Acidification of Rat Colon With Lactulose

Charoenkul, Viratana; McElhinney, A. James; Hodgson, W. John B.

doi:10.1001/archsurg.1978.01370170080016

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…A variety of methods were employed including enemas, whole gut irrigation and/or cathartics. Several theories were proposed as the mechanisms through which MBP could reduce infectious morbidity: the empty colon was easier for the surgeon to handle, so improving technical creation of the anastomosis[ 47 ]; there would be no faecal bulk to mechanically shear the fresh anastomosis[ 48 ]; the absence of faeces would avoid intra-operative contamination that led to SSI[ 49 ]; the reduced colonic bacterial load would leave less organisms with opportunity to cause SSI[ 49 , 50 ]; and the resultant drop in luminal pH would reduce ammonia production that had a cytotoxic effect on colonic anastomoses[ 51 , 52 ].…”

Section: Literature Searchmentioning

confidence: 99%

Role of oral antibiotics for prophylaxis against surgical site infections after elective colorectal surgery

Cawich

Teelucksingh

Hassranah

et al. 2017

WJGS

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Over the past few decades, surgeons have made many attempts to reduce the incidence of surgical site infections (SSI) after elective colorectal surgery. Routine faecal diversion is no longer practiced in elective colonic surgery and mechanical bowel preparation is on the verge of being eliminated altogether. Intravenous antibiotics have become the standard of care as prophylaxis against SSI for elective colorectal operations. However, the role of oral antibiotics is still being debated. We review the available data evaluating the role of oral antibiotics as prophylaxis for SSI in colorectal surgery.

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Section: Literature Searchmentioning

confidence: 99%

Role of oral antibiotics for prophylaxis against surgical site infections after elective colorectal surgery

Cawich

Teelucksingh

Hassranah

et al. 2017

WJGS

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Healing of experimental intestinal anastomoses

Hendriks¹,

Mastboom²

1990

Diseases of the Colon &Amp; Rectum

316

210

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Anastomotic dehiscence remains a major complication in surgery of the large bowel, and studies on the healing sequence of experimental anastomoses are necessary to define underlying mechanisms and find ways to improve surgical outcome, particularly in high-risk situations. For the quantitative description of anastomotic repair, both mechanical and biochemical parameters are employed, each with their own limitations. Mechanical parameters, either bursting pressure or breaking strength, only reflect growing anastomotic strength as long as disruption occurs within the anastomotic area, which is less than one week after surgery for the bursting pressure and probably up to two weeks for the breaking strength. The biochemical description of anastomotic repair has been limited to behavior of collagen, as represented by its rather unique constituent amino acid hydroxyproline. Conclusions based on collagen concentrations--per unit weight--should be considered with caution since they may change as a consequence of changes in noncollagenous substances. In this respect, collagen content, per unit length, is probably a better parameter to describe anastomotic collagen levels. Few investigations have addressed the quality of collagen (e.g., crosslinking or type). Since, at this time, no distinct correlations have been demonstrated between development of mechanical strength or occurrence of leakage and collagen levels in the healing anastomosis, attention should not be restricted to a description of the quantity of collagen present: the quality of anastomotic collagen should be investigated, perhaps even more so.

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