Acompanhamento farmacoterapêutico dos pacientes com leucemia mieloide crônica em uso de mesilato de imatinibe na Universidade Federal do Ceará

Aquino, Sterfen S.; Gonçalves, Raquel; Silva, Lilianne B.

doi:10.1590/s1516-84842009005000048

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…Segundo Baccarani et al (2013), o fator prognóstico mais importante é a resposta ao tratamento com inibidores de tirosina cinase (ITCs), que pode ser classificada em Ótima, Alerta e Falha e verificadas em períodos de três meses, seis meses, doze meses e qualquer tempo. A avaliação das respostas permitem monitorar a doença, favorecendo mudanças na terapia se houver necessidade, uma vez que as reações (AQUINO et al, 2009) e seu principal objetivo é a resposta citogenética completa, pois está relacionada à maior sobrevida (LAVALLADE et al, 2008). Existe correlação entre níveis plasmáticos baixos de MI e falha em alcançar resposta citogenética (PICARD et al, 2007).…”

Section: Introductionunclassified

Expressão do gene ABCA7 como indicador de adesão terapêutica ao Mesilato de Imatinib em pacientes com Leucemia Mieloide Crônica / Expression of the ABCA7 gene as adherence indicator to Imatinib Mesylate in patients with Chronic Myeloid Leukemia

Silva

Moreira-Nunes

Lemos

2021

BJHR

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Adherence to treatment with Imatinib Mesylate (IM), a frontline medication for Chronic Myeloid Leukemia (CML), is essential to guarantee a lasting, long-term response to the medication. The ABCA7 gene presented different levels of expression in a study of the sequencing of the transcriptome in patients with CML. Given this, the expression of this gene in the peripheral blood cells of patients with CML was quantified with the objective of validating the gene as a molecular indicator of the adhesion of patients to treatment with IM. The expression of the ABCA7 gene was analyzed based on cycle threshold (CT) values measured using real time PCR. The statistical analysis was run in the BIOESTAT 5.0 program to compare gene expression between patients and controls, taking the response of the patients to the treatment into account. Response to the treatment was significantly different when comparing the ABCA7 in the CML-free control group with control patients (p < 0.001) and patients with an alert response (p = 0.0165). The ABCA7 gene may be associated with treatment adherence, and is thus a potential candidate for a molecular indicator of the adhesion of patients with CML to treatment with IM.

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Section: Introductionunclassified

Expressão do gene ABCA7 como indicador de adesão terapêutica ao Mesilato de Imatinib em pacientes com Leucemia Mieloide Crônica / Expression of the ABCA7 gene as adherence indicator to Imatinib Mesylate in patients with Chronic Myeloid Leukemia

Silva

Moreira-Nunes

Lemos

2021

BJHR

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Overexpression of miR‑574‑3p suppresses proliferation and induces apoptosis of chronic myeloid leukemia cells via targeting IL6/JAK/STAT3 pathway

Yang

Zhang

et al. 2018

Exp Ther Med

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The present study aimed to elucidate the potential roles and regulatory mechanism of microRNA (miR)-574-3p in the development of chronic myeloid leukemia (CML). The expression of miR-574-3p in peripheral blood obtained from patients with CML was examined. Subsequently, miR-574-3p was overexpressed and suppressed in CML K562 cells to further investigate the effects of miR-574-3p on cell proliferation, and apoptosis. Furthermore, a luciferase reporter assay was performed to investigate whether interleukin-6 (IL-6) was a target of miR-574-3p. In addition, the regulatory association between miR-574-3p and the IL-6/Janus kinase (JNK)/signal transducer and activator of transcription-3 (STAT3) signaling pathway was explored. The expression of miR-574-3p in the peripheral blood obtained from patients with CML was significantly lower compared with that in healthy controls. Overexpression of miR-574-3p significantly inhibited the proliferation and induced the apoptosis of K562 cells, whereas suppression of miR-574-3p exhibited opposite effects. In addition, IL-6 was identified to be a direct target of miR-574-3p. Overexpression of IL-6 significantly promoted the proliferation and inhibited the apoptosis of K562 cells. Furthermore, overexpression of miR-574-3p inhibited the activation of the JAK/STAT3 signaling pathway, which was rescued by overexpression of IL-6. The results of the current study indicate that miR-574-3p overexpression may serve an important role in inhibiting proliferation and inducing apoptosis of K562 cells via suppression of IL-6/JAK/STAT3 signaling pathway activation. miR-574-3p may serve as a potential therapeutic target for CML.

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A Importância Do Acompanhamento Farmacoterapêutico a Idosos Pertencentes Ao Grupo Da “Melhor Idade” Da Facesa

Sá

Fortes

2014

Saúde (Sta. Maria)

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The importance of the pharmacotherapeutic monitoring of elderly belonging to group of "best age" of FACESA ABSTRACTObjective -To investigate the importance of pharmacotherapeutic monitoring the elderly. Methods -Cross-sectional study conducted at the Faculty of Science and Education Sena Aires to Valparaiso de Goiás in September 2012. Sample of 30 elderly, both sexes, participants of the group "Golden Age". The questionnaire was adapted from the method Dáder Monitoring Pharmacotherapy, SF 36, socioeconomic and sociodemographic variables, lifestyle habits, health status, medication use and self-perceived quality of life. Results -It was observed that 56.7% (n = 17) of older people using drugs on their own, 63.3% (n = 19) were using potions or teas, 76.7% (n = 23) of polypharmacy and 10% (n = 3) were allergic to any medicine. No drug interaction was observed in 56.7% (n = 17) of cases and 13.3% (n = 4) had potential risk of drugs interations. Conclusion -The results indicate the need for a pharmacotherapeutic monitoring quality for the elderly in order to minimize potential risk of drugs interations between some medications.

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Acompanhamento farmacoterapêutico dos pacientes com leucemia mieloide crônica em uso de mesilato de imatinibe na Universidade Federal do Ceará

Cited by 3 publications

References 8 publications

Expressão do gene ABCA7 como indicador de adesão terapêutica ao Mesilato de Imatinib em pacientes com Leucemia Mieloide Crônica / Expression of the ABCA7 gene as adherence indicator to Imatinib Mesylate in patients with Chronic Myeloid Leukemia

Expressão do gene ABCA7 como indicador de adesão terapêutica ao Mesilato de Imatinib em pacientes com Leucemia Mieloide Crônica / Expression of the ABCA7 gene as adherence indicator to Imatinib Mesylate in patients with Chronic Myeloid Leukemia

Overexpression of miR‑574‑3p suppresses proliferation and induces apoptosis of chronic myeloid leukemia cells via targeting IL6/JAK/STAT3 pathway

A Importância Do Acompanhamento Farmacoterapêutico a Idosos Pertencentes Ao Grupo Da “Melhor Idade” Da Facesa

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