Acné inducido por vitamina B 12

Ezquerro, Iñigo Martínez de Espronceda; Jaime, Saioa Oscoz; Bayona, Juan Ignacio Yanguas

doi:10.1016/j.medcli.2018.01.002

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…The total amount of iScience Article extracted porphyrins was quantified colorimetrically using a coproporphyrin III tetramethyl ester standard curve, and porphyrin production was found to be significantly higher in acne-associated C. acnes strains (p = 0.0014) (Figure 6). It had previously been observed that vitamin B12 supplementation increased porphyrin production in acne-associated strains but not in health-associated strains (Johnson et al, 2016), and this vitamin B12 supplementation resulted in the development of acne in a subset of the population only, confirming the importance of porphyrins in acne pathogenesis (Martínez De Espronceda Ezquerro et al, 2018;Balta and Ozuguz, 2014;Kang et al, 2015). Differences in porphyrin composition between strains were not investigated, as previous studies have reported similar compositions for different isolates (Johnson et al, 2016;Schaller et al, 2005).…”

Section: Acnes Porphyrins Activate the Nlrp3 Inflammasomementioning

confidence: 97%

Porphyrins produced by acneic Cutibacterium acnes strains activate the inflammasome by inducing K+ leakage

et al. 2021

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Summary Some Cutibacterium acnes subgroups dominate on healthy skin, whereas others are frequently acne associated. Here we provide mechanistic insights into this difference, using an anaerobic keratinocyte-sebocyte- C. acnes co-culture model. An acneic C. acnes strain as well as its porphyrins activates NRLP3 inflammasome assembly, whereas this was not observed with a non-acneic strain. Low levels of intracellular K + in keratinocytes stimulated with extracted porphyrins or infected with the acneic strain were observed, identifying porphyrin-induced K + leakage as trigger for inflammasome activation. Using a panel of C. acnes strains, we found that porphyrin production and IL-1β release are correlated and are higher in acneic strains. This demonstrates that the latter produce more porphyrins, which interact with the keratinocyte cell membrane, leading to K + leakage, NLRP3 inflammasome activation, and IL-1β release and provides an explanation for the observation that some C. acnes strains are associated with healthy skin, whereas others dominate in acneic skin.

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Section: Acnes Porphyrins Activate the Nlrp3 Inflammasomementioning

confidence: 97%

Porphyrins produced by acneic Cutibacterium acnes strains activate the inflammasome by inducing K+ leakage

et al. 2021

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“…25 Acne due to vitamin B12 treatment usually resolves completely after treatment cessation. [26][27][28][29] Apart from dermal reactions, cumulative adverse effects of vitamin B12 high-dose and long-term treatment are unknown. Several randomized placebocontrolled trials provide evidence on long-term use of high-dose vitamin B12 by oral route for up to 7 years without mentioning signs of overdosage or reporting sideeffects different from placebo.…”

Section: Introductionmentioning

confidence: 99%

Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review

Calderón-Ospina¹,

Nava-Mesa²,

Paez-Hurtado³

2020

TCRM

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The neurotropic B vitamins B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) are essential for proper functioning of the nervous system. Deficiencies may induce neurological disorders like peripheral neuropathy (PN) and mainly occur in vulnerable populations (eg, elderly, diabetics, alcoholics). As epidemiologic cohort studies raised safety concerns about vitamin B6/B12 intake being potentially associated with increased risks of hip fracture (HF) and lung cancer (LC), we explored these aspects and performed comprehensive literature searches. However, we suggest not to neglect actual high-risk factors (eg, smoking in LC, higher age in HF) by focusing on individual nutrients, but to examine the complex interaction of numerous factors involved in disease development. Because it warrants continued consideration, we also provide an update on neurotoxicity associated with vitamin B6. We consider that neurological side effects due to vitamin B6 intake are rare and only occur with high daily doses and/or longer treatment duration. The benefit-risk ratio of high-dose treatment with neurotropic B vitamins in indications like PN is therefore considered advantageous, particularly if dosing recommendations are followed and serum levels monitored.

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“…Sin embargo, los mecanismos aún están dilucidándose y se tratan de procesos moleculares tanto del huésped como del microorganismo (Propionibacterium acnes) (9).…”

Section: Introductionunclassified

Acné en alumnos de medicina humana y sus factores asociados

Flores-Rojas

Cabello-Carlos

Paucar-Lescano

2020

Rev Peru Investig Salud

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Introducción: El acné es una enfermedad inflamatoria crónica de la unidad pilosebácea de origen multifactorial presente en cara, espalda y pecho. En este estudio quisimos conocer cuál era la frecuencia y los factores asociados a la presencia de acné en los estudiantes de medicina. Materiales y Métodos: Se realizó un estudio de casos y controles, en alumnos de 1° a 5° año de la escuela de Medicina de la Universidad Nacional Hermilio Valdizán. Se consideró un IC de 95% con un alfa de 0,05 y una potencia de 80% con una beta igual a 0,20. Resultados: La media de la edad fue de 22,31 + 3,22 años. El consumo de frutas obtuvo significancia (p=0,04; OR=6,09) como factor protector. La ansiedad no fue significativa (p=0,59; OR=1,34), asi como el estado nutricional (p=0,57; OR=1,14) y el consumo de suplemento vitamínico B (p=0,35; OR=0,56). Se encontró significancia en la herencia biológica (p=0,01; OR=3,74 con rango inferior=10,61 y rango superior=1,31). Conclusiones: El consumo frecuente de frutas demostró actuar como factor protector en el desarrollo de acné; además, se concluye también que la herencia biológica juega un papel importante en el mismo.

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Acné inducido por vitamina B 12

Cited by 5 publications

References 4 publications

Porphyrins produced by acneic Cutibacterium acnes strains activate the inflammasome by inducing K+ leakage

Porphyrins produced by acneic Cutibacterium acnes strains activate the inflammasome by inducing K+ leakage

Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review

Acné en alumnos de medicina humana y sus factores asociados

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