Acne vulgaris: new evidence in pathogenesis and future modalities of treatment

Hazarika, Neirita

doi:10.1080/09546634.2019.1654075

Cited by 92 publications

(77 citation statements)

References 42 publications

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“…Acne vulgaris is a common self‐limited skin disorder of the pilosebaceous units primarily in adolescents . It can be controlled by local, systemic, hormonal, or surgical therapies .…”

Section: Introductionmentioning

confidence: 99%

Randomized controlled double‐blind study of a cleanser composed of 5‐aminolevulinic acid and peptides on mild and moderate acne vulgaris

Lee

Kim

Park

et al. 2019

J of Cosmetic Dermatology

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Background Existing treatments of acne vulgaris may be complicated or elicit undesirable side effects. Therefore, new and safe therapeutic modalities are needed. Objectives We investigated the effects of a cleanser with 5‐aminolevulinic acid and peptides on mild to moderate acne vulgaris. Methods Sixty volunteers with mild to moderate acne vulgaris (IGA grade II–III) were randomly assigned to treatment or control groups of thirty respectively. Participants cleansed their faces twice a day for 8 weeks with either a cleanser with 5‐aminolevulinic acid and peptides (treatment) or with basic cleanser (control). The number of acne lesions (comedones, papules, pustules, and nodules), Michaelson's acne severity, and IGA were measured every 2 weeks and patient satisfaction and adverse events at week 8. Results Mean number of inflammatory acne lesions in treatment group decreased from 5.9 at baseline to 4.5 at week 4 and 4.1 at week 8 (in particular, P < .05). The mean number of noninflammatory lesions in treatment group decreased from 11.4 at baseline to 8.8 at week 4 and 7.4 at week 8 (in particular, P < .05). The mean value of Michaelson's acne severity index and IGA in treatment group also decreased from baseline to week 4 and week 8 (both in particular, P < .05). Investigator's assessment and patient satisfaction in treatment group at week 8 were better than control group. Adverse events in two groups were similar. Conclusions We think the cleanser with 5‐aminolevulinic acid and peptides is a useful and safe therapeutic agent for mild to moderate acne vulgaris.

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“…Acne vulgaris is a common self‐limited skin disorder of the pilosebaceous units primarily in adolescents . It can be controlled by local, systemic, hormonal, or surgical therapies .…”

Section: Introductionmentioning

confidence: 99%

Randomized controlled double‐blind study of a cleanser composed of 5‐aminolevulinic acid and peptides on mild and moderate acne vulgaris

Lee

Kim

Park

et al. 2019

J of Cosmetic Dermatology

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“…IGF-1 stimulated keratinocyte proliferation and reduced differentiation through PI3K/Akt/FoxO1 pathway, while isotretinoin reinforced FoxO1 expression, probably through p53, promoting keratinocyte differentiation. [89] Androgens and IGF-1 are interconnected in activating inflammation, [11,18,19,51,90] and elevated levels of pro-inflammatory cytokines are associated with keratinocyte proliferation and hyperkeratinization. [1,86,91] acnes.…”

Section: Cell Proliferation/differentiation Rate Correlated To Andrmentioning

confidence: 99%

Acne as an altered dermato‐endocrine response problem

Briganti

Flori

Mastrofrancesco

et al. 2020

Experimental Dermatology

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Acne is the most common skin disease in adolescent Westernized populations. Several data support the involvement of the mammalian target of rapamycin complex 1 (mTORC1) signalling in the interplay between androgens, insulin, insulin-like growth factor (IGF1) and high-glycaemic index diet in acne. The peroxisome proliferator-activated receptor γ (PPARγ) is involved in both differentiation and anti-inflammatory response. Low differentiated sebocytes showed decreased expression of PPARγ and increased level of insulin and IGF-1 receptors, resulting in the production of acne-like sebum and inflammatory mediators. In this viewpoint, we discuss how in acne the dysregulation of proliferation and differentiation processes in sebocytes and keratinocytes may be associated with altered response to androgens and other hormones, such as insulin or IGF-1. Moreover, we propose PPARγ modulation as an innovative therapeutic approach to normalize sebocyte differentiation process, interfering with the different mechanisms involved in altered pilosebaceous unit.

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“…In a study by Carmina in 2001, finasteride was effective in treating acne in hyperandrogenic women with polycystic ovarian disease 21 . In a clinical trial study in 2015, the efficacy of finasteride on severe nodulocystic acne in men was evaluated and delineated 22 . We conducted this study owing to paucity of literature regarding the efficacy of montelukast and finasteride in treating moderate acne.…”

Section: Introductionmentioning

confidence: 99%