Acorenone B: AChE and BChE Inhibitor as a Major Compound of the Essential Oil Distilled from the Ecuadorian Species Niphogeton dissecta (Benth.) J.F. Macbr

Calva, James; Bec, Nicole; Gilardoni, Gianluca; Larroque, Christian; Cartuche, Luis; Bicchi, Carlo; Montesinos, José Vinicio

doi:10.3390/ph10040084

Cited by 32 publications

(34 citation statements)

References 40 publications

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“…Ionization mode: impact of electrons (70 eV). e extract was diluted to 1 :100 v/v in dichloromethane (Fisher Scientific, 99.9% pure) and 1 µL of the solution was injected [14].…”

Section: Phytochemical Analysis Of Ethanol Of Extract Cordia Luteamentioning

confidence: 99%

Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats

Rojas-Armas

Arroyo-Acevedo

Ortiz-Sánchez

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The objective of this study was to evaluate the chemopreventive effect of the ethanolic extract of Cordia lutea flowers (EECL) on N-methyl-N-nitrosourea- (MNU), cyproterone-, and testosterone-induced prostate cancer in rats. 40 Holtzman male rats were used and assigned to 5 groups (n = 8). In Group I, rats received normal saline (10 mL/Kg); Group II: rats were induced for prostate cancer with cyproterone, testosterone, and NMU; Groups III, IV, and V: rats received EECL daily, at doses of 50, 250, and 500 mg/kg body weight, respectively. After the period of treatment, animals were sacrificed by an overdose of pentobarbital and blood samples were collected for determination of prostate-specific antigen (PSA). The prostate was dissected and weighed accurately. The ventral lobe of the prostate was processed for histopathology analysis. The somatic prostate index decreased with EECL at dependent dose, from 0.34 ± 0.04 to 0.23 ± 0.05 (P<0.05). The PSA levels also decreased significantly at doses of 250 and 500 mg/kg. Histopathological analysis showed a decrease in the number of prostatic layers with high-grade prostatic intraepithelial neoplasia (HG-PIN) and low-grade prostatic intraepithelial neoplasia (LG-PIN) at the dose of 500 mg/kg. The ethanolic extract of Cordia lutea flowers had a chemopreventive effect on induced prostate cancer in rats.

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“…Ionization mode: impact of electrons (70 eV). e extract was diluted to 1 :100 v/v in dichloromethane (Fisher Scientific, 99.9% pure) and 1 µL of the solution was injected [14].…”

Section: Phytochemical Analysis Of Ethanol Of Extract Cordia Luteamentioning

confidence: 99%

Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats

Rojas-Armas

Arroyo-Acevedo

Ortiz-Sánchez

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Among the natural products the authors are interested in, we can cite essential oils (EOs) [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. According to the European Pharmacopeia, an EO is an “odorous product, usually of complex composition, obtained from a botanically defined plant raw material by steam distillation, dry distillation, or a suitable mechanical process without heating.…”

Section: Introductionmentioning

confidence: 99%

Chemical and Enantioselective Analysis of the Leaf Essential Oil from Piper coruscans Kunth (Piperaceae), a Costal and Amazonian Native Species of Ecuador

Gilardoni

Matute

Ramírez

2020

Plants

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In the present study, an essential oil was distilled from the leaves of Piper coruscans Kunth, a native Amazonian species belonging to the family Piperaceae and quite common in Ecuador. The chemical analysis was performed by GC-MS (qualitative) and GC-FID (quantitative), on polar and non-polar columns, detecting a total of 58 compounds of which 52 were identified. All the identified compounds were quantified. The essential oil was mainly constituted of sesquiterpenes (54.1–55.0%) and oxygenated sesquiterpenoids (32.5–33.6%), the major constituents being: (E)-β-caryophyllene (24.1–25.0%), α-humulene (11.6–12.0%), caryophyllene oxide (9.3–10.9%), linalool (4.5–5.2%), humulene epoxide II (3.6–4.1%), (E)-nerolidol (3.7–4.0%), α-copaene (3.7–3.9%), α-muurolol (3.4–3.7%), α-selinene (3.4–3.5%), β-selinene (3.1–3.3%), and one undetermined oxygenated sesquiterpenoid (3.1–3.3%). The aqueous phase (hydrolate) of the distillation process was also submitted to chemical analysis, showing linalool as the main organic compound in solution, with a concentration of 12.3–15.7 mg/100 mL. The essential oil was than analyzed for the enantiomeric distribution of its monoterpene constituents, affording the following enantiomeric excesses in two β-cyclodextrin-based enantioselective columns: (1S,5S)-(-)-α-pinene (60.0–69.6%), (1S,5S)-(-)-β-pinene (5.2–7.2%), (R)-(-)-α-phellandrene (72.5–78.2%), (R)-(+)-limonene (28.6%) and (R)-(-)-linalool (1.8–3.1%).

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“…In the tropical species Niphogeton dissecta, it was the major oil compound and the essential oil had some antibutylcholinesterase activity. [27] β-Elemene was in the present oils a minor compound accounting in most samples for less than 4 % of the oil and reaching a maximum of 12.2 % in the leaf essential oil from KO2. In contrast, a flower essential oil from Serbia had with 40.4 % β-elemene as main compound.…”

Section: Resultsmentioning

confidence: 67%

Chemodiversity of Essential Oils in Seseli libanotis (L.) W.D.J.Koch (Apiaceae) in Central Europe

Chizzola

2019

Chemistry & Biodiversity

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Seseli libanotis is an aromatic umbelliferous plant distributed sporadically on dry grassland edges in Europe and Western Asia. The essential oil composition in the different plant parts was studied from plants collected on nine sites in Austria and one site in Alto Adige, Italy. Monoterpenes such as α‐pinene, sabinene and β‐myrcene and the sesquiterpene germacrene D were present in all essential oils from the aerial parts. Inflorescences and fruits had the highest essential oil contents. These essential oils from four sites were rich in acorenone B, while from other three sites they had carotol as a major component. Osthole as furocoumarin occurred in some oils. The root essential oils were dominated by α‐pinene. The essential oil variability has been studied by principal component analysis (PCA) and discriminant analysis (DA) with plant parts or sampling site as a priori groups. PCA could well separate inflorescence and fruit essential oil samples from leaf and stem essential oil samples. DA differentiated well between the plant parts and most of the sampling sites.

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Acorenone B: AChE and BChE Inhibitor as a Major Compound of the Essential Oil Distilled from the Ecuadorian Species Niphogeton dissecta (Benth.) J.F. Macbr

Cited by 32 publications

References 40 publications

Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats

Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats

Chemical and Enantioselective Analysis of the Leaf Essential Oil from Piper coruscans Kunth (Piperaceae), a Costal and Amazonian Native Species of Ecuador

Chemodiversity of Essential Oils in Seseli libanotis (L.) W.D.J.Koch (Apiaceae) in Central Europe

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