Acoustic biomarker of placental pathophysiology and adverse fetal outcome

Riknagel, Diana; Humaidan, P.; Farlie, Richard; Zimmermann, H.; Ramsing, Mette; Struijk, Johannes

doi:10.1016/j.placenta.2015.07.204

Cited by 3 publications

(5 citation statements)

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“…Consensus is stated by Khong et al [14], that high velocity maternal malperfusion of the placenta manifesting in FGR may both cause damage to placentation and later function, and that earlier concepts and definition of maternal vascular underperfusion should be changed to maternal vascular malperfusion. It is also pointed out that a multidisciplinary approach of investigating placental function could be a way forward [28]. The present study confirms that biosensors indeed could contribute to a way forward.…”

Section: Discussionsupporting

confidence: 82%

“…In addition, a positive trend was seen towards significant associations between the MAT test and systolic BP (Table 3). These findings imply that hypertension or preeclampsia, that share the same phenotypic pathway of placental dysfunction as FGR [12,14], could also be related to MAT as indicated in earlier case studies [28]. Consensus is stated by Khong et al [14], that high velocity maternal malperfusion of the placenta manifesting in FGR may both cause damage to placentation and later function, and that earlier concepts and definition of maternal vascular underperfusion should be changed to maternal vascular malperfusion.…”

Section: Discussionmentioning

confidence: 87%

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Biosensor for Detecting Fetal Growth Restriction in a Low-Resource Setting

Jacobsen¹,

Schmiegelow

Sørensen

et al. 2021

Reprod. Med.

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One strategy for improving detection of fetal growth restriction (FGR) is developing biosensors identifying placental dysfunction as a leading pathogenesis for FGR. The aim of this pilot study was to investigate the performance of a biosensor specified to detect placental dysfunction by means of maternal arterial turbulence acoustics in a low-resource setting. A cohort of 147 singleton pregnant women were prospectively followed with double-blinded biosensor tests, sonographic estimation of fetal weight (EFW) and Doppler flow at 26–28, 32–34 and 37–39 weeks of pregnancy. Full term live births with recorded birth weights (BWs) and without major congenital malformations were included. Outcomes were defined as (A) a solitary biometric measure (BW < 3rd centile) and as (B) a biometric measure and contributory functional measure (BW < 10th centile and antenatally detected umbilical artery pulsatility index > 95th centile). Data from 118 women and 262 antenatal examinations were included. Mean length of pregnancy was 40 weeks (SD ± 8 days), mean BW was 3008 g (SD ± 410 g). Outcome (A) was identified in seven (6%) pregnancies, whereas outcome (B) was identified in one (0.8%) pregnancy. The biosensor tested positive in five (4%) pregnancies. The predictive performance for outcome (A) was sensitivity = 0.29, specificity = 0.97, p = 0.02, positive predictive value (PPV) was 0.40 and negative predictive value (NPV) was 0.96. The predictive performance was higher for outcome (B) with sensitivity = 1.00, specificity = 0.97, p = 0.04, PPV = 0.20 and NPV = 1.00. Conclusively, these pilot-study results show future potential for biosensors as screening modality for FGR in a low-resource setting.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 87%

Biosensor for Detecting Fetal Growth Restriction in a Low-Resource Setting

Jacobsen¹,

Schmiegelow

Sørensen

et al. 2021

Reprod. Med.

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“…The most commonly studied organs were, and still are, the lungs and the heart, with doctors long using sounds to diagnose disease in the cardiovascular and respiratory systems [2,3,4]. Sounds have more recently been exploited as biomarkers in fields as diverse as joint ageing and degeneration [5], and placental pathophysiology [6].…”

Section: Introductionmentioning

confidence: 99%

Bowel Sounds Identification and Migrating Motor Complex Detection with Low-Cost Piezoelectric Acoustic Sensing Device

Allwood

Webberley

et al. 2018

Sensors

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Interpretation of bowel sounds (BS) provides a convenient and non-invasive technique to aid in the diagnosis of gastrointestinal (GI) conditions. However, the approach’s potential is limited by variation between BS and their irregular occurrence. A short, manual auscultation is sufficient to aid in diagnosis of only a few conditions. A longer recording has the potential to unlock additional understanding of GI physiology and clinical utility. In this paper, a low-cost and straightforward piezoelectric acoustic sensing device was designed and used for long BS recordings. The migrating motor complex (MMC) cycle was detected using this device and the sound index as the biomarker for MMC phases. This cycle of recurring motility is typically measured using expensive and invasive equipment. We also used our recordings to develop an improved categorization system for BS. Five different types of BS were extracted: the single burst, multiple bursts, continuous random sound, harmonic sound, and their combination. Their acoustic characteristics and distribution are described. The quantities of different BS during two-hour recordings varied considerably from person to person, while the proportions of different types were consistent. The sensing devices provide a useful tool for MMC detection and study of GI physiology and function.

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“…The maternal vascular murmur (MVM) is a new acoustic marker of disturbed maternal vascular flow that is currently being investigated in the prenatal clinical context. The hypothesis of the present study was that MVM could be used to identify fetuses compromised by placental dysfunction attributable to abnormal spiral artery modification.…”

Section: Introductionmentioning

confidence: 99%

“…5,6 The ability to distinguish a healthy fetus with a normal or low weight from a compromised fetus is not only critical in the clinical context, but is also important as a source of preclinical information: in the long term, the fetal response to placental dysfunction is associated with comorbidities such as cardiovascular and metabolic diseases. 7,8 The maternal vascular murmur (MVM) is a new acoustic marker of disturbed maternal vascular flow [9][10][11] that is currently being investigated in the prenatal clinical context. The hypothesis of the present study was that MVM could be used to identify fetuses compromised by placental dysfunction attributable to abnormal spiral artery modification.…”

Section: Introductionmentioning

confidence: 99%