Acitretin-loaded nanoethosomal gel for the treatment of psoriasis: Formulation, optimization,
            <i>in vitro</i>
            , and
            <i>in viv</i>
            o assessment

Peram, Malleswara Rao; Dhananjay, Chandrakant; Chandrasekhar, Nagesh; Kumbar, Vijay M; Suryadevara, Vidyadhara; Patil, Sachin R; El-Zahaby, Sally A

doi:10.1080/01932691.2023.2278492

Cited by 2 publications

(1 citation statement)

References 66 publications

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“…The results of the fluorescence microscopy study suggest that ethosomes have a greater ability to penetrate deep layers of the skin compared to the acitretin penetration rate from the gel without ethosome. The formulated ethosomal gel substantially increased the skin permeability and deposition during the ex vivo tests, while an in vivo study demonstrated a significant improvement in the therapeutic response [ 128 ].…”

Section: Current Nanotechnology-based Approaches For the Topical Trea...mentioning

confidence: 99%

Recent Approaches for the Topical Treatment of Psoriasis Using Nanoparticles

Bodnár,

Fehér,

Ujhelyi

et al. 2024

Pharmaceutics

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Psoriasis (PSO) is a chronic autoimmune skin condition characterized by the rapid and excessive growth of skin cells, which leads to the formation of thick, red, and scaly patches on the surface of the skin. These patches can be itchy and painful, and they may cause discomfort for patients affected by this condition. Therapies for psoriasis aim to alleviate symptoms, reduce inflammation, and slow down the excessive skin cell growth. Conventional topical treatment options are non-specific, have low efficacy and are associated with adverse effects, which is why researchers are investigating different delivery mechanisms. A novel approach to drug delivery using nanoparticles (NPs) shows promise in reducing toxicity and improving therapeutic efficacy. The unique properties of NPs, such as their small size and large surface area, make them attractive for targeted drug delivery, enhanced drug stability, and controlled release. In the context of PSO, NPs can be designed to deliver active ingredients with anti-inflammatory effect, immunosuppressants, or other therapeutic compounds directly to affected skin areas. These novel formulations offer improved access to the epidermis and facilitate better absorption, thus enhancing the therapeutic efficacy of conventional anti-psoriatic drugs. NPs increase the surface-to-volume ratio, resulting in enhanced penetration through the skin, including intracellular, intercellular, and trans-appendage routes. The present review aims to discuss the latest approaches for the topical therapy of PSO using NPs. It is intended to summarize the results of the in vitro and in vivo examinations carried out in the last few years regarding the effectiveness and safety of nanoparticles.

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Section: Current Nanotechnology-based Approaches For the Topical Trea...mentioning

confidence: 99%