Acorus gramineus inhibits microglia mediated neuroinflammation and prevents neurotoxicity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease

α-Asarone attenuates microglia-mediated neuroinflammation by inhibiting NF kappa B activation and mitigates MPTP-induced behavioral deficits in a mouse model of Parkinson's disease

“…It is an active constituent of Acorus gramineus Solander rhizome (AGR) used to treat senile dementia (Lin et al, 2012;Ma et al, 2015) and was claimed traditionally in East Asian countries to possess sedative, digestive, analgesic, diuretic and antifungal activities. Apart from its traditional claims, scientific reports showed that AGR can be used as neuroprotective (Jiang et al, 2012;Limon et al, 2009;Manikandan and Devi, , anticonvulsant (Pages et al, 2010) and hyperlipidemic agent (Garduno et al, 1997). Recent evidence showed that a-asarone ameliorated memory deficits in LPS-treated mice via its antiinflammatory actions (Shin et al, 2014).…”

Aqueous Extract of Dendropanax morbiferus Leaves Effectively Alleviated Neuroinflammation and Behavioral Impediments in MPTP‐Induced Parkinson’s Mouse Model

“…The resting microglia can be evoked by various inflammatory insults, such as LPS/MPTP-induced toxicity, which in turn leads to an upsurge in proinflammatory cytokines (TNF- α , IL-1 β , and IL-6) and inflammatory mediators (COX-2 and inducible nitric oxide synthase (iNOS)), generating a ROS/RNS environment [ 14 , 36 , 37 ]. Jiang et al described the antineuroinflammatory role of Acorus gramineus leaf aqueous extract by elucidating its potential modulating role on inflammatory mediators in MPTP-induced mouse model of Parkinson's disease [ 38 ]. A recent study reported that the aqueous extract of Withania somnifera leaves effectively suppressed the LPS-induced microglial inflammatory action by modulating the reported inflammatory mediators [ 39 ].…”

Compound Dihuang Granule Attenuates the Da Neuron Loss and Motor Deficits in 6-OHDA  Induced Parkinson’s Disease Rats

“…Unilateral injection of 6-OHDA was performed to set up a rat model of PD, which is the most common and widely used model to explore the e cacy of PD drugs. The protective effects and molecular mechanisms of the sulfated polysaccharide (SJP) against 6-OHDA-induced toxicity were investigated in SH-SY5Y cells [21]. Wang used 6-OHDA induced PD rats to analyze the effect of electroacupuncture on alleviating motor symptoms and up-regulating vesicular glutamatergic transporter 1 expression [32].…”

“…The paeoni orin and paeonol derived from Paeoniae radix alba had neuroprotective effects in an in vitro model of PD [20]. Acorus gramineus extract exerted antineuroin ammatory effects against activated microglia mediated insults through multiple signaling pathways and prevented in vivo neuronal cell death in mouse model of PD [21]. Tanshinone I treatment signi cantly attenuated 6-OHDA-induced striatal oxidative stress and ameliorated dopaminergic neurotoxicity in 6-OHDA-lesioned mice [22].…”