Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease

Kiani, A.; Brun, Vanessa; Lainé, Fabrice; Turlin, Bruno; Morçet, Jeff; Michalak, Sophie; Gruyer, Antonia Le; Legros, Ludivine; Bardou-Jacquet, Édouard; Gandon, Y.; Moirand, Romain

doi:10.3748/wjg.v22.i20.4926

Cited by 37 publications

(21 citation statements)

References 45 publications

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“…Several studies with patients with liver diseases show a significant influence of alcohol consumption on elastography [30]. In our study on a random sample with healthy volunteers, we revealed no significant influence of alcohol on elastography.…”

Section: Discussioncontrasting

confidence: 51%

Comparison of Liver Shear Wave Elastography Measurements using Siemens Acuson S3000, GE LOGIQ E9, Philips EPIQ7 and Toshiba Aplio 500 (Software Versions 5.0 and 6.0) in Healthy Volunteers

et al. 2018

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Aim To compare ARFI-based elastography procedures of the GE LOGIQ E9, Philips EPIQ7, and Toshiba Aplio 500 (versions 5.0 and 6.0) ultrasound scanners with the Siemens Acuson S3000 reference scanner in subjects with healthy livers, taking various impact factors into account. Materials and Methods The study consisted of two subsequent study parts. Study 1 (n = 205) evaluated the 2D-SWE techniques of GE and Toshiba 5.0 and the pSWE technique of the Philips scanner against the reference scanner Siemens. Study 2 (n = 113) evaluated Toshiba 6.0 against Siemens in a different cohort. Out of 433 study participants in both studies, 318 (M:F = 122:196) met the inclusion criteria. Elastography measurements were performed in the right lobe of the liver at depths of 3, 5 and 7 cm. At each depth, five measurements were acquired with the Siemens and Philips scanners and one measurement each with the GE and Toshiba machines. Results The Philips (r = 0.58, p < 0.0001) and the GE (r = 0.63, p < 0.0001) scanners showed the strongest correlation of shear wave velocities between Siemens and comparator scanners, at a depth of 5 cm. We found the strongest relationship with Toshiba (software version 6.0) at a depth of 3 cm (r = 0.57, p < 0.0001). Toshiba software version 5.0 did not give satisfactory results. The factors of sex and BMI showed scanner-specific differences in the values measured (p < 0.05). The age of the subjects did not seem to have any effect. Conclusion With the exception of Toshiba software version 5.0, all of the scanners we tested can be recommended without reservation for comparative ultrasound elastography of the healthy liver at measurement depths of 3 cm up to 5 cm.

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Section: Discussioncontrasting

confidence: 51%

Comparison of Liver Shear Wave Elastography Measurements using Siemens Acuson S3000, GE LOGIQ E9, Philips EPIQ7 and Toshiba Aplio 500 (Software Versions 5.0 and 6.0) in Healthy Volunteers

et al. 2018

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“…We have come across very limited literature about ARFI elastography in alcoholic liver diseases, but it has been validated in liver fibrosis of other etiologies, namely, viral hepatic fibrosis, nonalcoholic steatohepatitis, etc., Two studies were available in the literature addressing the use of ARFI elastography in alcoholic liver fibrosis: one by Zhang et al in China (2014) on 112 patients and other by Kiani et al in France (2016) on 83 patients from deaddiction centers. [1819] In our study, we observed the SW velocity cutoffs of 1.37 m/s for significant fibrosis, 1.51 m/s for severe fibrosis, and 1.87 m/s for cirrhosis of liver. The cutoffs from meta-analysis were comparable to our study, whereas the observations of Zhang et al were lower and observations of Kiani et al were higher [Table 2].…”

Section: Discussionmentioning

confidence: 50%

Acoustic radiation force impulse elastography of liver as a screening tool for liver fibrosis in alcoholic liver disease

Hittalamani

Lakhkar

Pattanashetti

et al. 2019

Indian Journal of Radiology and Imaging

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Context: Acoustic radiation force impulse (ARFI) elastography is a noninvasive and quantitative technique for diagnosis of liver fibrosis. To the best of our knowledge, there are only two studies reported in literature for evaluation of alcoholic liver disease using ARFI. Aims: The aim of this study was to evaluate the diagnostic performance of ARFI elastography for assessing liver fibrosis in alcoholic liver disease and compare it with biochemical indices aspartate transaminase-to-platelet ratio index (APRI) and fibrosis-4 Index (FIB-4) using histopathology as the reference standard. Settings and Design: Institutional cross-sectional study. Methods and Materials: The patients visiting our hospital over a period of 2 years with a high-risk consumption of alcohol (>40 g/day for men and >20 g/day for women for a cumulative period of more than 5 years) were subjected to ARFI elastography of liver, Liver Function Tests (to calculate APRI and FIB-4 indices), and liver biopsy. Statistical Analysis Used: Area under the receiver operating characteristic (AUROC) curve analysis, Kruskal--Wallis test for ANOVA. Results: A total of 50 patients of chronic alcoholic liver disease were evaluated with ARFI elastography, which performed better than the biochemical indices in distinguishing cirrhosis of the liver ( F = 4) from the severe fibrosis ( F ≥ 3) with area under the receiver operating characteristic of 0.97, whereas for significant fibrosis ( F ≥ 2) and severe fibrosis (F ≥ 3), it was comparable to the biochemical indices with AUROC of 0.65 and 0.70. In our study, the median shear wave velocity cutoff values were 1.37 m/s, 1.51 m/s, and 1.87 m/s for F ≥ 2, F ≥ 3, and F = 4 fibrosis stages, respectively. Conclusions: ARFI elastography is a noninvasive, reliable, and repeatable diagnostic test for grading of liver fibrosis. It performs better than the biochemical indices to differentiate severe fibrosis and cirrhosis of liver.

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“…pSWE can be used in HBV, HCV, hepatic toxicity, alcoholic liver disease, and autoimmune hepatitis related liver fibrosis[37–39]. It can also be used as a screening tool for fibrosis detection at early stages[40], although evidence of benefit in this setting is limited.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Principles of ultrasound elastography

et al. 2018

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Tissue stiffness has long been known to be a biomarker of tissue pathology. Ultrasound elastography measures tissue mechanical properties by monitoring the response of tissue to acoustic energy. Different elastographic techniques have been applied to many different tissues and diseases. Depending on the pathology, patient-based factors, and ultrasound operator-based factors, these techniques vary in accuracy and reliability. In this review, we discuss the physical principles of ultrasound elastography, discuss differences between different ultrasound elastographic techniques, and review the advantages and disadvantages of these techniques in clinical practice.

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Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease

Abstract: ARFI is an accurate, non-invasive and easy method for assessing liver fibrosis in patients with ALD undergoing alcoholic detoxification.

Cited by 37 publications

References 45 publications

Comparison of Liver Shear Wave Elastography Measurements using Siemens Acuson S3000, GE LOGIQ E9, Philips EPIQ7 and Toshiba Aplio 500 (Software Versions 5.0 and 6.0) in Healthy Volunteers

Comparison of Liver Shear Wave Elastography Measurements using Siemens Acuson S3000, GE LOGIQ E9, Philips EPIQ7 and Toshiba Aplio 500 (Software Versions 5.0 and 6.0) in Healthy Volunteers

Acoustic radiation force impulse elastography of liver as a screening tool for liver fibrosis in alcoholic liver disease

Principles of ultrasound elastography

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