Acid-sensing ion channel 1: potential therapeutic target for tumor

Wang, Yinghong; Zhou, Hong; Sun, Yongkang; Huang, Yan

doi:10.1016/j.biopha.2022.113835

Cited by 7 publications

(4 citation statements)

References 73 publications

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“…ASIC is a type of cation channel located on the cell membrane. It opens in response to the binding of protons, resulting in the influx of extracellular cations and triggering various cellular activities [ 56 , 57 , 58 , 59 ]. Unlike other ASIC subunits, ASIC1 is unique in mediating the influx not only of Na + but also of extracellular Ca 2+ [ 58 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus

Chen,

Song,

Chen

et al. 2024

Biomedicines

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Oxeiptosis is a reactive oxygen species (ROS)-induced pathway of cell death. The involvement of circular RNAs (circRNAs) has been confirmed in the incidence and progression of intervertebral disc degeneration (IVDD). However, whether oxeiptosis occurs in IVDD and how circRNAs regulate oxeiptosis is still unclear. In this study, we discovered that oxeiptosis could be induced in nucleus pulposus cells (NPCs), and circFOXO3 was significantly upregulated after oxeiptosis induction. Transfection using circFOXO3 small interfering RNA (siRNA) significantly inhibited oxeiptosis in NPCs. Mechanistically, circFOXO3 upregulated acid-sensing ion channel subunit 1 (ASIC1) expression by functioning as a molecular sponge for miR-185-3p and miR-939-5p. Subsequent rescue experiments validated that circFOXO3 could regulate oxeiptosis in NPCs via the miR-185-3p/miR-939-5p-ASIC1 axis. Further research on ASIC1 functions indicated that this regulation was achieved by affecting the Calcium ion (Ca2+) influx mediated by ASIC1. A mouse IVDD model was established, and silencing circFOXO3 in vivo was found to inhibit IVDD development and the activation of the oxeiptosis-related pathway. Overall, circFOXO3 is one of the factors contributing to the progression of IVDD by mediating oxeiptosis.

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Section: Resultsmentioning

confidence: 99%

Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus

Chen,

Song,

Chen

et al. 2024

Biomedicines

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“…For instance, HCA1R is expressed not only in neoplastic tissue and ASIC1a is also involved in the development of different kinds of brain tumors ( 35 ).…”

Section: Lactic Acidosis In Structural Brain Abnormalitiesmentioning

confidence: 99%

“…It should be highlighted that the mechanisms described above may act to some extent in each of the discussed disorders (summarized in Figure 1). For instance, HCA1R is expressed not only in neoplastic tissue and ASIC1a is also involved in the development of different kinds of brain tumors (35).…”

Section: Lactic Acidosis In Structural Brain Abnormalitiesmentioning

confidence: 99%

High lactic acid levels in the brain contribute to the generation of focal slowing on the electroencephalogram

Chegodaev,

Pavlova

2024

Front. Neurol.

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Focal slowing on the EEG is often associated with structural pathology of the brain. Despite the clinical significance of focal slowing, the actual electrochemical mechanisms underlying this EEG phenomenon are still poorly understood. This paper briefly reviews the role of lactate in the pathogenesis of brain disorders that are primarily related to focal EEG slowing. An attempt is made to trace the hypothetical link between this EEG pattern and focal cerebral tissue lactacidosis.

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“…In addition to immunosuppressive cells and cytokines, the TME is characterized by several other abnormal physical factors, such as acidity (pH 6.0-6.9) [125] and hypoxia (O 2 < 2%) [126], which also limit the anti-tumor effect of immune cells [127][128][129]. However, new functions of CAR-T can be developed by taking advantage of these abnormal physical factors.…”

Section: Tme Responsementioning

confidence: 99%

Challenges and new technologies in adoptive cell therapy

Zhang,

Wan

2023

J Hematol Oncol

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Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and chimeric antigen receptor (CAR)-T cell therapies, many novel strategies for cancer treatment have been developed. Owing to its promising outcomes, CAR-T cell therapy has revolutionized the field of ACTs, particularly for hematologic malignancies. Despite these advances, CAR-T cell therapy still has limitations in both autologous and allogeneic settings, including practicality and toxicity issues. To overcome these challenges, researchers have focused on the application of CAR engineering technology to other types of immune cell engineering. Consequently, several new cell therapies based on CAR technology have been developed, including CAR-NK, CAR-macrophage, CAR-γδT, and CAR-NKT. In this review, we describe the development, advantages, and possible challenges of the aforementioned ACTs and discuss current strategies aimed at maximizing the therapeutic potential of ACTs. We also provide an overview of the various gene transduction strategies employed in immunotherapy given their importance in immune cell engineering. Furthermore, we discuss the possibility that strategies capable of creating a positive feedback immune circuit, as healthy immune systems do, could address the flaw of a single type of ACT, and thus serve as key players in future cancer immunotherapy.

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Acid-sensing ion channel 1: potential therapeutic target for tumor

Cited by 7 publications

References 73 publications

Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus

Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus

High lactic acid levels in the brain contribute to the generation of focal slowing on the electroencephalogram

Challenges and new technologies in adoptive cell therapy

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