Acod1 mediates anti-inflammatory Treg function in sepsis
Michel Edwar Mickael,
Norwin Kubick,
Atanas G. Atansov
et al.
Abstract:Sepsis is a serious, potentially fatal disease caused by the body’s reaction to microbial invasions by bacteria, viruses, and fungi. Current research shows that the process of fighting sepsis passes through two phases. The first phase is a cytokine storm, and the second phase involves a cycle of pro-inflammatory and anti-inflammatory responses led by Regulatory CD4+ T-cells (CD4+ Tregs). Various immunomodulatory therapies have been proposed to break the cycle of pro- and anti-inflammatory reactions to sepsis. … Show more
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