Acne inversa complicated by Actinomyces neuii

Nedomansky, Jakob; Weiss, Doris; Willinger, Birgit; Nickl, Stefanie; Steininger, Christoph

doi:10.1007/s15010-015-0814-6

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…Classical actinomycosis manifests clinically as chronic, granulomatous abscess with tissue fibrosis and draining sinuses and unresponsiveness to empiric antimicrobial therapy of a presumed abscess. The face and neck are the most common sites of actinomycosis in humans followed by thoracic, abdomino-pelvic, cerebral and skin infections 26 . Actinomycosis is generally considered an uncommon disease that affects patients of all ages and can appear in both immunocompetent and immunocompromised individuals 27 .…”

Section: Discussionmentioning

confidence: 99%

The association of medication-related osteonecrosis of the jaw with Actinomyces spp. infection

Russmueller

Seemann

Weiss

et al. 2016

Sci Rep

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Medication-related osteonecrosis of the jaw (MRONJ) represents a complication of bisphosphonate treatment that responds poorly to standard treatment. In a retrospective cohort study we investigated a possible role of Actinomyces spp. in the pathogenesis of MRONJ. Deep biopsies of necrotic bone were collected during surgical treatment of MRONJ and evaluated by histology and microbiology for the presence of Actinomyces spp. Microbiological, demographic and clinicpathological data were analyzed for risk of Actinomyces-associated MRONJ. Between 2005 and 2014, 111 patients suffering from histologically-confirmed MRONJ were identified. Actinomyces spp. were detected in 99 cases (89%) by histology and in six further patients by microbiological culture. A diverse microbial flora was found in all specimens without association with Actinomyces spp. Demographic and clinicopathological characteristics did not separate significantly Actinomyces-positive from Actinomyces-negative cases. Our observations confirm previous reports of a high prevalence of Actinomyces spp. in MRONJ in the single largest cohort available up to now. The high prevalence of Actinomyces spp. and the lack of clinicopathological risk factors underline the prominent role of Actinomyces spp. in MRONJ and may change the current understanding of MRONJ. Established prolonged antimicrobial treatment regimens against Actinomyces spp. infection could therefore be a mainstay of future MRONJ management.

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Section: Discussionmentioning

confidence: 99%

The association of medication-related osteonecrosis of the jaw with Actinomyces spp. infection

Russmueller

Seemann

Weiss

et al. 2016

Sci Rep

Self Cite

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“…For this reason, it is important to treat possible infections before starting immunosuppressive treatment for HS 12. Actinomyces has also been previously reported in the setting of diverticular disease and/or abdominal mass 13–15…”

Section: Discussionmentioning

confidence: 93%

Hidradenitis suppurativa, neutrophilic dermatoses and diverticular disease in a young African-American patient

Darji

Dhandha

Guo³

2017

BMJ Case Reports

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Hidradenitis suppurativa (HS) is a chronic skin disorder of the terminal follicular epithelium of apocrine sweat glands, manifesting as painful and exudative papules, pustules, cysts or nodules. This inflammatory condition often presents with other systemic and cutaneous disorders. We present the case of an African-American man with HS who was also diagnosed with neutrophilic dermatoses and diverticular disease. Neutrophilic dermatosis was identified based on histopathology findings. Our patient underwent multiple surgeries for flaring of his skin condition. Colchicine and doxycycline were started, but the patient was not able to tolerate them. Humira was planned for treatment of HS and neutrophilic dermatosis but could not be pursued because of the pericolic abscess. Colonoscopy and radiological investigation revealed multiple colonic diverticuli, for which he initially underwent percutaneous drainage followed by surgical removal of sigmoid mass and colocutaneous fistula. Culture from the specimen revealed abnormal growth of .

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“…Nodules secondary to deep dermatophytosis in patients with HS can also be mistaken for the malignant transformation of chronically affected HS skin, which is a known association [97][98][99]. The rapid identification of such pathogens, including slow-growing organisms such as Actinomyces neuii is essential in avoiding confounding symptomatology [100].…”

Section: Cutaneous Dysbiosis In Hidradenitis Suppurativamentioning

confidence: 99%

The Clinical Relevance of the Microbiome in Hidradenitis Suppurativa: A Systematic Review

2021

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Hidradenitis suppurativa is a chronic disease of the pilosebaceous unit. The name of the condition is a testament to the presumed relationship between the disease and the microbiome. The pathophysiology of hidradenitis suppurativa is, however, complex and believed to be the product of a multifactorial interplay between the interfollicular epithelium, pilosebaceous unit, microbiome, as well as genetic and environmental factors. In this review we assimilate the existing literature regarding the role played by the human microbiome in HS in various contexts of the disease, including the pathophysiologic, therapeutic, and potentially, diagnostic as well prognostic. In conclusion, the role played by the microbiome in HS is extensive and relevant and can have bench-to-bedside applications.

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Acne inversa complicated by Actinomyces neuii

Cited by 6 publications

References 10 publications

The association of medication-related osteonecrosis of the jaw with Actinomyces spp. infection

The association of medication-related osteonecrosis of the jaw with Actinomyces spp. infection

Hidradenitis suppurativa, neutrophilic dermatoses and diverticular disease in a young African-American patient

The Clinical Relevance of the Microbiome in Hidradenitis Suppurativa: A Systematic Review

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