Acidity-responsive cascade nanoreactor based on metal-nanozyme and glucose oxidase combination for starving and photothermal-enhanced chemodynamic antibacterial therapy

Wang, Tongyao; Dong, Dong; Chen, Tong; Zhu, Junlun; Wang, Suxiao; Wen, Wei; Zhang, Xun; Tang, Huadong; Liang, Jing; Xiong, Huayu

doi:10.1016/j.cej.2022.137172

Cited by 32 publications

(33 citation statements)

References 55 publications

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“…This temperature was adequately high to eliminate bacteria, which was confirmed in previous reports. 46–49 Furthermore, hyperthermia could improve the CDT effect of P1/GA–Fe nanoassemblies. Fig.…”

Section: Resultsmentioning

confidence: 99%

Biodegradable Fe(ii)/Fe(iii)-coordination-driven nanoassemblies for chemo/photothermal/chemodynamic synergistic therapy of bacterial infection

Dai

Liu

et al. 2022

New J. Chem.

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Section: Resultsmentioning

confidence: 99%

Biodegradable Fe(ii)/Fe(iii)-coordination-driven nanoassemblies for chemo/photothermal/chemodynamic synergistic therapy of bacterial infection

Dai

Liu

et al. 2022

New J. Chem.

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“…39,40 Interestingly, H 2 O 2 was produced by the decomposition of glucose with GOx catalyzed. 39 Therefore, the generation of •OH could be activated by 3.6. Photothermal Properties of the Glucose-Activated TMB/Fe 2+ /PF127/GOx Hydrogel.…”

Section: Glucosementioning

confidence: 99%

“…Chemodynamic therapy (CDT) based on the Fenton reaction to catalyze H 2 O 2 to generate highly toxic ROS for efficient killing bacteria, displaying merits of diabetic wound's specificity with cascade catalytic blood glucose, and depth independence. 39,40 Therefore, developing a glucoseactivated multimodal CDT/PTT agent with reducing glucose and monitoring the glucose level simultaneously is imperative for accelerating diabetic wound healing. 41−45 Herein, the Pluronic F-127 (PF127) thermosensitive hydrogel dressing combining the capabilities of colorimetric glucose sensing and glucose-activated chemodynamic/photothermal functions is designed and demonstrated for simultaneous glucose monitoring and antimicrobial therapy to accelerate diabetic wound healing.…”

Section: Introductionmentioning

confidence: 99%

Blood-Glucose-Depleting Hydrogel Dressing as an Activatable Photothermal/Chemodynamic Antibacterial Agent for Healing Diabetic Wounds

Zhu

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Poorly healing and nonhealing diabetic wounds are challenging to treat as the rapid growth of bacteria due to the high local glucose content can lead to persistent inflammation and poor angiogenesis. Herein, a smart hydrogel dressing composed of 3,3′,5,5′-tetramethylbenzidine/ferrous ion/Pluronic F-127/glucose oxidase (TMB/Fe2+/PF127/GOx) is designed and demonstrated to consume blood glucose while accelerating wound healing by generating antibacterial agents in situ. The loaded GOx degrades blood glucose to provide hydrogen peroxide (H2O2) and gluconic acid to support the Fe2+-based Fenton reaction, and the generated hydroxyl radical (·OH) facilitates the oxidation of TMB. The color change from colorless to green caused by the oxidation of TMB in the blood glucose range between 1 and 10 mM can be monitored visually. Simultaneously, this process induced chemodynamic therapy (CDT) by the specific generation of hydroxyl radical (·OH) for killing bacteria. Moreover, the oxidized TMB shows strong absorption in the near infrared (NIR) region so that NIR light can be converted into heat efficiently for photothermal therapy (PTT). As a result, nearly 100% of Staphylococcus aureus and Escherichia coli are killed by synergistic PTT/CDT, and the infected skin wounds undergo complete repair along with downregulation of interleukin-6 (IL-6) and upregulation of the vascular endothelial growth factor (VEGF) and matrix metallopeptidase-2 (MMP-2). Different from traditional wound dressings that can give rise to secondary injury, the excellent thermosensitive properties arising from the sol/gel phase transition render the hydrogel dressing materials injectable, self-reparable, and removable on demand. The multifunctional hydrogel with hypoglycemic, chemodynamic, photothermal, antibacterial, and on-demand thermosensitive properties has immense potential in the treatment of diabetic wounds.

