Acoustic cavitation-induced shear: a mini-review

Mondal, Joydip; Lakkaraju, Rajaram; Ghosh, Parthasarathi; Ashokkumar, Muthupandian

doi:10.1007/s12551-021-00896-5

Cited by 12 publications

(3 citation statements)

References 89 publications

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“…Significant effort has been focused on improving drug delivery and distribution to benefit pancreatic cancer patients [ 60 , 61 , 62 , 63 , 64 , 65 , 66 ]. We described successful use of focused ultrasound, coupled with co-administered cavitation nuclei consisting of gas stabilizing SonoTran Particles, to improve the in situ deposition of clinically relevant drugs for pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Improved Therapeutic Delivery Targeting Clinically Relevant Orthotopic Human Pancreatic Tumors Engrafted in Immunocompromised Pigs Using Ultrasound-Induced Cavitation: A Pilot Study

Imran,

Tintera,

Morrison

et al. 2023

Pharmaceutics

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Pancreatic tumors can be resistant to drug penetration due to high interstitial fluid pressure, dense stroma, and disarrayed vasculature. Ultrasound-induced cavitation is an emerging technology that may overcome many of these limitations. Low-intensity ultrasound, coupled with co-administered cavitation nuclei consisting of gas-stabilizing sub-micron scale SonoTran Particles, is effective at increasing therapeutic antibody delivery to xenograft flank tumors in mouse models. Here, we sought to evaluate the effectiveness of this approach in situ using a large animal model that mimics human pancreatic cancer patients. Immunocompromised pigs were surgically engrafted with human Panc-1 pancreatic ductal adenocarcinoma (PDAC) tumors in targeted regions of the pancreas. These tumors were found to recapitulate many features of human PDAC tumors. Animals were intravenously injected with the common cancer therapeutics Cetuximab, gemcitabine, and paclitaxel, followed by infusion with SonoTran Particles. Select tumors in each animal were targeted with focused ultrasound to induce cavitation. Cavitation increased the intra-tumor concentrations of Cetuximab, gemcitabine, and paclitaxel by 477%, 148%, and 193%, respectively, compared to tumors that were not targeted with ultrasound in the same animals. Together, these data show that ultrasound-mediated cavitation, when delivered in combination with gas-entrapping particles, improves therapeutic delivery in pancreatic tumors under clinically relevant conditions.

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Section: Discussionmentioning

confidence: 99%

Improved Therapeutic Delivery Targeting Clinically Relevant Orthotopic Human Pancreatic Tumors Engrafted in Immunocompromised Pigs Using Ultrasound-Induced Cavitation: A Pilot Study

Imran,

Tintera,

Morrison

et al. 2023

Pharmaceutics

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“…A feature of the behavior of cavitation bubbles is the possibility of the appearance of damped oscillations, in terms of their size, preceding the collapse of the bubble, and the presence of these oscillations, frequency, amplitude, and degree of attenuation depend on operating parameters: the initial radius of the bubble, steam temperature, water temperature, and pressure of steam and water [64][65][66]. It has been established that heat transfer and the kinetics of phase transitions in the stage of maximum compression determine the nature of the oscillations [66].…”

Section: Dynamics Of a Steam Bubble In Hydrodynamic Cavitation Processesmentioning

confidence: 99%

Numerical Modeling of the Behavior of Bubble Clusters in Cavitation Processes

Pavlenko

2024

Energies

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To study the behavior of a bubble clusters in cavitation devices, a numerical study of the dynamics of bubbles in a compressible liquid was performed, taking into account interfacial heat and mass transfer. The influence of regime and system parameters on the intensity of cavitation processes is considered. Physical and chemical transformations during the cavitation treatment of liquids are caused not only by the action of shock waves and emitted pressure pulses but also by extreme thermal effects. At the stage of extreme compression of the bubble, the vapor inside the bubble and the liquid in its vicinity transform into the state of a supercritical fluid. The presented model analyzes the nature of microflows in the interbubble space and carries out a quantitative calculation of the local values of the parameters of the velocity and pressure fields.

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“…This process is largely based on the phenomenon of acoustic cavitation, which is defined as the growth and collapse of pre-existing microbubbles under the influence of an ultrasonic field in liquids. The formation of bubbles is due to the strong decline in local instantaneous pressure induced by strong ultrasound or by some hydrodynamic motion ( Mondal et al, 2021 ; Liu et al, 2023 ). Under optimum conditions, the bubbles are likely to collapse very violently due to their inherent spherical geometry and the inertia of the surrounding liquid.…”

Section: Sonophotocatalysis Mechanismmentioning

confidence: 99%

Advances on sonophotocatalysis as a water and wastewater treatment technique: efficiency, challenges and process optimisation

Mapukata,

Ntsendwana,

Mokhena

et al. 2023

Front. Chem.

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Due to water shortage and increased water pollution, various methods are being explored to improve water quality by treating contaminants. Sonophotocatalysis is a combination of two individual water treatment processes i.e., photocatalysis and sonocatalysis. With advantages including shorter reaction times and enhanced activity, this technique shows possible futuristic applications as an efficient water treatment technology. Herein, background insight on sonophotocalysis as a water and wastewater treatment technique as well as the general mechanism of activity is explained. The commonly used catalysts for sonophotocatalytic applications as well as their synthesis pathways are also briefly discussed. Additionally, the utilisation of sonophotocatalysis for the disinfection of various microbial species as well as treatment of wastewater pollutants including organic (dyes, pharmaceuticals and pesticides) and inorganic species (heavy metals) is deliberated. This review also gives a critical analysis of the efficiency, enhancement strategies as well as challenges and outlooks in this field. It is thus intended to give insight to researchers in the context of facilitating future developments in the field of water treatment, and advancing sonophotocatalysis towards large-scale implementation and commercialization.

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Acoustic cavitation-induced shear: a mini-review

Cited by 12 publications

References 89 publications

Improved Therapeutic Delivery Targeting Clinically Relevant Orthotopic Human Pancreatic Tumors Engrafted in Immunocompromised Pigs Using Ultrasound-Induced Cavitation: A Pilot Study

Improved Therapeutic Delivery Targeting Clinically Relevant Orthotopic Human Pancreatic Tumors Engrafted in Immunocompromised Pigs Using Ultrasound-Induced Cavitation: A Pilot Study

Numerical Modeling of the Behavior of Bubble Clusters in Cavitation Processes

Advances on sonophotocatalysis as a water and wastewater treatment technique: efficiency, challenges and process optimisation

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