Acide hyaluronique et matrice extracellulaire : une molécule primitive ?

Nusgens, Betty

doi:10.1016/s0151-9638(10)70002-8

Cited by 58 publications

(20 citation statements)

References 13 publications

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“…These minerals reinforce the natural defences of the skin in restoring the natural skin barrier, stimulating antioxidant activity and reducing inflammation, commonly observed in subjects with rosacea. [18][19][20][21][22][23][24][25] In an unpublished analysis of a global investigation concerning a subgroup of subjects with mild rosacea, M89 applied daily on the face improved clinical signs of rosacea and, according to subjects, improved their symptoms as well as skin hydration, indicating that M89 may strengthen the natural skin barrier and help to protect the skin from environmental and external aggressions. 26 The aim of our split-face study was to assess the clinical benefit of M89 compared to standard skin care in subjects with rosacea with erythema and sensitive skin after 30 days of daily use.…”

Section: Introductionmentioning

confidence: 99%

<p>A Split-Face Study Assessing the Clinical Benefit, Tolerability and Subject Satisfaction of a Dermocosmetic in Subjects with Rosacea Associated with Erythema and Sensitive Skin</p>

Berardesca¹,

Bonfigli²,

Cribier³

et al. 2020

CCID

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This study assessed the efficacy and tolerability of M89 in patients with rosacea associated with erythema and sensitive skin. Methods: Intra-individual study in a split-face design comparing after 30 days M89 twice daily and usual skin care in 20 adult subjects with rosacea and sensitive skin. M89 contains 89% Vichy volcanic mineralizing water (VVMW) and 0.4% hyaluronic acid. It is hypoallergenic and contains no perfume and this convenes in rosacea. Contained minerals reinforce the natural defences of the skin in restoring the natural skin barrier, stimulating antioxidant activity and reducing inflammation, commonly observed in subjects with rosacea. Clinical evaluations included assessment of erythema, desquamation, papules and pustules, skin tightness, dryness, burning sensation, itching, stinging and stinging test as well as local tolerability. Instrumental evaluations included skin hydration and TEWL. Subject satisfaction was assessed at Days 15 and 30. Demodex density was assessed at Day 30. Results: A significant superiority of M89 over the standard skin care was observed for erythema, skin tightness and dryness (all P≤0.05) as early as Day 15, the skin stinging test was significantly in favour of M89 (P<0.05 at Day 15 and P<0.01 at Day 30) and for skin hydration (P<0.0001) at Day 15 and 30 with no difference in mean Demodex density between M89 and usual skin care after 30 days. Tolerance was excellent and subject satisfaction very high. Conclusion: Study results concerning M89 are encouraging for its use either alone or as an adjuvant daily skin care to topical medication in patients with persistent centrofacial erythema of rosacea with no more than 3 papules and pustules.

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Section: Introductionmentioning

confidence: 99%

<p>A Split-Face Study Assessing the Clinical Benefit, Tolerability and Subject Satisfaction of a Dermocosmetic in Subjects with Rosacea Associated with Erythema and Sensitive Skin</p>

Berardesca¹,

Bonfigli²,

Cribier³

et al. 2020

CCID

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“…HA is found in almost all living organisms, being degraded and resynthesized on a daily basis in the human body. 3 HA usually exists in the extracellular matrix (ECM), which provides cells with a physical and chemical microenvironment that determines their proliferation, migration or differentiation. 4 The vascular endothelial glycocalyx, a brush-like layer located in the luminal surface of the vascular endothelium, is also rich in HA.…”

Section: Introductionmentioning

confidence: 99%

Mimicking the endothelial glycocalyx through the supramolecular presentation of hyaluronan on patterned surfaces

Pang

Landwehr

et al. 2019

Faraday Discuss.

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“…The hyaluronic acid (HA) is a large glycosaminoglycan, which serves as one of the important components of the extracellular matrix. Numerous functions have been ascribed to it, including immune activation, promotion of proliferation, migration, and intracellular signaling 25 , 26 . Its role as a mediator of MSC homing is particularly interesting as its production increases during inflammation and injury 27 .…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid coatings as a simple and efficient approach to improve MSC homing toward the site of inflammation

Corradetti

Taraballi

Martinez

et al. 2017

Sci Rep

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A major challenge in regenerative medicine is to improve therapeutic cells’ delivery and targeting using an efficient and simple protocol. Mesenchymal stem cells (MSC) are currently employed for the treatment of inflammatory-based diseases, due to their powerful immunosoppressive potential. Here we report a simple and versatile method to transiently overexpress the hyaluronic acid (HA) receptor, CD44, on MSC membranes, to improve their homing potential towards an inflammatory site without affecting their behavior. The effect of HA-coatings on murine MSC was functionally determined both, in vitro and in vivo as a consequence of the transient CD44 overexpression induced by HA. Data obtained from the in vitro migration assay demonstrated a two-fold increase in the migratory potential of HA-treated MSC compared to untreated cells. In an LPS-induced inflamed ear murine model, HA-treated MSC demonstrated a significantly higher inflammatory targeting as observed at 72 hrs as compared to untreated cells. This increased accumulation for HA-treated MSC yielded a substantial reduction in inflammation as demonstrated by the decrease in the expression of pro-inflammatory markers and by the induction of a pro-regenerative environment.

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Acide hyaluronique et matrice extracellulaire : une molécule primitive ?

Cited by 58 publications

References 13 publications

<p>A Split-Face Study Assessing the Clinical Benefit, Tolerability and Subject Satisfaction of a Dermocosmetic in Subjects with Rosacea Associated with Erythema and Sensitive Skin</p>

<p>A Split-Face Study Assessing the Clinical Benefit, Tolerability and Subject Satisfaction of a Dermocosmetic in Subjects with Rosacea Associated with Erythema and Sensitive Skin</p>

Mimicking the endothelial glycocalyx through the supramolecular presentation of hyaluronan on patterned surfaces

Hyaluronic acid coatings as a simple and efficient approach to improve MSC homing toward the site of inflammation

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