Acid/reduction dual-sensitive amphiphilic graft polyurethane with folic acid and detachable poly(ethylene glycol) as anticancer drug delivery carrier

Tao, Wangwang; Wang, Jun; Zhou, Yu; Li, Zhaoxia; Chen, Hongxiang; Zhao, Zuyi; Yan, Hao; Liao, Xing–Hua

doi:10.1016/j.colsurfb.2022.113084

Cited by 5 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, they measured the cytotoxicity using CCK-8 assay on HGC-27 cells as proliferating cells, and the results indicated that the cell viability decreased at pH 6.5. The outcomes of cell experimentation further proved that, under physiologically normal settings, micelles were less cytotoxic than pure DOX and exhibited an acid/reduction dual-sensitivity feature . The results showed that the mPEG detachment increased with the pH decrease.…”

Section: Biomedical Applicationsmentioning

confidence: 82%

“…The outcomes of cell experimentation further proved that, under physiologically normal settings, micelles were less cytotoxic than pure DOX and exhibited an acid/reduction dualsensitivity feature. 94 The results showed that the mPEG detachment increased with the pH decrease.…”

Section: Biomedical Applicationsmentioning

confidence: 96%

“…93 In a recent article, Tao et al designed a folic acid loaded acid/reduction dual-responsive polyurethane with detachable PEG self-assembled in an aqueous solution to produce nanomicelles with a particle size of around 174 nm and a surface charge of 6.06 mV, which provided highly stable micelles. 94 Moreover, TEM images showed that the micelles were spherical under GSH concentrations from 0 to 10 μM. On the other hand, they measured the cytotoxicity using CCK-8 assay on HGC-27 cells as proliferating cells, and the results indicated that the cell viability decreased at pH 6.5.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

See 2 more Smart Citations

Polyurethane Nanoparticles as Versatile Tools in Nanomedicine: A Review

Saha,

Trivedi,

Rengan

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

The rapidly advancing field of nanomedicine has witnessed the emergence of polyurethane nanoparticles (PUNPs) as exceptionally versatile tools with transformative potential. This comprehensive review dives into the various roles that PUNPs play in the realm of nanomedicine, positioning them as pivotal components in therapeutic, diagnostic, and theranostic applications. With a focus on their unique characteristics, these nanoparticles offer a platform for precision at the nanoscale, a critical attribute in the intricate landscape of medical interventions. This review precisely navigates through the biobased synthesis method and the recent applications (2019−2023) of PUNPs in the therapeutic, diagnostic, and theranostic fields. Furthermore, it explores innovative approaches in surface functionalization, elucidating how tailored modifications can optimize their interaction with biological entities. Beyond the conventional realm, PUNPs emerge as carriers of therapeutic cargo and strategic players in diagnostics and theranostics, showcasing their multifaceted utility. In conclusion, this review navigates beyond generalized statements, offering a tailored exploration into the specific attributes that make polyurethane nanoparticles indispensable in advancing the frontiers of nanomedicine. Through a meticulous examination of their synthesis, functionalization, and applications, this review aims to contribute a different understanding of PUNPs' versatile roles in drug delivery systems, imaging, and theranostics.

show abstract

Section: Biomedical Applicationsmentioning

confidence: 82%

Section: Biomedical Applicationsmentioning

confidence: 96%

Section: Biomedical Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Polyurethane Nanoparticles as Versatile Tools in Nanomedicine: A Review

Saha,

Trivedi,

Rengan

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

“…Additionally, polyurethane drug delivery systems (PU DDSs) can be tailored to respond to specific stimuli like pH, temperature, or enzymatic activity, triggering drug release solely upon encountering the desired conditions. Leveraging polyurethane in nanoparticle form facilitates the creation of carriers boasting high surface areas, enhancing drug loading capacity and enabling precise delivery to specific cells or tissues ( Tao et al, 2023 ). To meet these requirements, Song and colleagues devised an innovative polyurethane nanomicelle with targeting capabilities and tumor-degradable features for the versatile delivery of anticancer drugs.…”

Section: Targeted Polyurethane Drug Deliverymentioning

confidence: 99%

The state-of-art polyurethane nanoparticles for drug delivery applications

Song,

Muhammad,

Dang

et al. 2024

Front. Chem.

