Acid‐Sensing Ion Channels and Pain

Walder, Roxanne Y.; Benson, Christopher J.; Sluka, Kathleen A.

doi:10.1002/9780470522226.ch7

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Asic: Acid Sensing Ion Channels1

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2023

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“…Making and characterization of Asic1, Asic2, Asic3 and Asic4 KO mice show differences in pain-sensing not only in comparison with wildtype but also between various KO lines. While ample data supports the role of ASIC in nociceptive response, the interpretation of results has been complicated by residual H + activated currents in DRG neurons of KO models 105,110 . Immunohistochemical studies show ample presence of ASIC1a, ASIC1b, ASIC2a and ASIC2 in the CNS of rodents 104,109 .…”

Section: Asic: Acid Sensing Ion Channelsmentioning

confidence: 99%

Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors

Ovsepian

Waxman

2023

Nat Rev Neurosci

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With sweeping advances in targeting and manipulations of genome and transcriptome, medical biotechnology offers unprecedented selectivity and control of a wide variety of biological processes, forging new opportunities for therapeutic interventions. This perspective summarizes the state-of-the-art gene therapies enabled by recent innovations with an emphasis on the expanding portfolio of molecular targets that govern the activity and functions of primary sensory neurons, which might be exploited for the effective treatment of chronic pain.

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