Acne Vulgaris

Zaenglein, Andrea L.

doi:10.1056/nejmcp1702493

Cited by 148 publications

(175 citation statements)

References 46 publications

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“…Acne vulgaris is a common inflammatory skin disorder of the pilosebaceous units (1). Acne vulgaris affects 9.4% of the general population across the world.…”

Section: Introductionmentioning

confidence: 99%

“…Acne vulgaris lesions primarily occur on the face, and thus may negatively affect patients' quality of life. It has been suggested that acne can lead to psychological diseases such as anxiety, low self-worth, and depression among adolescents and adults (1).…”

Section: Introductionmentioning

confidence: 99%

“…Isotretinoin has both an anti-inflammatory effect and comedolytic activity. Moreover, isotretinoin reduces sebum production and Cutibacterium acnes concentration (1). Despite its anti-inflammatory effect by downregulating toll-like receptor 2 expression on monocytes and neutrophil migration, the exact mechanism of action of isotretinoin has not been clearly identified yet (6).…”

Section: Introductionmentioning

confidence: 99%

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Is mean platelet volume an inflammatory marker in acne patients treated with isotretinoin?

Tamer

Yüksel

Avcı³

2019

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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Introduction: Isotretinoin is a commonly used systemic retinoid for treating acne. However, isotretinoin may lead to elevated serum levels of triglycerides and cholesterol, and it may affect liver function tests. Moreover, the effect of isotretinoin on hematological parameters remains controversial. This study examines changes in the blood chemistry panel, hematological parameters, and inflammation biomarkers of patients diagnosed with acne and treated with isotretinoin. Methods: The study included 70 patients (59 females and 11 males, between ages 18 and 37) with moderate to severe acne vulgaris treated with isotretinoin. The medical records and laboratory findings of the participants were reviewed retrospectively between March 2017 and September 2018. All the patients whose necessary laboratory test results could be obtained from the collected data were included in the study. Results: Serum total cholesterol, HDL, LDL, triglyceride, mean corpuscular hemoglobin levels, and platelet/lymphocyte ratio increased, whereas white blood cell count and mean platelet volume (p = 0.036) decreased after isotretinoin treatment. Conclusions: The results of this study revealed that mean platelet volume decreased significantly 3 months after the initiation of isotretinoin treatment. Therefore, we suggest considering mean platelet volume as an inflammatory marker in patients with acne treated with isotretinoin. However, this research should be replicated under more randomized conditions in a prospective study to reach a definitive conclusion.

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“…Acne vulgaris is a common inflammatory skin disorder of the pilosebaceous units (1). Acne vulgaris affects 9.4% of the general population across the world.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is mean platelet volume an inflammatory marker in acne patients treated with isotretinoin?

Tamer

Yüksel

Avcı³

2019

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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“…Acne is a chronic inflammatory disease and the most common dermatological disease [1], affecting about 85% teenagers worldwide, and it can persist into adulthood [2]. The disease can cause negative psychosocial consequences for the affected individual, including diminished self-esteem, social withdrawal due to embarrassment, depression, and unemployment, thus adequate therapy is needed [3].…”

Section: Introductionmentioning

confidence: 99%

Stem cell membrane-coated isotretinoin for acne treatment

et al. 2020

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Background: Topical isotretinoin is commonly used to treat acne. However, topical isotretinoin has side effects and can hardly permeate through the stratum corneum, the most important skin barrier. Therefore, this study aimed to demonstrate the efficacy of nanoparticles as stable carriers with great curative effects, low side effects, and strong transdermal ability. Results: In a rabbit model of hyperkeratinization, STCM-ATRA-NPs showed significant therapeutic efficacy. By contrast, negative therapeutic efficacy was observed in a golden hamster model of hyper sebum production. Scanning electron microscopy and Fourier transform infrared spectral analyses showed that nanoparticles could penetrate the stratum corneum. Western blotting demonstrated that the nanoparticles could enhance the transdermal efficacy of isotretinoin by reducing the effect of keratin and tight junction proteins. Further, nanoparticles enhanced endocytosis, thereby promoting drug penetration and absorption into the skin. Conclusion: STCM-ATRA-NPs were demonstrated to control isotretinoin release, reducing its side effects, and efficiently permeating through the skin by reducing the effect of keratin and tight junction proteins and enhancing endocytosis.

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“…Acne is a chronic in ammatory disease and the most common dermatological disease [1], affecting about 85% teenagers worldwide, and it can persist into adulthood [2]. The disease can cause negative psychosocial consequences for the affected individual, including diminished self-esteem, social withdrawal due to embarrassment, depression, and unemployment, thus adequate therapy is needed [3].…”

Section: Introductionmentioning

confidence: 99%

Stem cell membrane-coated isotretinoin for acne treatment

Wang

Jiang

Meng

et al. 2020

Preprint

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Abstract Background：Topical isotretinoin is commonly used to treat acne. However, topical isotretinoin has side effects and can permeate through the stratum corneum, the most important skin barrier. Therefore, this study aimed to demonstrate the efficacy of nanoparticles as stable carriers with great curative effects, low side effects, and strong transdermal ability. Results: In a rabbit model of hyperkeratinization, STCM-ATRA-NPs showed significant therapeutic efficacy. By contrast, negative therapeutic efficacy was observed in a golden hamster model of hyper sebum production. Scanning electron microscopy and Fourier transform infrared spectral analyses showed that nanoparticles could penetrate the stratum corneum. Western blotting demonstrated that the nanoparticles could enhance the transdermal efficacy of isotretinoin by reducing the effect of keratin and tight junction proteins. Further, nanoparticles enhanced endocytosis, thereby promoting drug penetration and absorption into the skin.Conclusion: STCM-ATRA-NPs were demonstrated to control isotretinoin release, reducing its side effects, and efficiently permeating through the skin by reducing the effect of keratin and tight junction proteins and enhancing endocytosis.

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Acne Vulgaris

Cited by 148 publications

References 46 publications

Is mean platelet volume an inflammatory marker in acne patients treated with isotretinoin?

Is mean platelet volume an inflammatory marker in acne patients treated with isotretinoin?

Stem cell membrane-coated isotretinoin for acne treatment

Stem cell membrane-coated isotretinoin for acne treatment

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