High-intensity focused ultrasound (FUS) is a noninvasive technique for ther-1 mal or mechanical treatment of tissues that can lie deep within the body, with a 2 growing body of FDA-approved indications. There is a pressing need for methods to 3 rapidly and quantitatively map FUS beams for quality assurance in the clinic, and to 4 accelerate research and development of new FUS systems and techniques. However, 5 conventional ultrasound pressure beam mapping instruments including hydrophones 6 and optical techniques are slow, not portable, and expensive, and most cannot map 7 beams at actual therapeutic pressure levels. Here, we report a rapid projection imag-8 ing method to quantitatively map FUS pressure beams based on continuous-wave 9 background-oriented schlieren (CW-BOS) imaging. The method requires only a wa-10 ter tank, a background pattern and a camera, and uses a multi-layer deep neural 11 network to reconstruct beam maps. Results at two FUS frequencies show that CW-12 BOS imaging can produce high-resolution quantitative projected FUS pressure maps 13 in under ten seconds, that the technique is linear and robust to beam rotations and 14 translations, and that it can accurately map aberrated beams. 15 Keywords: Schlieren, Beam mapping, Therapeutic ultrasound, Deep learning a will.grissom@vanderbilt.edu 2 I. INTRODUCTION 16 Focused ultrasound (FUS) with pressures up to several megapascals (MPa) is a noninva-17 sive therapeutic modality that has a broad range of established and emerging applications, 18including tumor and fibroid destruction, drug delivery, brain surgery 1 , blood-brain barrier 19 opening and neuromodulation. Ablative FUS was recently FDA-approved for treating essen-20 tial tremor 2 , and clinical trials are ongoing to establish its safety and efficacy in delivering 21 Alzheimers disease drugs via blood brain barrier opening 3 . The method can be highly se-22 lective and can produce very sharp margins as narrow as six cells between an ablated lesion 23 and viable tissue 4 . To maximize FUS's therapeutic benefit, it is required to know how much 24 acoustic energy is delivered and where it is delivered, with high spatial accuracy and pre-25 cision. Furthermore, for therapeutic efficacy and safety it is necessary to assess whether 26 the FUS system output changes between treatments, and to check for system failures which 27 could dangerously alter energy delivery. Experts have recommended that rigorous quanti-28 tative beam mapping be performed on clinical systems two to three times monthly 5 . For 29 these reasons, the ability to quantitatively map the acoustic beam in two or three spatial 30 dimensions in the clinic is essential, and it is important for the safety and reproducibility 31 of FUS treatments that instruments for rapid field characterization become available. FUS 32 beam mapping is also essential for research and the development of new FUS technologies 33 and techniques, such as new therapeutic transducers 6 , methods to propagate FUS beams 34 through the skull and other bones 7...