Acne antibiotic prescription pattern in Colombia

Cely, H.C. Pérez; Rincón, Elkin Javier Casadiego; Lorduy, H.

doi:10.23736/s0392-0488.19.06346-6

Cited by 1 publication

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although medications recommended by various guidelines are generally supported by high-quality randomized controlled trials, many controversies and uncertainties still exist about comparisons between treatment options and there are markedly inconsistent drug prescribing patterns among countries and among prescriber specialties. [5][6][7][8] A network meta-analysis conducted by Stuart et al focused on topical therapies for mild-to-moderate acne, but the number of interventions in their analysis was limited. 9 In this network meta-analysis, we aim to provide a more comprehensive and detailed comparison of the common pharmacological treatments for acne, which include oral and topical medications as single or combined treatments.…”

Section: Introductionmentioning

confidence: 99%

Comparative Efficacy of Pharmacological Treatments for Acne Vulgaris: A Network Meta-Analysis of 221 Randomized Controlled Trials

Huang,

Chang,

Bolick

et al. 2023

Ann Fam Med

View full text Add to dashboard Cite

PURPOSE Acne is an extremely common skin disease with an estimated global prevalence of 9.4%. We aim to provide comprehensive comparisons of the common pharmacological treatments for acne.METHODS Randomized controlled trials comparing the efficacy of pharmacological therapies for acne vulgaris in patients of any age and sex and with a treatment duration of >2 weeks were included. PubMed and Embase databases were searched from inception until February 2022. Our prespecified primary end points were mean percentage reduction in total, inflammatory, and noninflammatory lesions. Treatment ranking was determined by P values. RESULTS There were 210 articles describing 221 trials and 37 interventions included in the analysis. Our primary analysis of percentage reduction in total lesion count had 65,601 patients enrolled. Across all trials, the mean age was 20.4 years. The median duration of treatment was 12 weeks. The median total, inflammatory, and noninflammatory lesion counts were 72, 27, and 44, respectively. The most effective treatment was oral isotretinoin (mean difference [MD] = 48.41; P = 1.00), followed by triple therapy containing a topical antibiotic, a topical retinoid, and benzoyl peroxide (BPO) (MD = 38.15; P = .95) and by triple therapy containing an oral antibiotic, a topical retinoid, and BPO (MD = 34.83; P = .90). For monotherapies, oral or topical antibiotics or topical retinoids have comparable efficacy for inflammatory lesions, while oral or topical antibiotics have less effect on noninflammatory lesions. CONCLUSIONThe most effective treatment for acne is oral isotretinoin, followed by triple therapies containing a topical retinoid, BPO, and an antibiotic. We present detailed comparisons of each intervention to serve as a practical database.

show abstract