Acne keloidalis nuchae in Latin America: is there a different phenotype?

Loayza, Enrique; Vanegas, Emanuel; Chérrez, Annia; Chérrez-Ojeda, Iván

doi:10.1111/ijd.13783

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…Although not completely understood, the etiopathogenesis of AKN is believed to be multifactorial. A few papers have suggested that insulin resistance (IR) and metabolic syndrome (MetS) might be included among these factors [6,[8][9][10][11]. Obesity, in spite of being commonly seen in patients with IR and MetS, as a risk factor for AKN has yet to be studied.…”

Section: Introductionmentioning

confidence: 99%

High Frequency of Obesity in Acne Keloidalis Nuchae Patients: A Hypothesis from a Brazilian Study

Matsunaga¹,

Tortelly²,

Machado³

et al. 2020

Skin Appendage Disord

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• Acne keloidalis nuchae (AKN) is a chronic inflammatory condition that almost exclusively affects the occipital and nape areas, being much more common in men, especially in African descendants from puberty to 50 years of age. • AKN has long been associated with friction and local trauma due to shirt collars, hats, helmets, and close shaves as triggering factors. Furthermore, keratinization disorders of genetic origin, folliculitis decalvans, seborrhea, increased androgen levels, the use of some medications, and metabolic syndrome have also been cited as possible causes. Novel Insights • Overweight and obesity per se might be related to the development of acne keloidalis nuchae (AKN). Even though insulin resistance and metabolic syndrome are frequently present in patients with high BMI, this is not always true. A high frequency of obesity in patients with AKN suggests these 2 conditions may be concurrent. • Redundant skin folds in the nape of patients with obesity might act as a trigger for the development of AKN in predisposed patients. Adipose tissue accumulation in the nape, the only moving part of the scalp, would deepen local skin creases, leading to constant trauma and an inflammatory process that could be part of the etiopathogenesis of AKN.

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Section: Introductionmentioning

confidence: 99%

High Frequency of Obesity in Acne Keloidalis Nuchae Patients: A Hypothesis from a Brazilian Study

Matsunaga¹,

Tortelly²,

Machado³

et al. 2020

Skin Appendage Disord

View full text Add to dashboard Cite

show abstract

“…Other potential factors include autoimmunity, increased androgen levels or sensitivity to androgens, seborrhea, and the use of some medications such as cyclosporine. 4 In FD it is speculated that the disease reflects an abnormal inflammatory response to Staphylococcus aureus, but the exact role of the bacteria still remains to be ascertained. 5 The (Fig.…”

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confidence: 99%