Acoustic Sampling for Mass Spectrometry

Sample-Specific MS/MS Methods in High-Throughput Mass Spectrometry

“…However, the widespread adoption of LC-MS in high-throughput settings has been impeded by its relatively low analysis throughput, primarily due to the time required for complete elution from chromatographic columns . In recent years, the emergence of chromatographic-free high-throughput mass spectrometry (HT-MS) technologies has expanded the utilization of MS in large sample set analysis . These platforms, including matrix-assisted laser desorption ionization (MALDI), laser diode thermal desorption (LDTD), direct analysis in real-time (DART), desorption electrospray ionization (DESI), , matrix-assisted laser desorption electrospray ionization (MALDESI), liquid atmospheric pressure (LAP)-MALDI, acoustic mist ionization (AMI), and acoustic ejection mass spectrometry (AEMS), , have demonstrated significant improvements in sample readout speed, exceeding 10-fold compared to LC-MS, enabling the analysis of over 50 000 samples per day.…”