, Apresio Kefin; Hammond, Nia G.; Xue, Ding; Ding, Xiaoyun

doi:10.1126/sciadv.adf5056

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…By adjusting the duration and power intensity of SAW actuation, an optimal exposure setting has been found that substantially mitigates neurodegenerations in both models. This research underscores the nuanced relationship between exercise parameters and neuroprotection in C. elegans, unveiling the acoustofluidic gym as an instrumental tool for further inquiries in this domain [141,142]. More clinically, Gai et al have contributed an innovative, automated methodology for the selection of high-quality sperm, targeting the resolution of male infertility [143,144].…”

Section: Acoustofluidic Biophysical Therapymentioning

confidence: 87%

Acoustofluidic Actuation of Living Cells

Wu,

Gai,

Zhao

et al. 2024

Micromachines

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Acoutofluidics is an increasingly developing and maturing technical discipline. With the advantages of being label-free, non-contact, bio-friendly, high-resolution, and remote-controllable, it is very suitable for the operation of living cells. After decades of fundamental laboratory research, its technical principles have become increasingly clear, and its manufacturing technology has gradually become popularized. Presently, various imaginative applications continue to emerge and are constantly being improved. Here, we introduce the development of acoustofluidic actuation technology from the perspective of related manipulation applications on living cells. Among them, we focus on the main development directions such as acoustofluidic sorting, acoustofluidic tissue engineering, acoustofluidic microscopy, and acoustofluidic biophysical therapy. This review aims to provide a concise summary of the current state of research and bridge past developments with future directions, offering researchers a comprehensive overview and sparking innovation in the field.

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Section: Acoustofluidic Biophysical Therapymentioning

confidence: 87%

Acoustofluidic Actuation of Living Cells

Wu,

Gai,

Zhao

et al. 2024

Micromachines

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Airborne Acoustic Vortex End Effector‐Based Contactless, Multi‐Mode, Programmable Control of Object Surfing

Li,

et al. 2024

Adv Materials Technologies

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Tweezers based on optical, electric, magnetic, and acoustic fields have shown great potential for contactless object manipulation. However, current tweezers designed for manipulating millimeter‐sized objects such as droplets, particles, and small animals exhibit limitations in translation resolution, range, and path complexity. Here, a novel acoustic vortex tweezers system is introduced, which leverages a unique airborne acoustic vortex end effector integrated with a three‐degree‐of‐freedom (DoF) linear motion stage, for enabling contactless, multi‐mode, programmable manipulation of millimeter‐sized objects. The acoustic vortex end effector utilizes a cascaded circular acoustic array, which is portable and battery‐powered, to generate an acoustic vortex with a ring‐shaped energy pattern. The vortex applies acoustic radiation forces to trap and spin an object at its center, simultaneously protecting this object by repelling other materials away with its high‐energy ring. Moreover, The vortex tweezers system facilitates contactless, multi‐mode, programmable object surfing, as demonstrated in experiments involving trapping, repelling, and spinning particles, translating particles along complex paths, guiding particles around barriers, translating and rotating droplets containing zebrafish larvae, and merging droplets. With these capabilities, It is anticipated that the tweezers system will become a valuable tool for the automated, contactless handling of droplets, particles, and bio‐samples in biomedical and biochemical research.

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Wireless Frequency‐Multiplexed Acoustic Array‐Based Acoustofluidics

Li,

Bo,

et al. 2024

Adv Materials Technologies

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Acoustofluidics has shown great potential in enabling on‐chip technologies for driving liquid flows and manipulating particles and cells for engineering, chemical, and biomedical applications. To introduce on‐demand liquid sample processing and micro/nano‐object manipulation functions to wearable and embeddable electronics, wireless acoustofluidic chips are highly desired. This paper presents wireless acoustofluidic chips to generate acoustic waves carrying sufficient energy and achieve key acoustofluidic functions, including arranging particles and cells, generating fluid streaming, and enriching in‐droplet particles. To enable these functions, the wireless acoustofluidic chips leverage mechanisms, including inductive coupling‐based wireless power transfer (WPT), frequency multiplexing‐based control of multiple acoustic waves, and the resultant acoustic radiation and drag forces. For validation, the wirelessly generated acoustic waves are measured using laser vibrometry when different materials (e.g., bone, tissue, and hand) are inserted between the WPT transmitter and receiver. Moreover, the wireless acoustofluidic chips successfully arrange nanoparticles into different patterns, align cells into parallel pearl chains, generate streaming, and enrich in‐droplet microparticles. This research is anticipated to facilitate the development of embeddable wireless on‐chip flow generators, wearable sensors with liquid sample processing functions, and implantable devices with flow generation and acoustic stimulation abilities for engineering, veterinary, and biomedical applications.

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Acoustic streaming enabled moderate swimming exercise reduces neurodegeneration in C. elegans

Cited by 3 publications

References 61 publications

Acoustofluidic Actuation of Living Cells

Acoustofluidic Actuation of Living Cells

Airborne Acoustic Vortex End Effector‐Based Contactless, Multi‐Mode, Programmable Control of Object Surfing

Wireless Frequency‐Multiplexed Acoustic Array‐Based Acoustofluidics

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