Acoustic Droplet Vaporization in Biology and Medicine

Lin, Chung-Yin; Pitt, William G.

doi:10.1155/2013/404361

Cited by 79 publications

(80 citation statements)

References 85 publications

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“…This circulation of the dynamic system has been reported by Sheeran et al [45] and observed with PFP and PFH nanoparticle droplets in water at 25 °C and 37 °C [46].…”

Section: Bubble Growthsupporting

confidence: 81%

“…The gas bubble nucleated will be continuous to grow without the limitation in terms of the heat after the increasing internal pressure of droplets ultimately exceeds the vapor pressure in the ultrasonic field, because the heat is adequate to converted into the energy demanded for satisfying the formation of the gas phase [46]. This circulation of the dynamic system has been reported by Sheeran et al [45] and observed with PFP and PFH nanoparticle droplets in water at 25 °C and 37 °C [46].…”

Section: Bubble Growthmentioning

confidence: 68%

“…For small droplets trapped by elastic lipid shells, however, even though the vapor pressure of liquid droplets is greater than its surrounding pressure in the surrounding liquid, the small droplets still have not changed to gas because of Laplace pressure, which contributes to the local pressure imposed on the interior fluid of droplets due to the surface tension [44][45][46].…”

Section: Thermodynamics Of Vaporizationmentioning

confidence: 99%

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Phase-transition Perfluorocarbon Nanoparticles for Ultrasound Molecular Imaging and Therapy

Xu¹,

Cao²,

Xu³

et al. 2015

Nano BioMed ENG

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Recently, the advances in perfluorocarbon nanoparticles have been introduced to expand the diagnostic and therapeutic capability of ultrasound molecular imaging, a non-invasive diagnostic imaging, which passed from robust anatomical presentation to detection of physiological processes and recognition of specific tissue epitopes at the cellular level. The good properties of perfluorocarbon nanoparticles, such as nontoxicity, small size, phase-shift capability, etc., have been resulted in tremendous potential prospects in clinical application. Herein, this review focuses on the mechanisms of perfluorocarbon nanoparticles in terms of phase transition and ultrasonic theranostic. And the potential applications of perfluorocarbon nanoparticles in ultrasound medicine are also discussed.

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“…This circulation of the dynamic system has been reported by Sheeran et al [45] and observed with PFP and PFH nanoparticle droplets in water at 25 °C and 37 °C [46].…”

Section: Bubble Growthsupporting

confidence: 81%

Section: Bubble Growthmentioning

confidence: 68%

Section: Thermodynamics Of Vaporizationmentioning

confidence: 99%

See 1 more Smart Citation

Phase-transition Perfluorocarbon Nanoparticles for Ultrasound Molecular Imaging and Therapy

Xu¹,

Cao²,

Xu³

et al. 2015

Nano BioMed ENG

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“…This introductory chapter is devoted broadly to the topic of theranostics and the role of functional nanometer-sized agents in personalized medicine [1,50,59,[67][68][69][70][71][72][73][74]. Over the past 2 decades, the field has gained a tremendous boost with high impending for translation.…”

Section: Resultsmentioning

confidence: 99%

Multimodal Imaging and Theranostic Application of Disease-Directed Agents

Caffarini

Kelleher

Konopka

et al. 2015

Topics in Medicinal Chemistry

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Contrast agents have long helped researchers and physicians alike delineate boundaries, but new diagnostic information is always sought after. A new field of molecularly targeted CT agents hopes to fill this void and supply physicians with prognostic information to find better treatments for patients. Borrowing from drug delivery and design, nanoparticles and similar platforms are being explored to help visualize complex biologic processes with never before seen resolution and fidelity. We discuss the development of this field and feasibility of translating some of these prospects to the clinic. Advances in chemistry, molecular biology, and engineering have molded this field emphasizing the early detection and treatment of diseases at the molecular and cellular level. Myriads of nanomedicine platforms have been proposed and developed and tested in laboratories and in preclinical models. However, very few have been translated to clinical trials. It is therefore a critical issue to recognize the factors affecting their eventual application in human. Better understanding of biological and biophysical obstacles encountered by these agents is necessary. Toward this aim, we critically review our present understanding of the biological obstacles encountered by the nano-agents, which we hope will motivate more studies to tune these technologies for future translational and clinical applications.

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“…As PDUS is dependent on density and size of the imaged particles, the signal detected reflected the size increase of the NBs associated with the vaporization of the perfluoropentane core, due to ADV phenomenon. ADV is a physical process in which the pressure waves of US induce a phase transition that cause liquid nanodroplets to form gas bubbles [41]. Furthermore, the nanodroplets to nanobubble conversion was also observed by optical microscopy analysis.…”

Section: Page 14 Of 27mentioning

confidence: 97%

Preparation and in vitro characterization of chitosan nanobubbles as theranostic agents

Cavalli

Argenziano

Vigna

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Please cite this article as: R. Cavalli, M. Argenziano, E. Vigna, P. Giustetto, E. Torres, S. Aime, E. Terreno, Preparation and in vitro characterization of chitosan nanobubbles as theranostic agents, Colloids and Surfaces B: Biointerfaces (2015), http://dx.doi.org/10. 1016/j.colsurfb.2015.03.023 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 27 A c c e p t e d M a n u s c r i p A c c e p t e d M a n u s c r i p t 2 ABSTRACT Theranostic delivery systems are nanostructures that combine the modality of therapy and diagnostic imaging. Polymeric micro-and nanobubbles, spherical vesicles containing a gas core, have been proposed as new theranostic carriers for MRI-guided therapy. In this study, chitosan nanobubbles were purposely tuned for the co-delivery of prednisolone phosphate and a Gd (III) complex, as therapeutic and MRI diagnostic agent, respectively. Perfluoropentane was used for filling up the internal core of the formulation. These theranostic nanobubbles showed diameters of about 500 nm and a positive surface charge that allows the interaction with the negatively charged Gd-DOTP complex. Pluronic F68 was added to the nanobubble aqueous suspension as stabilizer agent. The encapsulation efficiency was good for both the active compounds, and a prolonged drug release profile was observed in vitro. The effect of ultrasound stimulation on prednisolone phosphate release was evaluated at 37 °C. A marked increase on drug release kinetics with no burst effect was obtained after the exposure of the system to ultrasound. Furthermore, the relaxivity of the MRI probe changed upon incorporation in the nanobubble shell, thereby offering interesting opportunity in dual MRI-US experiments. The ultrasound characterization showed a good in vitro echogenicity of the theranostic nanobubbles.In summary, chitosan drug-loaded nanobubbles with Gd (III) complex bound to their shell might be considered a new platform for imaging and drug delivery with the potential of improving anticancer treatments.

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Acoustic Droplet Vaporization in Biology and Medicine

Cited by 79 publications

References 85 publications

Phase-transition Perfluorocarbon Nanoparticles for Ultrasound Molecular Imaging and Therapy

Phase-transition Perfluorocarbon Nanoparticles for Ultrasound Molecular Imaging and Therapy

Multimodal Imaging and Theranostic Application of Disease-Directed Agents

Preparation and in vitro characterization of chitosan nanobubbles as theranostic agents

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