Acoustic Radiation Force Impulse-Imaging for the evaluation of the thyroid gland: A limited patient feasibility study

Friedrich‐Rust, Mireen; Romenski, O; Meyer, Gesine; Dauth, Nina; Holzer, Katharina; Grünwald, Frank; Kriener, Susanne; Herrmann, Eva; Zeuzem, Stefan; Bojunga, Joerg

doi:10.1016/j.ultras.2011.06.012

Cited by 112 publications

(96 citation statements)

References 28 publications

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“…The stiffer a tissue is, the greater is the shear wave velocity. ARFI was applied to diffuse thyroid pathology evaluation with good results [14,15]. Differently from the preliminary experience published by Friederich-Rust et al [14] who used a curved array probe, more recently a linear probe at 9-12 MHz, optimal for thyroid tissue evaluation, is now available.…”

Section: Discussionmentioning

confidence: 99%

“…They concluded that ARFI imaging has high sensitivity and specificity in evaluating benign and malignant thyroid nodules and therefore a good diagnostic value in clinical applications [16]. More recently, Friedrich-Rust et al [14] compared ARFI and RTE to differentiate benign from malignant thyroid nodules. They showed that the combination of RTE with ARFI imaging improved specificity for the diagnosis of malignant nodules from 72 (RTE alone) to 92 % but sensitivity was reduced from 76 to 58 %.…”

Section: Discussionmentioning

confidence: 99%

“…Increased reliance on nodule stiffness quantification is therefore needed to bring about a standardization of diagnostic criteria. Acoustic radiation force impulse technology (ARFI), already used in different fields, has also been applied to evaluate diffuse thyroid diseases, [14,15], and recently to differentiate thyroid nodules such as in the study performed by Gu et al [16].…”

Section: Introductionmentioning

confidence: 99%

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Prospective evaluation of acoustic radiation force impulse technology in the differentiation of thyroid nodules: accuracy and interobserver variability assessment

et al. 2014

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Purpose The aim of this study is to assess the diagnostic efficacy and interobserver agreement of acoustic radiation force impulse (ARFI) elasticity imaging in differentiating thyroid nodules. Methods In our study, 74 consecutive patients (52 females, 22 males; age range 27-77 years, mean: 41 years) with 82 thyroid nodules (60 benign nodules, and 22 malignant) were examined by two radiologists with different experience. Patients underwent either cytology using fine needle aspiration cytology or thyroid surgery. The diagnostic performance of the two operators at ARFI with sensitivity, specificity, positive predictive and negative predictive value, and ROC curves was estimated. Interreader variability between the two operators was defined using Cohen's k.Results According to receiver operating characteristics ROC curves (AUROC = 0.86 for observer 1; 0.81 for observer 2) sensitivity, specificity, PPV and NPV of reader 1 and 2 were respectively: 90, 75, 90.91 and 96.55 %; (cutoff value of shear wave: 2.455 m/s); 90, 72, 90 and 96.90 % (cut-off value shear wave: 2.365 m/s). Concordance between the two operators was good (k = 0.755). Conclusions This work is a feasibility study evaluating ARFI imaging. Its results suggest that ARFI imaging is a reproducible method which can be utilized with good diagnostic performance in the thyroid for discriminating benign and malignant nodules using the cut-off value of 2.455 m/s. However, larger studies are needed to validate this method.Keywords Acoustic radiation force impulse (ARFI) Á Elastography Á Benign thyroid nodules Á Malignant thyroid nodules Á Ultrasound Riassunto Scopo Lo scopo di questo studio è la valutazione della efficacia diagnostica e della concordanza inter-osservatore dell'imaging elastografico ARFI, per la differenziazione di noduli tiroidei. Metodo Nel nostro studio, 74 pazienti consecutivi (52 femmine, 22 maschi; range di età 22-77 anni, età media 41 anni) con 82 noduli tiroidei (60 noduli benigni e 22 maligni), sono stati esaminati da due radiologi con diverso livello di esperienza. I pazienti sono stati sottoposti o a citologia aspirativa con ago sottile (FNAC), o a chirurgia tiroidea. La performance diagnostica dei due operatori all' ARFI è stata stimata con la sensibilità, la specificità, il valore predittivo positivo (VPP) e negativo (VPN), attraverso le curve ROC (receiver operating characteristics). La variabilità inter-osservatore tra i due operatori, è stata definita usando la kappa di Cohen. (2014( ) 17:13-20 DOI 10.1007 Risultati Secondo le curve ROC (AUROC = 0.86 per il primo osservatore; 0.81 per il secondo osservatore) la sensibilità, la specificità, il VPP e il VPN per gli osservatori 1 e 2, erano rispettivamente: 90, 75, 90,91, e 96.55 %; (valore medio di shear wave: 2.455 m/s); 90, 72, 90 e 96.90 % (valore medio di shear wave: 2.365 m/s). La concordanza tra I due operatori era buona (k = 0.755). Conclusioni Questo lavoro è uno studio preliminare che valuta l'imaging elastografico con Acustic Radiation Force Impulse. I risultati sug...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prospective evaluation of acoustic radiation force impulse technology in the differentiation of thyroid nodules: accuracy and interobserver variability assessment

et al. 2014

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“…A large proportion of the studies describe the method's diagnostic performance in thyroid cancer [17][18][19][20][21]. Only a few papers discuss SWV's usefulness in diffuse thyroid pathologies, with moderate results [22,23].…”

