Acidity-triggered charge-convertible nanoparticles that can cause bacterium-specific aggregation in situ to enhance photothermal ablation of focal infection

Korupalli, Chiranjeevi; Huang, Chieh‐Cheng; Lin, Wei; Pan, Wen; Lin, Po‐Yen; Wan, Wei‐Lin; Li, Meng Ju; Chang, Yen; Sung, Hsing‐Wen

doi:10.1016/j.biomaterials.2016.11.045

Cited by 141 publications

(105 citation statements)

References 27 publications

Supporting

Mentioning

105

Contrasting

Order By: Relevance

“…Especially, methicillin‐resistant staphylococcus aureus (MRSA) has become a more common cause, presenting as more complex forms of subcutaneous infections. [ 37b,38 ] Thus, the efficacy of the hydrogel as a photothermal therapy agent for treating in vivo infection was evaluated by a subcutaneous abscess experiment created in mouse using MRSA (100 µL of 10 7 CFU mL −1 ). After treating for 24 h, the infected skin wounds were formed subcutaneously (Figure 5d).…”

Section: Resultsmentioning

confidence: 99%

Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing

Zhao

Liang

Huang

et al. 2020

Adv Funct Materials

564

479

View full text Add to dashboard Cite

3+ coordination cross-linked poly(glycerol sebacate)-copoly(ethylene glycol)-g-catechol and quadruple hydrogen bonding crosslinked ureido-pyrimidinone modified gelatin. It possesses excellent anti-oxidation, NIR/pH responsiveness, and shape adaptation. Additionally, the hydrogel presents rapid self-healing, good tissue adhesion, degradability, photothermal antibacterial activity, and NIR irradiation and/or acidic solution washing-assisted removability. In vivo experiments prove that the hydrogels have good hemostasis of skin trauma and high killing ratio for methicillin-resistant staphylococcus aureus (MRSA) and achieve better wound closure and healing of skin incision than medical glue and surgical suture. In particular, they can significantly promote full-thickness skin defect wound healing by regulating inflammation, accelerating collagen deposition, promoting granulation tissue formation, and vascularization. These on-demand dissolvable and antioxidant physical double-network hydrogel adhesives are excellent multifunctional dressings for treating in vivo MRSA infection, wound closure, and wound healing.

show abstract

Section: Resultsmentioning

confidence: 99%

Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing

Zhao

Liang

Huang

et al. 2020

Adv Funct Materials

564

479

View full text Add to dashboard Cite

show abstract

“…During bacterial infection cells would undergo the enhanced oxidative stress and produce ROS, especially H 2 O 2 (29) . Thus, we want to use this nanoprobe to detect bacterial infection in mice by PA imaging.…”

Section: Resultsmentioning

confidence: 99%

H ₂ O ₂ -responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay

Chen

Liang

Sun

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

468

340

View full text Add to dashboard Cite

Abnormal H 2 O 2 levels are closely related to many diseases, including inflammation and cancers. Herein, we simultaneously load HRP and its substrate, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), into liposomal nanoparticles, obtaining a Lipo@HRP&ABTS optical nanoprobe for in vivo H 2 O 2 -responsive chromogenic assay with great specificity and sensitivity. In the presence of H 2 O 2 , colorless ABTS would be converted by HRP into the oxidized form with strong near-infrared (NIR) absorbance, enabling photoacoustic detection of H 2 O 2 down to submicromolar concentrations. Using Lipo@HRP&ABTS as an H 2 O 2 -responsive nanoprobe, we could accurately detect the inflammation processes induced by LPS or bacterial infection in which H 2 O 2 is generated. Meanwhile, upon systemic administration of this nanoprobe we realize in vivo photoacoustic imaging of small s.c. tumors (∼2 mm in size) as well as orthotopic brain gliomas, by detecting H 2 O 2 produced by tumor cells. Interestingly, local injection of Lipo@HRP&ABTS further enables differentiation of metastatic lymph nodes from those nonmetastatic ones, based on their difference in H 2 O 2 contents. Moreover, using the H 2 O 2 -dependent strong NIR absorbance of Lipo@HRP&ABTS, tumorspecific photothermal therapy is also achieved. This work thus develops a sensitive H 2 O 2 -responsive optical nanoprobe useful not only for in vivo detection of inflammation but also for tumor-specific theranostic applications.hydrogen peroxide | inflammation | tumor | photoacoustic imaging | photothermal therapy

show abstract

“…Previous reports have shown that strong electrostatic interactions form between cationic‐based species and the negatively charged bacterial cell wall . With this in mind, a porphyrin functionalized with four ammonium groups (termed as Pp4N) was synthesized through modification of a previously reported method (Scheme S1, Supporting Information) .…”

Section: Resultsmentioning

confidence: 99%

A Supramolecular‐Based Dual‐Wavelength Phototherapeutic Agent with Broad‐Spectrum Antimicrobial Activity Against Drug‐Resistant Bacteria

et al. 2020

Angew Chem Int Ed

100

View full text Add to dashboard Cite

With the ever‐increasing threat posed by the multi‐drug resistance of bacteria, the development of non‐antibiotic agents for the broad‐spectrum eradication of clinically prevalent superbugs remains a global challenge. Here, we demonstrate the simple supramolecular self‐assembly of structurally defined graphene nanoribbons (GNRs) with a cationic porphyrin (Pp4N) to afford unique one‐dimensional wire‐like GNR superstructures coated with Pp4N nanoparticles. This Pp4N/GNR nanocomposite displays excellent dual‐modal properties with significant reactive‐oxygen‐species (ROS) production (in photodynamic therapy) and temperature elevation (in photothermal therapy) upon light irradiation at 660 and 808 nm, respectively. This combined approach proved synergistic, providing an impressive antimicrobial effect that led to the complete annihilation of a wide spectrum of Gram‐positive, Gram‐negative, and drug‐resistant bacteria both in vitro and in vivo. The study also unveils the promise of GNRs as a new platform to develop dual‐modal antimicrobial agents that are able to overcome antibiotic resistance.

show abstract

Acidity-triggered charge-convertible nanoparticles that can cause bacterium-specific aggregation in situ to enhance photothermal ablation of focal infection

Cited by 141 publications

References 27 publications

Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing

Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing

H ₂ O ₂ -responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay

A Supramolecular‐Based Dual‐Wavelength Phototherapeutic Agent with Broad‐Spectrum Antimicrobial Activity Against Drug‐Resistant Bacteria

Contact Info

Product

Resources

About

Acidity-triggered charge-convertible nanoparticles that can cause bacterium-specific aggregation in situ to enhance photothermal ablation of focal infection

Cited by 141 publications

References 27 publications

Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing

Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing

H 2 O 2 -responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay

A Supramolecular‐Based Dual‐Wavelength Phototherapeutic Agent with Broad‐Spectrum Antimicrobial Activity Against Drug‐Resistant Bacteria

Contact Info

Product

Resources

About

H ₂ O ₂ -responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay