Acne in the first three decades of life: An update of a disorder with profound implications for all decades of life

Greydanus, Donald E.; Azmeh, Roua; Cabral, Maria Demma; Dickson, Cheryl; Patel, Dilip R.

doi:10.1016/j.disamonth.2020.101103

Cited by 40 publications

(39 citation statements)

References 463 publications

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“…It should be added that hydrogen purification is not a treatment and cannot displace dermatological methods [ 52 , 54 ]. However, it can support the other dermatological drug and topical therapies [ 27 ] in moisturizing and reduce the level of sebum and skin lesions among people with mild and moderate acne.…”

Section: Discussionmentioning

confidence: 99%

Effects of Topical Hydrogen Purification on Skin Parameters and Acne Vulgaris in Adult Women

2021

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Background: Acne vulgaris is a prevalent dermatological disease characterized by skin eruptions, which may decrease the sufferer’s quality of life. Hydrogen purification treatment is a new procedure used in cosmetology to improve the skin parameters of the face. This study examined the effectiveness of hydrogen purification treatment to improve women’s skin conditions with regard to acne vulgaris. Methods: In this study, 30 women participated who suffered from a high level of sebum and acne. The control group was comprised of 30 healthy women with a low level of sebum. The Hellgren–Vincent Scale and Derma Unit SSC 3 device were used to assess acne vulgaris severity and skin properties, respectively. Four hydrogen purification sessions were carried out at 7-day intervals, using the Hebe Hydrogenium+ generating alkaline water. Results: At baseline and 7 and 14 days after finishing the series of treatments, the levels of oiliness, moisture, and skin pH were tested. The main effects of treatment were significant in the following parameters: pH around the bottom lip, moisture between the eyebrows and around the nose, and oily skin in all three face sites. Conclusions: The level of sebum decreased and moisture levels increased during hydrogen purification. Topical hydrogen purification is an effective and safe treatment for acne vulgaris.

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Section: Discussionmentioning

confidence: 99%

Effects of Topical Hydrogen Purification on Skin Parameters and Acne Vulgaris in Adult Women

2021

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“…Increased androgen production, the accumulation of sebum, and the adhesiveness of keratinocytes lead to follicle blockage and the occlusion of the pilosebaceous ducts, resulting in the formation of microcomedones that are the primary type of acne lesions [7,64]. These hard structures, microcomedones, are formed within the hair follicle, more precisely in the infundibulum, and are connected with the sebaceous gland via a keratinized duct.…”

Section: Comedogenesismentioning

confidence: 99%

“…IL-1 also contributes to sebocytes hypercornification. Comedone formation is a result of a combination of some factors, such as the response to androgen production; sebum alteration, production, and oxidation; C. acnes proliferation, and recruitment of cytokines to the pilosebaceous unit [7].…”

Section: Comedogenesismentioning

confidence: 99%

“…The main factors involved in acne pathogenesis are hormonal disequilibrium, exacerbated sebum production, follicular keratinization, and Cutibacterium acnes proliferation (formerly Propionibacterium acnes), resulting in an immune response and consequent inflammation [4]. Acne is the cause of 14% of primary care and 27% of dermatology consultations in the US, and first line treatment implies long periods of the use of antibiotics (up to three months, each time), oral and/or topical, usually complemented with retinoids, benzoyl peroxide, and oral contraceptives, among others [7]. In the last few years, C. acnes' resistance to the antibiotics most often used in acne treatment (erythromycin, clindamycin, and tetracycline, for example) has emerged [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care

Januário

Félix

et al. 2021

Pharmaceutics

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Acne vulgaris (AV) is a chronic skin disease of the pilosebaceous unit affecting both adolescents and adults. Its pathophysiology includes processes of inflammation, increased keratinization, sebum production, hormonal dysregulation, and bacterial Cutibacterium acnes proliferation. Common AV has been treated with antibiotics since the 1960s, but strain resistance has emerged and is of paramount concern. Macroalgae are known producers of substances with bioactive properties, including anti-viral, antibacterial, antioxidant, and anti-inflammatory properties, among several others. In particular, red algae are rich in bioactive compounds such as polysaccharides, phenolic compounds, lipids, sterols, alkaloids, and terpenoids, conferring them antioxidant, antimicrobial, and anti-inflammatory activities, among others. Thus, the exploration of compounds from marine resources can be an appealing approach to discover new treatment options against AV. The aim of this work is to provide an overview of the current knowledge of the potentialities of red macroalgae in the treatment of AV by reviewing the main therapeutic targets of this disease, and then the existence of compounds or extracts with bioactive properties against them.

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“…Acne vulgaris is a chronic inflammatory disorder of pilosebaceous glands. At increased densities, sebaceous glands appear on the face, chest, back, and shoulders 1 . Acne usually develops on the face due to the presence of a greater number of sebaceous glands compared with other parts of the body.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the effectiveness of chemical peelings in the treatment of acne vulgaris assessed using high‐frequency ultrasound—A comparative study

Zdrada

Odrzywołek

Deda

et al. 2021

J of Cosmetic Dermatology

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Background The use of high‐frequency ultrasound for noninvasive assessment of skin during chemical peeling therapies may be a useful tool. Aims To determine whether high‐frequency ultrasound is a useful tool to noninvasive assessment of skin and evaluation therapy progress. Patients/Methods The 14 women underwent four treatments with chemical peelings at 2‐week intervals. Before, after 4 weeks and after 9 weeks, photographic documentation and scans were recorded using a high‐resolution ultrasound system. Results As a result of applying pyruvic acid peeling, the thickness of the entrance echo on the forehead, cheek, and chin was reduced. After applying the peeling consisting of a mixture of glycolic and salicylic acids, the thickness of the entrance echo of the epidermis decreased on the forehead, cheek, and chin. As a result of applying a 50% pyruvic acid peeling, the density of dermis on the forehead, cheeks, and chin increased. A similar increase in the density of dermis was observed on the forehead, cheeks, and chin after applying a mixture of glycolic and salicylic acid. Conclusion High‐frequency ultrasound is a useful tool for monitoring the progress in the treatment of acne vulgaris using chemical peelings.

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Acne in the first three decades of life: An update of a disorder with profound implications for all decades of life

Cited by 40 publications

References 463 publications

Effects of Topical Hydrogen Purification on Skin Parameters and Acne Vulgaris in Adult Women

Effects of Topical Hydrogen Purification on Skin Parameters and Acne Vulgaris in Adult Women

Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care

Analysis of the effectiveness of chemical peelings in the treatment of acne vulgaris assessed using high‐frequency ultrasound—A comparative study

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