Section: Discussionmentioning

confidence: 99%

Acoustic Radiation Force Impulse quantitative elastography: a new noninvasive technique for the evaluation of parotid glands. A preliminary study in controls and in patients with irradiated nasopharyngeal carcinoma.

et al. 2015

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Aim: We aim to define the values of the shear wave velocity (SWV) in the normal parotid glands (PG) and to identify the modifications of tissue stiffness in patients with irradiated nasopharyngeal carcinoma. Material and methods: Sixty normal parotid glands pertaining to 30 healthy volunteers and 40 pathological parotid glands pertaining to 20 patients who had had underwent radiation therapy for nasopharyngeal carcinoma were included in this study. The patients underwent a B mode ultrasonography examination and the volume of the parotid gland was determined. A subsequent Acoustic Radiation Forde Impulse Imaging (ARFI) examination was performed and the SWV were determined for the central and the periphery of the glandular parenchyma. Results: The mean volume of the gland in the volunteers' group (12.02±0.6 ml) was significantly higher than in the group of patients who underwent radiation therapy (10.3±0.74 ml) (p<0.0001). The SWV values in the normal group were lower compared to the patients group (1.54±0.6 m/s vs. 1.76±0.73 m/s, p<0.0001). Conclusion: Elastography using the ARFI technique constitutes an objective method used for the evaluation of glandular stiffness in both normal and post radiotherapy glands. The SWV values determined in patients who underwent head and neck radiotherapy are increased, indicating a greater tissue stiffness thereby implying a structural transformation of the glandular parenchyma.

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“…Also some new techniques, such as elastography, are believed to improve the reliability of diagnosis. This has been described as a very useful tool in differentiating between benign and malignant thyroid lesions [9][10][11] and diagnostics of other thyroid diseases, such as Graves' disease, chronic or subacute thyroiditis [12][13][14]. Especially shear wave elastography (SWE), a new variant of thyroid imaging, is considered as more objective, reliable and reproducible.…”

Section: Introductionmentioning

confidence: 99%

Jak typować guzy do biopsji aspiracyjnej cienkoigłowej w wolu wieloguzkowym? Rola konwencjonalnej ultrasonografii oraz elastografii fali poprzecznej — badanie pilotażowe

Woliński¹,

Szczepanek‐Parulska²,

Stangierski³

et al. 2014

Endokrynologia Polska

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Introduction: The wide prevalence and relatively low malignancy ratio of thyroid nodular disease (TND) make the selection of suspicious lesions for fine-needle aspiration biopsy (FNAB) a vital problem in endocrinology. Apart from the decision as to whether FNAB is necessary, there is often a second problem -which nodule or nodules to choose in a case of multinodular goitre (MNG), when the number of lesions may be high. The aim of this study was to compare the usefulness of conventional ultrasonography (US) to that of a novel method of tissue stiffness assessment -shear wave elastography (SWE) -in differentiating between malignant and benign nodules and in selecting the most suspicious lesions in MNG. Material and methods: Patients with MNG, referred for thyroidectomy irrespectively of indications for surgery, underwent thyroid US and SWE examination before surgery, between August and December 2010. Results of these examinations were correlated with the histopathological outcomes. Results: 80 patients with 339 thyroid nodules were included. Ten thyroid cancers (TCs) in ten patients were diagnosed in histopathology. All ten cancers were the least elastic lesions in MNG (using quantitative data on maximal tissue stiffness). Four cancers appeared as the biggest lesions in MNG, while one was equally the biggest in a particular goitre (there were other lesions of the same size) taking into account maximal diameter. Three of ten cancers possessed the highest number of suspicious features in MNG, a further four had the highest number equally, with at least one other lesion in the same goitre. Conclusions: On the basis of our results, the relatively high stiffness of a lesion compared to other nodules from the same MNG should be considered as a strong argument for choosing that particular one for FNAB. (Endokrynol Pol 2014; 65 (2): 114-118)

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Acoustic Radiation Force Impulse-Imaging for the evaluation of the thyroid gland: A limited patient feasibility study

Cited by 112 publications

References 28 publications

Prospective evaluation of acoustic radiation force impulse technology in the differentiation of thyroid nodules: accuracy and interobserver variability assessment

Prospective evaluation of acoustic radiation force impulse technology in the differentiation of thyroid nodules: accuracy and interobserver variability assessment

Acoustic Radiation Force Impulse quantitative elastography: a new noninvasive technique for the evaluation of parotid glands. A preliminary study in controls and in patients with irradiated nasopharyngeal carcinoma.

Jak typować guzy do biopsji aspiracyjnej cienkoigłowej w wolu wieloguzkowym? Rola konwencjonalnej ultrasonografii oraz elastografii fali poprzecznej — badanie pilotażowe

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