Acid secretory response and electrolyte composition of gastric juice in Diabetic rats

Adewoye, Elsie O.; Olaleye, Samuel Babafemi; Ige, A. O.

doi:10.4314/ajbr.v10i2.50618

African Journal of Biomedical Research

2010

DOI: 10.4314/ajbr.v10i2.50618

|View full text |Cite

Acid secretory response and electrolyte composition of gastric juice in Diabetic rats

Elsie O. Adewoye¹,

Samuel Babafemi Olaleye²,

A. O. Ige³

Abstract: ABSTRACT

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…O. Ige et al Journal of Biosciences and Medicinesgastric acidity and electrolyte composiotion of gastric juice. Hence depletion of electrolytes in the extracellular fluid will likely affect the intracellular fluid concentration of the parietal and non-parietal cells that both contribute to the electrolyte composition of gastric juice[56]. While the exact effects of BPA exposure on the composition of gastric juice appear at present to be unknown, this study shows a reduction in bicarbonate (as discuss above previously) and chloride ion concentrations respectively, with no alterations in either sodium and potassium ion concentrations or the ratio of sodium to potassium (Na: K) in the BPA only treatment group.…”

mentioning

confidence: 99%

Genistein Mitigates the Gastro-Toxic Effects of Bisphenol A in Male Wistar Rats

Ige¹,

Adebayo²,

Adele³

et al. 2022

JBM

View full text Add to dashboard Cite

Exposure to Bisphenol A (BPA) worldwide is on the increase. Its toxicities in various tissues expressing estrogen receptors have been reported. However, limited information exists on its effects on the gastric tissue. This study therefore investigated the gastric effects of BPA exposure and the likely ameliorative potential of genistein, a phytoestrogen antioxidant, known to interact with estrogen receptors. Eighty-four male Wistar rats were randomly divided into 6 groups (n = 14) and orally treated for 28 days. Group I-IV received distilled water (0.2 ml), corn oil (3 ml/kg), BPA (50 mg/kg) and genistein (50 mg/kg) respectively. Group V was pre-treated daily with BPA one hour prior to genistein administration while Group VI was pre-treated daily with genistein one hour prior to BPA treatment. Thereafter, blood was collected into heparinized bottles for hematological analysis. Gastric juice was collected for pH and electrolytes determination. Gastric tissue was excised and analyzed for superoxide dismutase (SOD), reduced glutathione (GSH), malondialdehyde, nitric oxide (NO), mucin, parietal and mucous cell counts, and histology. The BPA only treatment group exhibited significant increases (p < 0.05) in white blood cell count, neutrophil-lymphocyte ratio, mucin concentration, NO, and malondialdehyde while gastric juice pH, bicarbonate, SOD, and GSH levels were reduced compared to control. The gastric mucosa also showed pathologies consistent with inflammation. Genistein pre-and post-treatment in BPA exposed rats significantly (p < 0.05) ameliorated these effects of BPA. However, some signs of gastric inflammation were still evident in the mucosal samples. Bisphenol A induces gastro-toxicity by increasing gastric acidity, reducing gastric juice bicarbonate level and disrupting prooxidant/antioxidant balance. Genistein pre-and post-treatment ameliorated these gastro-toxic effects of Bisphenol A via gastroprotective, antioxidant and anti-inflammatory mechanisms.

show abstract

mentioning

confidence: 99%

Genistein Mitigates the Gastro-Toxic Effects of Bisphenol A in Male Wistar Rats

Ige¹,

Adebayo²,

Adele³

et al. 2022

JBM

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

334 Leonard St

Brooklyn, NY 11211

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Acid secretory response and electrolyte composition of gastric juice in Diabetic rats

Abstract: ABSTRACT

Cited by 1 publication

References 14 publications

Genistein Mitigates the Gastro-Toxic Effects of Bisphenol A in Male Wistar Rats

Genistein Mitigates the Gastro-Toxic Effects of Bisphenol A in Male Wistar Rats

Contact Info

Product

Resources

About