Acoustic and Elastic Properties of Glycerol in Oil-Based Gel Phantoms

Cabrelli, Luciana C.; Grillo, Felipe Fardin; Sampaio, Diego R. T.; Carneiro, Adriana Munhoz; Pavan, Theo Z.

doi:10.1016/j.ultrasmedbio.2017.05.010

Cited by 40 publications

(31 citation statements)

References 33 publications

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“…In particular, lower LDPE concentrations may be preferred for high frequency photoacoustic imaging systems and these can be easily fabricated by decreasing the polymer concentration, as shown for similar SEBS-based material recipes [44], [46]. Higher speed of sound values required for mimicking tissues, such as muscle or kidney (>1520 m•s -1 ; Supplementary Table 1), could be achieved by choosing a plasticizer with higher viscosity [46] or by adding compounds such as glycerol [73], but these would lead respectively to higher acoustic attenuation [46] or acoustic backscattering [73], and reduced ease of the phantom fabrication. For independent tuning of acoustic backscattering properties, glass microspheres could be tested in future [40].…”

Section: Discussionmentioning

confidence: 99%

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A Copolymer-in-Oil Tissue-Mimicking Material With Tuneable Acoustic and Optical Characteristics for Photoacoustic Imaging Phantoms

Hacker

Joseph

Ivory

et al. 2021

IEEE Trans. Med. Imaging

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Photoacoustic imaging (PAI) standardisation demands a stable, highly reproducible physical phantom to enable routine quality control and robust performance evaluation. To address this need, we have optimised a lowcost copolymer-in-oil tissue-mimicking material formulation. The base material consists of mineral oil, copolymer and stabiliser with defined Chemical Abstract Service numbers. Speed of sound c(f) and acoustic attenuation coefficient α(f) were characterised over 2-10 MHz; optical absorption µa(ʎ) and reduced scattering µs'(ʎ) coefficients over 450-900 nm. Acoustic properties were optimised by modifying base component ratios and optical properties were adjusted using additives. The temporal, thermomechanical-and photo-stability were studied, along with intra-laboratory fabrication and field-testing. c(f) could be tuned up to (1516±0.6)m•s -1 and α(f) to (17.4±0.3)dB•cm -1 at 5MHz. The base material exhibited negligible µa(ʎ) and µs'(ʎ), which could be independently tuned by addition of Nigrosin or TiO2 respectively. These properties were stable over almost a year and were minimally affected by recasting. The material showed high intra-laboratory reproducibility (coefficient of variation <4% for c(f), α(f), optical transmittance and reflectance), and good photoand mechanical-stability in the relevant working range. The optimised copolymer-in-oil material represents an excellent candidate for widespread application in PAI phantoms, with properties suitable for broader use in biophotonics and ultrasound imaging standardisation efforts.

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Section: Discussionmentioning

confidence: 99%

“…Our material was found to be photostable under the tested conditions and mechanically stable in the relevant working range of 20 to 40°C. It is known that the mechanical properties of copolymer-in-oil materials can be tuned in the tissue-mimicking range by adjusting the polymer concentration [46], [73]. The choice of plasticizer (e.g.…”

Section: Discussionmentioning

confidence: 99%

A Copolymer-in-Oil Tissue-Mimicking Material With Tuneable Acoustic and Optical Characteristics for Photoacoustic Imaging Phantoms

Hacker

Joseph

Ivory

et al. 2021

IEEE Trans. Med. Imaging

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“…Ultrasound phantoms that mimic the ultrasound velocity, attenuation coefficient, and texture of human soft tissues are commonly used for teaching medical students about the operation and performance of diagnostic ultrasound equipment. [1][2][3][4][5][6][7][8][9][10][11][12] For example, they have been used to teach students how to maneuver ultrasound-guided needles and conduct blind catheter insertions. [13][14][15][16][17][18] Commercially available ultrasound phantoms with guaranteed properties and quality are often fixed with polyurethane or oil gel, polyvinyl alcohol (PVA), polyvinyl chloride plastic (PVC-P), or styrene-ethylene-butylene-styrene (SEBE), whereas handmade phantoms, which are relatively low-cost and easy to make, are fixed using gelatin or agar as the gelling agent.…”

Section: Introductionmentioning

confidence: 99%

Sodium Alginate Ultrasound Phantom for Medical Education

Aoyagi

2021

Ultrason Imaging

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The ultrasound phantoms used to educate medical students should not only closely mimic the ultrasound characteristics of human soft tissues but also be inexpensive and easy to manufacture. I have been studying handmade ultrasound phantoms and proposed an ultrasound phantom comprising calcium alginate hydrogel that met these requirements but caused a speckle pattern similar to that observed in ultrasound images of liver. In this study, I show that adding ethanol to the precursors used to fabricate the phantom reduces the speckle pattern. The ultrasound propagation velocity and attenuation coefficient of the phantom were 1561 ± 8 m/s and 0.54 ± 0.18 dB/cm/MHz, respectively (mean ± standard deviation), which are within the ranges of those in human soft tissues (1530-1600 m/s and 0.3-1.0 dB/cm/MHz, respectively). This phantom is easy to fabricate without special equipment, is inexpensive, and is suitable for elementary training on ultrasound diagnosis, operation of ultrasound-guided needles, and blind catheter insertion.

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“…phantoms. This difference can be explained because phantoms manufactured at the gelatin concentration [187,188] used here are considerably softer than the SEBS gels manufactured in the present study [183]. As stated before, according to equation (3.5), the oscillation frequency of the nanoparticles due to produced magnetomotive force is twice that of the applied magnetic field.…”

Section: Resultsmentioning

confidence: 61%

“…This glycerol/nanoparticles mixture was added to the gel at 85 ˚C in a fraction of 15% of the oil mass. This procedure [183,184] ensures that these nanoparticles are located in homogeneously dispersed glycerol droplets formed in the phantoms. The reader is referred to the ref [183,184] for details about the preparation of glycerol in oil-based phantoms as well as the acoustic and elastic properties of the materials.…”

Section: Phantom Preparationmentioning

confidence: 99%

Nanopartículas de magnetita dopadas com zinco para fins teranósticos: magnetoacustografia e hipertermia magnética

Hadadian¹

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Acoustic and Elastic Properties of Glycerol in Oil-Based Gel Phantoms

Cited by 40 publications

References 33 publications

A Copolymer-in-Oil Tissue-Mimicking Material With Tuneable Acoustic and Optical Characteristics for Photoacoustic Imaging Phantoms

A Copolymer-in-Oil Tissue-Mimicking Material With Tuneable Acoustic and Optical Characteristics for Photoacoustic Imaging Phantoms

Sodium Alginate Ultrasound Phantom for Medical Education

Nanopartículas de magnetita dopadas com zinco para fins teranósticos: magnetoacustografia e hipertermia magnética

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