Acinic cell carcinoma: A clinicopathologic study of thirty-five cases

Batsakis, John G.; Chinn, Edwin K.; Weimert, Thomas A.; Work, Walter P.; Krause, Charles J.

doi:10.1017/s0022215100087107

Cited by 72 publications

(60 citation statements)

References 20 publications

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“…However, they mentioned that the fallibility of such a grading system is characterized by the occasional aggressive behaviour of low-grade tumours. Our case 3 was quite difficult to integrate into the classification of Batsakis et al (1979); it was finally considered as a high grade type of malignancy; however its histological appearance does not fit well into the histological types described by these authors and corresponds better to that described by Perzin and LiVolsi (1979).…”

Section: Fig 7 Metastasis Of the Lungs (Arrows) (Case 3)contrasting

confidence: 55%

“…A few venous thromboses were visible beneath the mucosa. The growth pattern of this acinic cell carcinoma was in part medullary, in part acinotubular, according to Batsakis et al (1979), thus of high grade malignancy. At routine follow-up five years later, in July 1985, an ipsilateral movable cervical lymph node, measuring 20 mm in diameter, was detected.…”

Section: Pathology Reportmentioning

confidence: 85%

“…The appearance of this acinic cell carcinoma was of the medullary type according to Batsakis et al (1979), thus of high grade malignancy.…”

Section: Pathology Reportmentioning

confidence: 87%

“…Most clinicopathological analyses of acinic cell carcinomas have concluded that histopathological features are unreliable in predicting biological behaviour. Batsakis et al (1979) have described a classification of low-grade and highgrade malignancies of these tumours. However, they mentioned that the fallibility of such a grading system is characterized by the occasional aggressive behaviour of low-grade tumours.…”

Section: Fig 7 Metastasis Of the Lungs (Arrows) (Case 3)mentioning

confidence: 99%

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Acinic cell carcinoma of minor salivary gland origin

1991

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The occurrence of acinic cell carcinoma in the minor salivary glands appears to be exceptional. A review of the English language literature revealed about 80 previously reported cases. In this paper, the clinical behaviour and pathological findings in three cases are reported.The tumours took their origin from the hard palate, soft palate and lower lip. The three cases presented with malignant clinical behaviour; all three recurred. In one case the local recurrence was multinodular with capsular infiltration. Two cases developed regional lymph node metastasis, and one metasized to the lung and liver. In one the tumour infiltrated bony structures, and nerve in another. These cases tend to support the belief of some authors that acinic cell 'tumours' are clinically malignant and should be included in the carcinoma group.

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Section: Fig 7 Metastasis Of the Lungs (Arrows) (Case 3)contrasting

confidence: 55%

Section: Pathology Reportmentioning

confidence: 85%

“…The appearance of this acinic cell carcinoma was of the medullary type according to Batsakis et al (1979), thus of high grade malignancy.…”

Section: Pathology Reportmentioning

confidence: 87%

Section: Fig 7 Metastasis Of the Lungs (Arrows) (Case 3)mentioning

confidence: 99%

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Acinic cell carcinoma of minor salivary gland origin

1991

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“…Although it can be generally considered that the acinic cell carcinoma of the salivary gland may be derived from intercalated duct cells or terminal tubules [1][2][3][4], direct evidence could not be obtained within the human neoplasm. On the other hand, it has been already reported that an in vitro experimental system using a human sali vary adenocarcinoma cell line demonstrated evidence of the neoplastic intercalated duct cells being capable of multidirectional differentiation towards several pheno types.…”

Section: Introductionmentioning

confidence: 99%

Immunopathology of Phenotypic Change on Human Parotid Gland Adenocarcinoma

Deguchi

Hamano²,

Haneji³

et al. 1993

Pathobiology

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Immunopathological analysis was made of phenotypic change in a recurrent parotid gland adenocarcinoma occurring in a patient with a long clinical course of 30 years or more. At the first and second operations, in 1959 and 1978, the resected parotid gland tumors were diagnosed histopathologically as acinic cell carcinoma. However, 11 years after the second operation, in 1989, the resected recurrent tumor showed a microscopically phenotypic change towards adenocarcinoma with typical tubular arrangement. At the last operation in 1991 histopathological examination of the tumor revealed adenocarcinoma with diffuse oncocytic change in association with cervical lymph node metastasis. These findings suggest that phenotypic change may occur in vivo among human neoplasms during a long period, which may be related to the cytodifferentiation in the salivary gland tumor.

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