Acinic cell-like carcinoma of the breast

Abstract

A case of infiltrating carcinoma of the breast with features similar to those seen in acinic cell carcinoma of the parotid gland is described in a 42-year-old woman. The neoplastic cells were immunoreactive with anti-lysozyme- and anti-salivary-type amylase antisera and contained electron-dense cytoplasmic globules similar to those seen in acinic cell carcinoma of salivary glands. One lymph node out of 18 was found to contain a metastatic deposit. The patient is alive and well 1 year after mastectomy. This appears to be the first case of carcinoma with acinic cell-like features reported in the breast.

Primary acinic cell carcinoma of the breast

“…The first case of acinic cell carcinoma of the breast was described by Roncaroli and colleagues 1 and this case, together with five additional cases, was subsequently included in an immunohistochemical and ultrastructural study published by Damiani et al 2 A single additional case was recently reported by Schmitt and colleagues 3 who, on the basis of their case and the initial case reported by Roncaroli, suggested that this breast carcinoma variant might be associated with a good prognosis. Their patient was alive and well 21 months after surgery and of the six patients described by Damiani, one was alive and well after five years, three were alive and well after one year, one had a recurrence after four years, and one was lost to follow up.…”

Fine Needle Aspiration Cytology of Glycogen-Rich Clear Cell Carcinoma of the Breast

“…3,6,9,10,12,14 Acinic cell carcinoma is an uncommon neoplasm of the breast composed of cells with acinar differentiation and low malignancy potential. 15 Acinic cell carcinomas are characterized by central round to oval nuclei with prominent nucleoli and abundant granular, eosinophilic to amphophilic and foamy cytoplasm. Clear cells are commonly found.…”

Acinic cell carcinoma of the breast: an immunohistochemical and ultrastructural study

“…Acinic cell carcinoma (ACC) of the breast was recognized by Roncaroli et al [26] in 1996 as the breast counterpart of identical tumors of the parotid gland.…”