Acne scarring: A review of available therapeutic lasers

Cohen, Beverly S.; Brauer, Jeremy A.; Geronemus, Roy G.

doi:10.1002/lsm.22410

Cited by 52 publications

(65 citation statements)

References 74 publications

(257 reference statements)

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“…Although a significant difference was not found between the two groups, the subjective scale was slightly higher in group F than in group D. The efficacy of nonablative 1550-nm fractional laser was reported for the treatment of acne scarring. 16,17 In one case series, two patients with acne improved in erythema after 5-6 months of the laser treatment. 18 Therefore, the difference in patients' subjective scales observed between the groups could be due to these additional effects of nonablative fractional laser.…”

Section: Discussionmentioning

confidence: 99%

Nonablative fractional laser‐assisted daylight photodynamic therapy with topical methyl aminolevulinate for moderate to severe facial acne vulgaris: Results of a randomized and comparative study

Kim

Ahn

Kang

et al. 2017

Photoderm Photoimm Photomed

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Section: Discussionmentioning

confidence: 99%

Nonablative fractional laser‐assisted daylight photodynamic therapy with topical methyl aminolevulinate for moderate to severe facial acne vulgaris: Results of a randomized and comparative study

Kim

Ahn

Kang

et al. 2017

Photoderm Photoimm Photomed

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“…However, the safety and efficacy profiles of all these therapies is often considered as problematic, and several studies demonstrated that these treatments are not capable of affecting all etiological factors involved in acne pathogenesis . Therefore, there is an urgent need to further develop alternative and innovative treatments, such as light, laser, and photodynamic therapies (PDT) . Light and laser therapy for the treatment of acne vulgaris is based on the observation that P. acnes synthesizes chromophores such as porphyrins, more specifically, coproporphyrin .…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Therefore, there is an urgent need to further develop alternative and innovative treatments, such as light, laser, and photodynamic therapies (PDT). [6][7][8][9] Light and laser therapy for the treatment of acne vulgaris is based on the observation that P. acnes synthesizes chromophores such as porphyrins, more specifically, coproporphyrin. [10][11][12] Porphyrins enable light therapy to exert a selective cytotoxic effect on P. acnes.…”

Section: Introductionmentioning

confidence: 99%

An extension of a multicenter, randomized, split‐face clinical trial evaluating the efficacy and safety of chromophore gel‐assisted blue light phototherapy for the treatment of acne

et al. 2017

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A variety of laser/light-based devices have been reported to be effective for the treatment of acne, yet no long-term data on efficacy and safety have been published. A first 12-week clinical trial ("Main trial") recently demonstrated that the KLOX BioPhotonic System, an LED blue light device using photo-converter chromophores, can significantly improve moderate and severe facial acne vulgaris with an excellent safety profile. This Extension trial followed the Main trial, using the same BioPhotonic System, with the same dose and instructions for use, on patients having already completed treatment in the Main trial. Main objectives of this open-label long-term extension 12-week study were to evaluate the efficacy of the KLOX BioPhotonic System on the untreated hemiface during the Main trial, as well as the duration of response on the hemiface treated during the first 12-week Main trial. Despite their young age (mean age: 21.6 years) and their 12-week participation in the Main trial, 49 (54.4%) of the total number of patients who participated in the Main trial enrolled in this additional 12-week Extension trial. Baseline grading of acne was performed with the Investigator's Global Assessment (IGA) scale. For each patient, the hemiface randomly selected as a control during the Main trial received 6 weeks of treatment (twice weekly) and was then followed up for an additional 6 weeks. The first hemiface treated in the Main trial was consequently observed throughout the Extension trial, allowing for a further 12-week assessment of outcomes (total 24 weeks). In light of an additional 12 weeks of treatment on the contralateral face, the patient compliance rate was excellent, with 91.9% of the total number of patients receiving at least 80% of the treatments.Patients with a baseline IGA grade of 2 (mild) on the treated hemiface demonstrated a success rate of 58.3 and 66.7% at weeks 6 and 12, respectively. At these same time points, subjects with a baseline IGA grade of 3 (moderate) demonstrated a success rate of 81.8 and 90.0%. Patients with a baseline IGA grade of 4 (severe) demonstrated a success rate of 100% at both week 6 and week 12. When evaluating the originally treated hemifaces from the Main trial, the rate of return to baseline at 24 weeks was calculated to be 15.5%. This latter outcome confirmed the long duration of effect following treatment.The patient safety profile was also excellent, with very few related adverse events. The BioPhotonic System, which is comprised of LED blue light phototherapy and photoconverter chromophores, provides long-term efficacy and safety in the treatment of acne vulgaris, with a rate of compliance above what is generally observed in a young population of patients suffering from acne vulgaris, especially in light of sequential enrollment in a study treating one hemiface.

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“…Various therapeutic lasers are available for acne scar . Laser procedures for acne can cause persistent erythema or pigmentary changes and may lead to legal disputes .…”

Section: Discussionmentioning

confidence: 99%

Analysis of acne‐related judicial precedents from 1997 to 2018 in South Korea

Cho

Shin

Yang

et al. 2019

The Journal of Dermatology

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Medicolegal disputes are increasing in practical medicine. Medications or procedures related to acne could lead to medical malpractice. This study analyzed medical litigation associated with acne in South Korea. Acne‐related judgments were searched using the Supreme Court of Korea’s Written Judgment Management System based on the keyword “acne”. Eleven cases were selected; eight cases were related to acne scar and three cases were related to acne. Treatment modalities such as peeling, laser treatment, photodynamic therapy and antibiotics resulted in lawsuits. Claimed sequelae of the treatments were hyperpigmentation, scar worsening, erythema, skin bumps and liver transplant. Eight cases were awarded to the plaintiff, and the others were dismissed. This study shows that various treatments for acne can cause medical disputes.

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Acne scarring: A review of available therapeutic lasers

Abstract: We sought to provide a framework for understanding the various types of lasers available to treat acne scars and review the primary literature pertaining to the efficacy, safety, and advantages of each laser discussed.

Cited by 52 publications

References 74 publications

Nonablative fractional laser‐assisted daylight photodynamic therapy with topical methyl aminolevulinate for moderate to severe facial acne vulgaris: Results of a randomized and comparative study

Nonablative fractional laser‐assisted daylight photodynamic therapy with topical methyl aminolevulinate for moderate to severe facial acne vulgaris: Results of a randomized and comparative study

An extension of a multicenter, randomized, split‐face clinical trial evaluating the efficacy and safety of chromophore gel‐assisted blue light phototherapy for the treatment of acne

Analysis of acne‐related judicial precedents from 1997 to 2018 in South Korea

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