Acid Secretion and Its Relationship to Esophageal Reflux Symptom in Patients with Subtotal Gastrectomy

Oh, Hyoung‐Chul; Choi, Myung-Gyu; Park, Jae Myung; Song, Kyo Young; Yoo, Han Mo

doi:10.1007/s10620-018-4923-9

Cited by 8 publications

(4 citation statements)

References 32 publications

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“…Most postoperative patients have varying degrees of acid reflux [26]. The causes of this phenomenon may be as follows: (1) the absence of a lower esophageal sphincter, (2) peristaltic dysfunction and diminished digestive function of the remnant stomach, and (3) altered esophageal and gastric remnant physiological functions due to vagal denervation during surgery [27]. On the 24-h pH monitoring of the remnant esophagus at 1 week after surgery, there were no significant differences in reflux trends between the two groups.…”

Section: Discussionmentioning

confidence: 99%

Comparison of outcomes of pedicled jejunal and colonic conduit for esophageal reconstruction

et al. 2020

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Background At present, the gastric tube is the first choice for esophageal reconstruction after esophagectomy for various benign and malignant diseases. However, when the stomach is not available, a pedicled jejunum or colon is used to reconstruct the esophagus. The present study aimed to compare the postoperative outcomes and quality of life of patients receiving jejunal and colonic conduits. Methods In the present retrospective study, the clinical data of 71 patients with esophageal carcinoma, who received jejunal reconstruction (jejunum group, n = 34) and colonic reconstruction (colon group, n = 37) from 2005 to 2015, were compared. Results Compared with the colon group, the jejunum group had a lower incidence of postoperative anastomotic leakage, lesser duration of postoperative drainage, and faster recovery. Furthermore, the scores were better in the jejunum group than in the colon group, in terms of short-term overall quality of life, physical function and social relationships. Moreover, the jejunal group had a significantly lower frequency of pH < 4 simultaneous reflux time > 5 min (N45) and the longest reflux time (LT) at 24 weeks after surgery. Conclusion In esophageal cancer, when gastric tube construction is not feasible, a pedicled jejunum may be preferred over a colonic conduit due to lower incidence of acid reflux, anastomotic leakage and higher postoperative short-term quality of life, and rapid postoperative recovery.

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Section: Discussionmentioning

confidence: 99%

Comparison of outcomes of pedicled jejunal and colonic conduit for esophageal reconstruction

et al. 2020

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“…At present, thoracoscopy combined with laparoscopy to free the thoracic esophagus and abdominal proximal gastric body, along with the final external reconstruction with tubular stomach tissue, are relatively mature surgical methods (37). However, after resection of the proximal gastric body, the anti-reflux mechanism is lost, and digestive juices of the patient can easily migrate upward when the patient is lying flat (38). Digestive juices are highly acidic, and the newly formed granular tissue at the esophagogastric anastomosis is more vulnerable to corrosion (39).…”

Section: Discussionmentioning

confidence: 99%

A new technology for reducing anastomotic fistula in the neck after esophageal cancer surgery

Song

Zhang

et al. 2019

J. Thorac. Dis

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“…Secondly, the administration of broad-spectrum antibiotics after surgery may inhibit the function of normal flora, leading to the proliferation of drug-resistant harmful microflora, with the occurrence of symptomatic gastrointestinal episodes, such as the excessive passage of gas, foul smell of flatulence, belching, heartburn, abdominal noises, abdominal bloating, and abdominal pain [23]. Thirdly, surgical trauma may alter the permeability of the intestinal mucosa, which not only causes local inflammation but also leads to the disorder of gastrointestinal flora, which in turn aggravates inflammatory respons [24]. Moreover, surgery also affects the number of intestinal microflora, as reported, the relative abundance of intestinal Bifidobacterium and Lactobacillus acidophilus decreased, while the Escherichia coli and Streptococcus usually increased after colon resection in colorectal cancer patient [25].…”

Section: Interaction Between Gastrointestinal Tumors and Microorganis...mentioning

confidence: 99%

Intestinal Microbiomes In Gastrointestinal Cancer

Lin¹,

Zhao²

2023

HSET

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The intestinal flora, a crucial system of microorganisms in the human body, is crucial to the immune system, metabolism, and inflammatory response of the body. The intestinal flora is one of them, and as a crucial element of the gastrointestinal microecology, it has a significant impact on the development and spread of gastrointestinal cancer as well as its management. The study of intestinal flora has become more in-depth recently as a result of the quick advancement of high-throughput sequencing technology, and the role of intestinal flora in the development and prognosis of gastrointestinal cancer is becoming increasingly obvious. In this article, the key topics covered include the links between Helicobacter pylori and gastric cancer, as well as the relationship between Fusobacterium and colon cancer, and discusses the mechanism by which intestinal microbes affect the treatment of gastrointestinal cancer. The link between gut microbiota and gastrointestinal cancer was further clarified, and the regulation of gut microbiota was proposed as a new management method for the clinical gastrointestinal cancer treatment.

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Acid Secretion and Its Relationship to Esophageal Reflux Symptom in Patients with Subtotal Gastrectomy

Abstract: Esophageal reflux symptom is common in patients after subtotal gastrectomy, possibly because of anti-reflux-barrier impairment and preservation of acid secretory capacity following surgery. Optimal acid suppression may be helpful in managing postoperative esophageal reflux symptom.

Cited by 8 publications

References 32 publications

Comparison of outcomes of pedicled jejunal and colonic conduit for esophageal reconstruction

Comparison of outcomes of pedicled jejunal and colonic conduit for esophageal reconstruction

A new technology for reducing anastomotic fistula in the neck after esophageal cancer surgery

Intestinal Microbiomes In Gastrointestinal Cancer

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