View full text Add to dashboard Cite

Nowadays, polyurethanes (PUs) stand out as a promising option for drug delivery owing to their versatile properties. PUs have garnered significant attention in the biomedical sector and are extensively employed in diverse forms, including bulk devices, coatings, particles, and micelles. PUs are crucial in delivering various therapeutic agents such as antibiotics, anti-cancer medications, dermal treatments, and intravaginal rings. Effective drug release management is essential to ensure the intended therapeutic impact of PUs. Commercially available PU-based drug delivery products exemplify the adaptability of PUs in drug delivery, enabling researchers to tailor the polymer properties for specific drug release patterns. This review primarily focuses on the preparation of PU nanoparticles and their physiochemical properties for drug delivery applications, emphasizing how the formation of PUs affects the efficiency of drug delivery systems. Additionally, cutting-edge applications in drug delivery using PU nanoparticle systems, micelles, targeted, activatable, and fluorescence imaging-guided drug delivery applications are explored. Finally, the role of artificial intelligence and machine learning in drug design and delivery is discussed. The review concludes by addressing the challenges and providing perspectives on the future of PUs in drug delivery, aiming to inspire the design of more innovative solutions in this field.

show abstract

“…Furthermore, there is a difference in tumor extracellular and intracellular pH values (pH ex = 6.5–7.2 and pH in = 4.5–6.5). The pH‐sensitive linkages, such as hydrazine, 28 benzoic‐imine, 29 thioketal, 30 acetal, 31 and orthoester 32 have been used for conjugation of PEG to carriers. To improve cellular uptake, the shedding of shell should be able to restore the positive surface charge of the nanocarriers at the target site.…”

Section: Introductionmentioning

confidence: 99%

Shell‐sheddable and charge switchable magnetic nanoparticle as pH‐sensitive nanocarrier for targeted drug delivery applications

Aram,

Sadeghi‐Abandansari,

Radmanesh

et al. 2024

Polymers for Advanced Techs

View full text Add to dashboard Cite

A pH‐sensitive shell‐sheddable magnetic nanocarrier was prepared based on Fe3O4@SiO2 nanoparticles coated with polyethyleneimine (PEI) and polyethyleneglycol (PEG). The PEI was coated on Fe3O4@SiO2 nanoparticles through an electrostatic attraction and the PEG chains were connected to the PEI via pH‐sensitive benzoic‐imine bonds. The synthesized products and final nanocarrier were characterized with FT‐IR, 1H NMR, dynamic light scattering (DLS), zeta‐potential, TEM, and vibrating‐sample magnetometer (VSM). The PEI, as a middle layer, was used to load the curcumin (an anticancer drug) via van der Waals interactions and the shedding of PEG as a hydrophilic corona at the tumor pH (acidic) could induce the release of the drug. The curcumin loading content was found to be ~15% and curcumin‐loaded magnetic nanoparticles (C‐LMNs) showed more triggered release at the tumor pH (5.6) than physiological pH (7.4). In comparison to pure magnetic nanoparticles (MNs), the C‐LMNs showed more cytotoxicity to human prostate cancer cell (PC‐3) and also resulted in an increased rate of late apoptotic/necrotic PC‐3 cells, assessed by flow cytometry analysis. In conclusion, the C‐LMN as pH‐ and magnetic responsive nanocarrier showed good potential for targeted curcumin delivery in therapy of prostate cancer.

show abstract

Acid/reduction dual-sensitive amphiphilic graft polyurethane with folic acid and detachable poly(ethylene glycol) as anticancer drug delivery carrier

Cited by 5 publications

References 22 publications

Polyurethane Nanoparticles as Versatile Tools in Nanomedicine: A Review

Polyurethane Nanoparticles as Versatile Tools in Nanomedicine: A Review

The state-of-art polyurethane nanoparticles for drug delivery applications

Shell‐sheddable and charge switchable magnetic nanoparticle as pH‐sensitive nanocarrier for targeted drug delivery applications

Contact Info

Product

Resources

About