Acneiform Rash Caused by an Unlikely Drug: Topiramate

Abstract

Topiramate is an antiepileptic drug that can also be used for migraine prophylaxis, weight control, and even for methamphetamine dependence; the dosage margin is wide, and the list of side effects is shorter than with other anticonvulsants. We present the case of a 35-year-old man with a disseminated rash of the trunk and extremities after treatment with 25 mg of topiramate daily as a prophylactic migraine treatment. This case report is useful, as this patient was not polymedicated and had a score of 7 on the Naranjo Adverse Drug Reaction Probability Scale. The patient was diagnosed as atypical DRESS syndrome and resolved satisfactorily with symptomatic treatment and topiramate withdrawal; slowly, the lesions regressed. He required no further drugs for the dermatologic condition.

Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy

“…2 b) [ 72 , 73 ]. While there is some published evidence, the significant positive correlation between TPM use and the LAEP subdomains of headaches, skin problems, and disturbed sleep in the present analysis was clinically unapparent [ 74 – 78 ]. Unsteadiness and memory problems have also been described with ZNS use [ 79 ], which is in line with the results of the LAEP subdomain analysis (Fig.…”