Acneform Changes in Areas of Cobalt Irradiation

Trunnell, Thomas N.; Baer, Rudolf L.; Michaelides, Paraskevas

doi:10.1001/archderm.1972.01620100059015

Cited by 18 publications

(4 citation statements)

References 5 publications

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“…[7], who described 2 patients with metastatic malignant disease treated with a sum of 5,700 and 3,900 rad through an anterior and posterior field of the trunk. 4 months later they developed an acneiform eruption with comedones, papules and pustules sharply confined to the areas of irradiation.…”

Section: Discussionmentioning

confidence: 99%

Comedo Formation Following Cobalt Irradiation

Larsen¹,

Heydenreich²,

Jv³

1979

Dermatology

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Section: Discussionmentioning

confidence: 99%

Comedo Formation Following Cobalt Irradiation

Larsen¹,

Heydenreich²,

Jv³

1979

Dermatology

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“…Sebase glandlar›n boyutlar›nda ve sebum sekresyonunda azalmaya neden olarak akne oluflumunu önledi¤i gösterilen yüzeyel X ›fl›n› tedavisinden k›sa bir süre sonra aknenin nüks etmesi, yeni tedavi ajanlar›n›n keflfi, radyoterapinin uzun dönem sekelleri ve malinite geliflim riskinin farkedilmesi, yirminci yüzy›l›n ortalar›ndan itibaren bu tedavi rejiminin kullan›m›n› s›n›rlam›flt›r 2,11 . Sonraki y›llarda malinite nedeni ile radyoterapi uygulanan hastalarda paradoks etki olarak irradyasyon bölgesinde akne ve komedon olufltu¤u rapor edilmifltir 1,2,10,[12][13][14][15][16][17][18] . Akneiform erüpsiyonlar, radyoterapinin oldukça nadir görülen geç komplikasyonudur ve ilk defa 1947 y›l›nda Bluefarb 17 taraf›ndan skuamöz hücreli kanser nedeni ile yüzeyel X ›fl›n› alan 63 yafl›ndaki bir hastada tan›mlanm›flt›r.…”

Section: Tart›flmaunclassified

A Case of Localized Acne Following Megavoltage Radiotherapy

Ceyhan¹,

Mullaaziz²,

Yıldırım³

et al. 2011

TURKDERM

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ÖzetAkut ve kronik radyodermatit, radyoterapinin oldukça s›k görülen ve iyi bilinen komplikasyonlar›d›r. Ancak irradyasyon bölgesine s›n›rl› akneiform lezyonlar, radyoterapinin oldukça nadir görülen geç komplikasyonudur. ‹rradyasyon sonras›nda oluflan aknenin etyopatogenezi henüz tam olarak bilinmemektedir. Lezyonlar, radyoterapi tamamland›ktan 2 hafta ile 6 ay aras›nda de¤iflen latent periyot sonras›nda oluflmaktad›r ve s›kl›kla bafl boyun bölgesinde yerleflim göstermektedir. Radyasyonun neden oldu¤u akneiform lezyonlar, yüzeyel X ›fl›n› tedavisi, derin kobalt tedavisi ve megavolaj tedavi gibi çok çeflitli radyoterapi tipleri ile oluflabilmektedir. Fakat literatürde tan›mlanan olgular›n ço¤unda, erupsiyonlar›n derin kobalt radyoterapi sonras›nda ortaya ç›kt›¤› rapor edilmifltir. Megavoltaj radyoterapinin neden oldu¤u akneiform lezyonlar ile ilgili oldukça az say›da rapor mevcuttur ve bilgilerimize göre, flimdiye kadar sadece 6 hasta tan›mlanm›flt›r. Bu makalede, evre III T hücreli lenfoblastik lenfoma nedeni ile profilaktik kranial megavoltaj radyoterapi uygulanan ve sonras›nda frontopariyetal bölgeye lokalize akne geliflen bir olgu sunulmufltur. (Türkderm 2011; 45: 53-5) Anahtar Kelimeler: Radyoterapi, megavoltaj, akne SummaryAcute and chronic radiodermatitis are well-recognized and relatively common complications of radiotherapy. However, acneiform lesions limited to the irradiation field are extremely rare and are late complication of radiation therapy. The etiopathogenesis of post-irradiation acne is not yet fully known. The lesions occur mainly in the head and neck region with a latent period of between 2 weeks and 6 months from the completion of therapy. Radiation-induced acneiform lesions can result from several types of radiotherapy, including superficial X-ray therapy, deep cobalt therapy and megavoltage therapy. However, in the majority of cases described in the literature, the eruptions have been reported to occur after deep cobalt radiotherapy. There are only a few reports concerning limited acneiform lesions caused by megavoltage therapy and to our knowledge, only six cases have been described to date. In this article, a case of localized acne on the frontoparietal area following prophylactic cranial megavoltage radiotherapy for stage III T-cell lymphoblastic lymphoma was reported. (Turkderm 2011; 45: 53-5)

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“…In addition, she had received a six months course of Testosterone. Despite employing the skin surface sparing advantages of cobalt therapy, Stein, Leyden andGoldschmidt (1972), Trunnell, Baer andMichaelides (1972) and Engels, Leavell and Maruyama (1974) have described seven patients with acneiform eruptions localised to areas of irradiation. In these reports the acne lesions developed one to six months after irradiation.…”

Section: Commentsmentioning

confidence: 99%