Acneiform eruption caused by amineptine. A case report and review of the literature

Aranda, María Victoria de Gálvez; Sánchez-Sánchez, Purificación; Corral, MJ Alonso; García, RJ Bosch; Gallardo, M. A.; Ceballos, Enrique Herrera

doi:10.1046/j.1468-3083.2001.00281.x

Cited by 5 publications

(4 citation statements)

References 4 publications

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“…Indeed, they were predominantly women, mainly aged >40 years, with a severe psychiatric background (depression, schizophrenia, etc.). [23,34] They all disclosed a strikingly abrupt onset of monomorphic lesions composed of microcysts, macrocysts, and comedones of varying size. Inflammatory lesions were usually absent.…”

Section: Amineptinementioning

confidence: 99%

“…[22][23][24][25][26] Since then, over 30 cases have been reported. [27][28][29][30][31][32][33][34] Amineptine is a non-halogenated tricyclic antidepressant that was widely used before its withdrawal in January 1999 because of the high level of severe adverse events in France. Patients with amineptine-induced acne presented with some characteristic features.…”

Section: Amineptinementioning

confidence: 99%

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Drug-Induced Acneiform Eruption

Du‐Thanh

Kluger

Bensalleh

et al. 2011

American Journal of Clinical Dermatology

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Drug-induced acne is a specific subset of acne that usually has some specific features, namely a monomorphic pattern, an unusual location of the lesions beyond the seborrheic areas, an unusual age of onset, a resistance to conventional acne therapy and, of course, the notion of a recent drug introduction. Many drugs can be responsible for such a clinical pattern. Corticosteroids, neuropsychotherapeutic drugs, antituberculosis drugs, and immunomodulating molecules are the more classical drugs associated with induced acne. Recently, new drugs, mainly targeted therapy in the field of oncology, such as epidermal growth factor receptor inhibitors, have been associated with an increased frequency of this adverse effect. Disruption of the culprit drug is rarely mandatory in cases of drug-induced acne. Close cooperation between the dermatologist and medical staff in charge of the patient is an important challenge to achieve optimal management of the initial disease.

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Section: Amineptinementioning

confidence: 99%

Section: Amineptinementioning

confidence: 99%

Drug-Induced Acneiform Eruption

Du‐Thanh

Kluger

Bensalleh

et al. 2011

American Journal of Clinical Dermatology

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“…Severe acne and acneiform eruptions have been observed with high doses of tricyclic antidepressants like amineptine and lithium therapy [121][122][123][124]. In brain of mice, lithium significantly decreased the transcriptional activity and protein levels of FoxO3 [125], the most important activator of the FoxO1 promoter [126].…”

Section: Foxo1 Antidepressant-induced Acne and Isotretinoin-induced mentioning

confidence: 99%

Acneigenic Stimuli Converge in Phosphoinositol-3 Kinase/ Akt/Foxo1 Signal Transduction

Melnik¹

2010

J Clin Exp Dermatol

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“…Es un recurso dramático y literario, muy efectivo en cuanto a la comprensión intuitiva del proceso por parte del lector, pero claramente negativo e inapropiado al referirse a personas concretas con experiencias definidas. Desde cualquier punto de vista, es obvio lo inadecuado del término para la denominación de una enfermedad para la cual se pueden utilizar los términos 'erupción acneiforme por amineptina' [10] o 'acné iatrogénico macronodular' [11]. En este sentido, en el uso de 'monstruoso' ha prevalecido la consideración del impacto literario sobre el lector por encima de otras consideraciones éticas relativas al paciente (recurso estilístico denominado disfemismo).…”

Section: Comentariounclassified

La literatura como recurso didáctico complementario en la enseñanza y aprendizaje de la dermatología

2012

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Introduction. To classify literary texts from a medical perspective facilitates their application in the teaching and learning of medicine and dermatology. Materials and methods. Qualitative analysis of multiple literary texts and selection of those texts that contain references to a common skin disease (acne), which was selected as a paradigm. Results. A classification was carried out of the literary texts analyzed, based on five groups: autobiography of the skin disease; the writer describing skin disease in others; skin disease as a stylistic device in literature; the physician as writer: stylistic devices in the medical description of the disease; and medical texts related to selected literary texts. Conclusions. The literary texts, from a medical perspective, can be classified into five groups; this classification facilitates their implementation as a didactic resource in medical education and specialised dermatology teaching.

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Acneiform eruption caused by amineptine. A case report and review of the literature

Abstract: Acne caused by amineptine has always been described with typical characteristic clinical features, and the retentional and cutaneous lesions are dose related. We present a case of acne-like eruption due to amineptine in a woman under treatment for chronic depression.

Cited by 5 publications

References 4 publications

Drug-Induced Acneiform Eruption

Drug-Induced Acneiform Eruption

Acneigenic Stimuli Converge in Phosphoinositol-3 Kinase/ Akt/Foxo1 Signal Transduction

La literatura como recurso didáctico complementario en la enseñanza y aprendizaje de la dermatología

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