2016
DOI: 10.1038/srep38967
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Acoustic micro-tapping for non-contact 4D imaging of tissue elasticity

Abstract: Elastography plays a key role in characterizing soft media such as biological tissue. Although this technology has found widespread use in both clinical diagnostics and basic science research, nearly all methods require direct physical contact with the object of interest and can even be invasive. For a number of applications, such as diagnostic measurements on the anterior segment of the eye, physical contact is not desired and may even be prohibited. Here we present a fundamentally new approach to dynamic ela… Show more

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Cited by 115 publications
(144 citation statements)
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“…Most recently, technological innovations in piezoceramic materials from the same group have enabled the realization of high-power ultrasound transducers capable of air-coupled ARF excitation [95]. Such transducers, recently demonstrated for OCE in ex vivo porcine cornea [96], present intriguing possibilities for noncontact OCE.…”
Section: Loading Methodsmentioning
confidence: 99%
“…Most recently, technological innovations in piezoceramic materials from the same group have enabled the realization of high-power ultrasound transducers capable of air-coupled ARF excitation [95]. Such transducers, recently demonstrated for OCE in ex vivo porcine cornea [96], present intriguing possibilities for noncontact OCE.…”
Section: Loading Methodsmentioning
confidence: 99%
“…Moreover, repetitive imaging of flow can yield not only velocity, but also the total flow [175,176]. Another functional extension allows for determination of tissue elasticity [177]. In developmental biology, high speed imaging with FDML lasers has demonstrated time-resolved imaging of heart motion [178,179].…”
Section: Applicationsmentioning
confidence: 99%
“…28 There are some limitations in our work as well. The surface wave equation does not take into account the corneal viscoelastic nonlinearity, 25,28 corneal curvature and thickness, 29 aqueous humor, 30 dispersion of the elastic wave, 31,32 or corneal mechanical anisotropy. 24,33 Additionally, the limited spatial and temporal data points resulted in the large variance in measured corneal biomechanical properties at 20 mmHg (stiff conditions), and the limited bandwidth of the air-pulse induced waves (below 1 kHz) combined with limited number of data points prevented dispersion analysis of the elastic wave.…”
mentioning
confidence: 99%
“…There are still several steps for improvement, which are the focus of our future work. For example, utilizing the both scans of the resonant scanner, 21 dispersion analysis 31,32,34 with a more rigorous mechanical wave model 31 will enable more accurate elasticity measurements. Acoustic techniques can also provide noncontact measurement of corneal biomechanical parameters, 33 but the presence of the coupling medium can be uncomfortable for in vivo corneal applications.…”
mentioning
confidence: 99%
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