Lightweight panels are very common in the building, aerospace and automotive industry, and their acoustic insulation properties are well studied; nevertheless, low frequency noise is inherently difficult to deal with, mainly due to its high penetration. To encounter this issue, several treatments have been proposed in the form of perforated plates, meta-surfaces and acoustic/elastic meta-materials among others. Despite, the continuous attempts, none of the available solutions has indicated an outstanding performance in the low frequency range. On the other hand, boundary conditions of a vibrating panel are known to have an influence on the sound transmission loss (STL). Driven by the recently extended standards to include frequencies as low as 50 Hz, and the academic community debate about the reliability of lowfrequency measurements in reverberant chambers, STL improvement in the region of the first panel resonance is investigated in this paper, considering a panel supported on elastic mounts. Following a general vibration isolation approach, the fundamental eigenfrequency of the panelmount system is reduced and is explicitly selected below the threshold of human hearing. STL predictions are accomplished utilizing a Finite Element (FE) vibroacoustic model that simulates real test room conditions. Compared to the commonly used models of a baffled plate radiating to infinity, this detailed approach allows not only a more accurate calculation of STL but also reveals the potential issues emerging during laboratory measurements. COMPDYN 2021 8 th ECCOMAS Thematic Conference on Computational Methods in Structural Dynamics and Earthquake Engineering M. Papadrakakis, M. Fragiadakis (eds.