Acidosis láctica, hipoglucemia severa y hepatoesplenomegalia

Rodríguez, M. López; Muñoz, E. Vázquez; Cerezo, J. Gómez; Muñoz, B. Pagán; Bravo-Burguillos, Elena Ruiz; Hernández, Fernando

doi:10.1157/13111552

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Among the 10 reported cases including our case, 8 patients had a fatal outcome, with death occurring in a matter of days to weeks from the onset of lactic acidosis. In only one case, the patient was alive after 2.5 years of diagnosis and in another case the outcome was not well specified ( Table 1) [2, [14][15][16][17][18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Lactic Acidosis and Atrial Tachycardia: Unusual Presentations of Disseminated Burkitt-Like Lymphoma

El-Osta

Abdulbaki²,

Peddi³

et al. 2012

JCT

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Lactic acidosis is a rare complication of malignancies and is seen more frequently in high grade lymphoma and leukemia. Although, its pathogenesis is not well understood, it remains a surrogate of poor prognosis. Herein, we present a case of Burkitt-like lymphoma presenting with metabolic abnormalities including lactic acidosis and hypoglycemia along with atrial tachycardia. We will discuss the different mechanisms involved in these metabolic disturbances and we will provide insight on novel therapeutic strategies based on our understanding of the underlying pathophysiology

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Section: Discussionmentioning

confidence: 99%

Lactic Acidosis and Atrial Tachycardia: Unusual Presentations of Disseminated Burkitt-Like Lymphoma

El-Osta

Abdulbaki²,

Peddi³

et al. 2012

JCT

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Treating Acquired Factor VIII Inhibitor and Tumor-Induced Hypoglycemia in a Case of Relapsed Diffuse Large B-Cell Lymphoma

Baker¹,

Norton²,

Hossain³

2023

J Hematol

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Diffuse large B-cell lymphoma (DLCBL) is a heterogenous disease, with many phenotypic subtypes and occasional paraneoplastic syndromes being present. Herein, we describe a case of a 63-year-old woman, with relapsed/refractory DLBCL (RR-DLBCL) with artifactual hypoglycemia on laboratory testing, likely related to the mechanical effects of a new factor VIII inhibitor. We demonstrate our workup, consideration, treatment, and her clinical course. This patient did not present with a bleeding phenotype despite her aberrant laboratory results, and therefore determining her risk of bleeding to weigh against further diagnostic procedures presented a difficult decision. We utilized rotational thromboelastometry (ROTEM) to assist with clinical decision making regarding her paraneoplastic factor VIII inhibitor and the patient’s bleeding risk. This led to a short course of dexamethasone. Her ROTEM improved, and an excisional biopsy was performed without any bleeding. To our knowledge, this is the only reported instance where this technology was utilized in this setting. We believe utilizing ROTEM to determine bleeding risk may be a beneficial tool for clinical practice in such additional rare cases.

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Severe type-B lactic acidosis in a patient with bilateral renal Burkitt’s lymphoma

Betancourt

Valencia

Becerra-Gonzáles

et al. 2021

CNCS

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Acidosis láctica, hipoglucemia severa y hepatoesplenomegalia

Cited by 3 publications

References 7 publications

Lactic Acidosis and Atrial Tachycardia: Unusual Presentations of Disseminated Burkitt-Like Lymphoma

Lactic Acidosis and Atrial Tachycardia: Unusual Presentations of Disseminated Burkitt-Like Lymphoma

Treating Acquired Factor VIII Inhibitor and Tumor-Induced Hypoglycemia in a Case of Relapsed Diffuse Large B-Cell Lymphoma

Severe type-B lactic acidosis in a patient with bilateral renal Burkitt’s lymphoma

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