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“…Considering that bacterial resistance is caused by the overuse and misuse of conventional antibiotics, the exploitation of nonantibiotic antibacterial treatments has been proved to be a feasible strategy to alleviate this tough issue, including chemodynamic therapy (CDT) and photothermal therapy (PTT). − Profiting from the acidic bacterial infection microenvironment containing overexpressed hydrogen peroxide (H 2 O 2 ), CDT could lead to the efficient inactivation of bacteria by the generated toxic hydroxyl radicals (·OH) via Fenton or Fenton-like reactions without inducing bacterial resistance. , Unfortunately, further application of CDT is severely limited by the inherent insufficient efficiency of Fenton or Fenton-like reactions, which is attributed to the normal body temperature range and the inadequate supply of Fe 2+ ions at the infected site. Coincidentally, the local temperature could be significantly raised to facilitate CDT through near-infrared (NIR)-mediated PTT, which could convert light energy into thermal energy with high efficiency to kill bacteria via destructive damage to the cell wall and denaturation of proteins. − Consequently, synergistic PTT/CDT has been increasingly employed to achieve an enhanced CDT for antibacterial treatment. − Meanwhile, chelating or reductive agents, which could act as an extra source of Fe 2+ ions through continuous release or persistent reduction from as-formed Fe 3+ ions, were utilized to strengthen CDT. , Apparently, further improved antibacterial therapeutic efficiency of CDT could be realized in one platform by the combination of PTT and a sufficient supply of Fe 2+ ions as dual-augmentation strategies.…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive Nanogel for Photothemal-Enhanced Chemodynamic Antibacterial Therapy

Zhao

Lan

et al. 2023

ACS Appl. Nano Mater.

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Chemodynamic therapy (CDT) and photothermal therapy (PTT) have been widely studied as treatment alternatives to anbiotics to avoid the occurrence of bacterial resistance because of their negligible bacterial resistance and high antibacterial efficiencies. Herein, we developed an infection microenvironment-responsive nanogel (STF) to successfully achieve a PTT synergized CDT for bacterial infection. Through a one-step/pot method, STF nanotherapeutics consisting of Fe3+/sodium alginate (SA) based nanogels and Fe3+/tannic acid (TA) based metal–phenolic networks (MPNs) were conveniently prepared by the coordination-triggered simultaneous self-assembly of SA, TA, and Fe3+ ions. Afterward, their photothermal and catalytic performances were intensively investigated. Moreover, the sterilization effect of the STF nanogel was evaluated through in vitro and in vivo bactericidal assays. The STF nanogel exhibited a photothermal enhanced peroxidase-like activity because of the good photothermal effect of MPNs. In addition, its Fenton activity was further accelerated by an extra amount of Fe2+ derived from the degradation of Fe3+-chelating agents (SA) and reduction of TA. Together, the STF nanogel possessed a photothermal/Fe2+ dual-augmented catalytic property. In vitro and in vivo antibacterial assays proved its satisfactory bactericidal efficiency owing to PTT/Fe2+ dual-enhanced CDT. Our research findings suggested that the developed intelligent bactericidal nanogel has great potential to be used as an antibiotic alternative to avoid bacterial resistance in future clinical treatments.

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Acidity-responsive cascade nanoreactor based on metal-nanozyme and glucose oxidase combination for starving and photothermal-enhanced chemodynamic antibacterial therapy

Cited by 32 publications

References 55 publications

Biodegradable Fe(ii)/Fe(iii)-coordination-driven nanoassemblies for chemo/photothermal/chemodynamic synergistic therapy of bacterial infection

Biodegradable Fe(ii)/Fe(iii)-coordination-driven nanoassemblies for chemo/photothermal/chemodynamic synergistic therapy of bacterial infection

Blood-Glucose-Depleting Hydrogel Dressing as an Activatable Photothermal/Chemodynamic Antibacterial Agent for Healing Diabetic Wounds

pH-Responsive Nanogel for Photothemal-Enhanced Chemodynamic Antibacterial Therapy

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