Acid reflux and hoarseness

Jones, N S; Lannigan, Francis J.; McCullagh, Majella; Anggiansah, Angela; Owen, W J; Harris, Tom

doi:10.1016/s0892-1997(05)80053-0

Cited by 8 publications

(7 citation statements)

References 22 publications

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“…Clinically, the use of anti-reflux medication has been shown to provide some improvement (78,79); however, many of the existing studies predate PPI usage and are uncontrolled. Fraser et al (79) found that there was a good correlation between severity of acid reflux when monitored and improvement of symptoms with therapy (using Spearman's rank correlation, p 0.01).…”

Section: Therapeutic Resultsmentioning

confidence: 99%

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A review of the atypical manifestations of gastroesophageal reflux disease

Chandra

Moazzez

Bartlett

et al. 2004

International Journal of Clinical Practice

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Manifestations of atypical gastroesophageal reflux disease (GORD) are varied, and the presentation of atypical symptoms may occur in the absence of typical symptoms. The most sensitive and specific investigation for GORD is pH monitoring, and its application in atypical disease is utilized throughout this paper as a basis for correlating disease and pathogenesis. The less well-known areas of laryngeal manifestations, particularly chronic hoarseness and globus, are discussed in addition to recent work on orodental manifestations. Well-known areas of cardiac and respiratory manifestations, which include chronic cough and asthma, are also reviewed. Evidence from clinical trials indicates that aggressive anti-reflux therapy in patients with atypical symptoms can be effective. Where appropriate, medical therapy may involve long-term proton pump inhibitor, although further research outlining the roles of other therapies such as surgery is awaited.

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Section: Therapeutic Resultsmentioning

confidence: 99%

“…Clinically, the use of anti‐reflux medication has been shown to provide some improvement (78,79); however, many of the existing studies predate PPI usage and are uncontrolled. Fraser et al .…”

Section: Laryngeal Manifestationsmentioning

confidence: 99%

A review of the atypical manifestations of gastroesophageal reflux disease

Chandra

Moazzez

Bartlett

et al. 2004

International Journal of Clinical Practice

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“…During the last decade it has often been reported that dysphonia may be concomitant with oesophageal acid reflux [39]. There is still controversy as to whether the dysphonia reported in some patients with acid reflux arises as a direct result of mucosal irritation from laryngeal overspill on to the posterior third of the larynx or from (possibly protec tive) reflex hyperkinetic activity of the vocal tract.…”

Section: Oesophageal Acid Reflux and Dysphoniamentioning

confidence: 99%

“…There is still controversy as to whether the dysphonia reported in some patients with acid reflux arises as a direct result of mucosal irritation from laryngeal overspill on to the posterior third of the larynx or from (possibly protec tive) reflex hyperkinetic activity of the vocal tract. In one trial [39], over 50% of patients with hoarseness who reported symptoms of reflux more than once per week proven to have significant reflux by ambulatory pH ma nometry and fibre endoscopy. Treatment with H?…”

Section: Oesophageal Acid Reflux and Dysphoniamentioning

confidence: 99%

The Pharmacological Treatment of Voice Disorders

Harris

1992

Folia Phoniatr Logop

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The increasing diversity of purpose-built, synthetic and biogenetically engineered pharmaceuticals has led to a revival of interest in the pharmacological possibilities for the treatment of voice disorders. Where dysphonias arise as a part of a pathophysiological process, the pharmacological treatment of either the pathology or its associated symptoms may improve dysphonie voicing patterns. The treatment of symptoms such as cough and vocal fatigue are discussed together with treatment of allergic and other causes of inflammation or stiffening of the vocal tract. The pharmacological treatment of dysphonia due to defective neuromuscular control in dyskinetic and dystonic conditions is also discussed. Dysphonie voicing patterns are commonly multifactorial, and the author wishes to highlight problems encountered when attempting to adjust the performance of the vocal tract: imprecise targeting of the pathophysiological problems either by the physician or by the drug employed, and the systemic and attendant side-effects of drugs which may be thought to be appropriate.

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“…To our knowledge, there has been only one report of prolonged upper oesophageal sphincter pressure monitoring, performed in inpatient, non‐ambulant subjects 8 . There is continued interest in oesophago‐pharyngeal reflux, due to its possible association with a wide variety of laryngeal diseases 9 and disorders of the lower respiratory tract 10 . Nonetheless, the literature reports normal reference ranges for healthy subjects in only 12–13 adults 11,12 and six paediatric subjects 13 .…”

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confidence: 99%

Pattern of ambulatory pharyngo-oesophageal motility and pH-metry in healthy volunteers1

et al. 2001

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Oesophago-pharyngeal reflux is widely accepted as an aetiological factor in many laryngeal and lower respiratory tract diseases. This study aims to establish normal reference ranges for pharyngo-oesophageal pH and pressure. Twenty-five asymptomatic healthy volunteers underwent ambulatory pharyngo-oesophageal pressure and pH-metry. Acid exposure times were very low. Only one subject showed any evidence of oesophago-pharyngeal reflux during recumbency. Two distinct upper oesophageal sphincter pressure patterns were observed during recumbency-one with episodic dry swallows and moderate tonic pressures, the other with almost complete manometric quiescence. Negative results, i.e. the exclusion of abnormal cervical reflux, appear to be more achievable than quantifiable positive results, but this is not absolutely clear from our results. Categorisation of an individual as having abnormal upper pH-metry requires use of a synchronous pharyngeal probe. pH-metry is likely to be of value in establishing the role of reflux in relation to laryngeal or respiratory disease.

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Acid reflux and hoarseness

Cited by 8 publications

References 22 publications

A review of the atypical manifestations of gastroesophageal reflux disease

A review of the atypical manifestations of gastroesophageal reflux disease

The Pharmacological Treatment of Voice Disorders

Pattern of ambulatory pharyngo-oesophageal motility and pH-metry in healthy volunteers1

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